The concept of white matter dementia was first introduced by Filley in 1988.It was found following behavioral neurologica researches that patients with this type of dementia manifested the dysfunctions of sustained attention,memory retrievial,frontal lobe and visualspatial function.They also had psychiatric manifestations but language and extrapyramidal function remained normal.10 diseases of white matter disorders are listed for understanding the clinical characteristics of this type of dementia.

Objective To evaluate the clinical efficacy of intensive needling stimulation at external Laogong (EX-UE 8) in treating post-stroke hand hypermyotonia.Method Sixty patients with post-stroke hand hypermyotonia were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by ordinary acupuncture plus strong stimulation at external Laogong (EX-UE 8), while the control group was by ordinary acupuncture. After 8-week treatment, the modified Ashworth Scale (MAS) was used to assess the muscular tension of the affected limbs, Fugl-Meyer Assessment (FMA) was for assessing motor function of the affected hand, and Activities of Daily Living (ADL) was used to evaluate the activities of daily living before and after the intervention.Result The MAS, FMA, and ADL scores were significantly changed after the intervention in both groups (P<0.05). The MAS, FMA, and ADL scores of the treatment group were significantly different from that of the control group (P<0.05).Conclusion Acupuncture at external Laogong (EX-UE 8) with intensive stimulation is an effective approach in treating post-stroke hand hypermyotonia.

The Balanced Scorecard,as a new strategic management tool,has been widely used in the performance evaluation of Chinese enterprise.This review discussed the application and potential problems of the Balanced Scorecard in the research performance management of the research universities.

Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β ( IL-1β) , which are critical for inflammation and control of pathogen infection. Inflammasomes are involved in and regulate diversified diseases due to its capability to sense multiple danger signals. In this review, we present the activation and regulation mechanisms for different inflammasomes and discuss how genetic mutations in inflammasome-related genes or abnormal activity of in-flammasomes lead to diseases. Insights into the role of inflammasome in various human diseases will provide sound theoretical basis and effective treatment strategy for these disease.

Objective To investigate the therapeutic effect of flupentixol and melitracen tablets for irritable bowel syndrome (IBS).Methods Relevant concerned with the therapeutic effect of Flupentixol and melitracen tablets and routine medicine were reviewed by China national knowledge infrastructure.All reviewed literatures were accessed by Jadad quality scale.Statistic data was analysed by RevMan5.0 and Stata.Results Twelve articles of randomized controlled trial were collected.Among these study,there were 1384 patients,which divided into treatment group (n =704) and control group (n =680).The results of heterogeneity showed that x2 =25.48,P =0.008,I2 =57％.Therefore the random effects model was selected.The combined relative risk is 1.39 and the 95％ CI was 1.27-1.53.Conclusion Compared with traditional treatment,flupentixol and melitracen tablets can obviously improve the therapeutic effect of IBS.

Objective To investigate the reason of fracture internal fixation of locking plates and conventional plate in the treatment of femoral fractures.Methods A total of 198 patients with femoral fracture taken plate fixation were selected as our subjects.Of which,the locking plate were used in 87 cases served as control group and 111 cases had traditional plate fixation served as study group.Fracture fixation rate in patients were follow-up and the reasons for broken were analyzed.Results Fracture fixation occurred 5 cases (4.5％,5/111) in the locking plate,and 3 cases (3.4％,3/87) in traditional plate,and the difference was not significant (x2 =0.053,P =0.987).Fracture reason included plate fracture (4 cases),fracture of screws (2 cases) and plate fracture complicated with breakage of screw (2 cases).Iatrogenic factors lead fracture fixation was 30.0％ (3/10),significantly higher in patients with rehabilitation exercises errors (6.9％,2/29; x2 =3.851 ; P =0.046).Both iatrogenic factors and rehabilitation exercises errors caused fracture fixation rate was 100％.Conclusion Iatrogenic factors combined rehabilitation exercises error was the main reasons in fracture fixation.We should properly choose fixation methods and correctly guide the postoperative functional exercise for patients.

In order to observe the pattern of energy expenditure in trauma patients,the REE, substrate oxygenization and nitrogen balance were measured in1 8severely injured patients. REE in posttrauma day1 was1 882? 2 45 kcal/d,1 .1 9of HBBEE,reduced gradually to normal range on posttrauma day 1 0 .REE in single trauma patients decreased more rapidly than that in multiple trauma patients.REE in patients with APACHE ≥ 1 2 was higher than that in patients with APACHE

Objective To understand the mental health, especially the anxiety of patients suffering from acute trauma in order to adapt the patients to the situation of acute trauma and cope with acute trauma better in physiological and psychological health. Methods Questionnaire designed by means of Symptom Checklist 90(SCL 90) and Self rating Anxiety Scale(SAS) was used to survey the stress response of the patients to anxiety induced by acute trauma. Results The parameters in SCL 90 of acute trauma patients were significantly higher than those of the normal control( P

G protein-coupleed receptor kinases (GRKs)not only regulates phosphorylation of G protein-coupled receptor which mediates receptor desensitization and initiates profound impairment of receptor signaling,but also regulates G protein and cytoskeleton. Meanwhile GRKs are regulated by protein kinase A, protein kinase C,actin and calcium/calmodulin. Surface of cell has many kinds of G protein-coupled receptor such as PAF receptor, histamine receptor, thrombine receptor which initiates signal effect of cell injury induced by inflammatory mediator. So GRKs have a certain regulatory role in the process of inflammation-induced cell injury through phosphorates G protein-coupled receptor.