1.Applied Value of Electroencephalogram in Assessment of Mild Psychiatry Impairment
jun Jian WANG ; zhe Hao LI ; yu Hui FAN ; Chen CHEN ; yu Sheng ZHANG ; Chao LIU ; jie Jun WANG ; xiong Wei CAI ; ting Qin ZAHNG
Journal of Forensic Medicine 2017;33(5):501-505
Objective To explore the applied value of electroencephalogram (EEG) in assessment of psychiatric impairment among patients with mental disorders due to traumatic brain injury.Methods According to the ICD-10,a total of 271 subjects were enrolled and assessed with the criterion of mental disorders due to traumatic brain injury.Activity of Daily Living Scale (ADL),Functional Activities Questionnaire (FAQ) and Social Disability Screening Schedule (SDSS) were used to evaluate the severity of patients.All the participants were tested by Wechsler Adult Intelligence Scale (WAIS) and examined by EEG.Results Totally 215 patients accomplished the study.The results of Glasgow Coma Scale (GCS),the severity of craniocerebral injury and the scores of FAQ,SDSS and ADL showed significant difference among the patients with different severity of EEG (P<0.05).The grades of psychiatric impairment showed significant difference among the patients with different abnormal EEG (P<0.05).Conclusion EEG can reflect the severity of craniocerebral injury,assist evaluate the social function and activity of daily living of patients with mental disorders due to traumatic brain injury,and distinguish the mild psychiatric impairment grades,which suggest that EEG has a certain reference value in the assessment of psychiatric impairment.
2.Working Memory of Patients with Mild Cognitive Impairment due to Brain Trauma Based on fNIRS.
Fan CHANG ; Hao Zhe LI ; Sheng Yu ZHANG ; Chen CHEN ; Chao LIU ; Hui Yu FAN ; Yan XING ; Qin Ting ZAHNG ; Wei Xiong CAI
Journal of Forensic Medicine 2020;36(1):52-60
Objective To discuss the activation characteristics of the prefrontal cortex of people with mild cognitive impairment (MCI) due to brain trauma during working memory tasks. Methods The psychological experiment design software E-prime was used and N-back paradigm was adopted as working memory task. Functional near-infrared spectroscopy (fNIRS) was used to detect changes in cortical oxygenated hemoglobin concentrations of 22 channels within the prefrontal lobe of 24 people with MCI due to brain trauma (study group) and 27 healthy volunteers (control group) with matching gender and age. Behavioral data, such as the number of keystroke errors and reaction time, were recorded simultaneously. Independent samples t test and non-parametric test were used to compare the mean value of oxygenated hemoglobin concentration change, the number of key errors and the mean value of reaction time of the two groups in each task. Results (1) The differences in the number of errors and reaction time between the two groups in 1-back and 2-back tasks had statistical significance (P<0.05).The main effects of task load and group were both significant (task F=14.11, P=0.001 1; group F=10.39, P=0.001 5). (2) During the 1-back task, the differences in oxygenated hemoglobin concentration changes of the 22 channels between the two groups had no statistical significance (P>0.05). During the 2-back task, the differences in oxygenated hemoglobin concentration changes of the two groups in channel 2, 3, 7, 9, 10, 11, 14, 15, 18, 19, 21 and 22 had statistical significance (P<0.05). (3) In the 1-back task, the left frontal pole and dorsolateral prefrontal area in both groups were activated. In the 2-back task, the activation areas of the control group were the left frontal pole area and the left dorsolateral prefrontal area, while that of the study group almost covered most of the left and right frontal pole areas, which were scattered and the right area was activated, too. Conclusion Patients with MCI due to brain trauma have obvious working memory impairment, and during the 2-back working memory task, the activation of the prefrontal lobe decreased, but the activation range was wider.
Brain Injuries, Traumatic/complications*
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Cognitive Dysfunction/etiology*
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Humans
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Memory, Short-Term
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Prefrontal Cortex
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Spectroscopy, Near-Infrared