Objective To investigate the effects of Xiaoke Wan on serum adiponectin levels in patients with type 2 diabetes metlitus. Methods A total of 60 2TDM patients with deficiency of both qi and yin syndrome were recruited into a control group and a treatment group randomly, 30 cases in each group. The treatment group was treated with Xiaoke Wan, and the control group was treated with glibenclamide. After 32 weeks, the changes of FPG, 2hPG, HbAIc, FINS, C-P, APN, HBCI,IRI and improvement of symptoms were compared between the two groups. Results Compared with glibenclamide, Xiaoke Wan can significantly improve the patients' symptoms, reduce the level of IRI (t=-1.590, P=-0.036), and increase serum APN (t=1.918, P=0.002). Conclusion Xiaoke Wan can significantly improve symptoms, reduce fasting blood glucose and 2 hour postprandial blood glucose, recover the secretion of adipouectin, decrease insulin resistance in 2TDM patients with deficiency of both qi and yin.

Alternating hemiplegia of childhood(AHC) is a hereditary disease characterized by hemiplegia spells,abnormal eye movements,dystonia and cognitive impairment.There are three phases of the disease.Each phase has its unique clinical symptoms:phase 1-abnormal eye movements and dystonia;phase 2-hemiplegia spells; phase 3-permanent cognitive impairment.The severity of cognitive impairment depends on the time of onset of hemiplegia spells:the earlier the onset is,the worse outcome will be.No effective treatment has been established.Thetreatments currently include:avoiding predisposing factors and taking drugs such as flunarizine to prevent hemiplegia attacks,in the inter-ictal stage;and sedation during hemiplegia attacks.According to the latest research,AHC is caused by the de novo mutation of gene ATP1A3.

?AlM:To evaluate the effect and safety of 1. 8mm coaxial microincision phacoemulsification - trabeculetomy with ultra-thin intraocular lens ( lOL ) implants for treating glaucoma complicated with cataract, and to compare with the traditional 3. 0mm small phacoemulsification-trabeculetomy with foldable lOL implantion.
?METHODS: ln this prospective study, 36 patients ( 36 eyes) with glaucoma and cataract in lnner Mongolia Autonomous Regian People’s Hospital were collected and randomly divided into 2 groups. For the small incision group: 18 cases ( 18 eyes ) underwent 3. 0mm coaxial incision phacoemulsification-trabeculetomy with foldable lOL implantion; ln th microincision group: 18 cases ( 18 eyes ) underwent 1. 8mm microincision phacoemulsification-trabeculetomy with ultra-thin lOL implantion. The two groups were recorded for 1wk, 1 and 3mo of visual acuity, corneal endothelial cell density, surgically induced astigmatism, intraocular pressure ( lOP ) , filtering bleb and complications. Pearson’s Chi-square test ande t-test were used to determine differences between the two groups.
?RESULTS:At 1wk postoperatively, visual acuity in the microincision group was better than that of small incision group, the difference was statistically significant ( P<0. 05). At 1 and 3mo, the difference in corrected visual acuity between the 2 groups had no significant difference (P>0. 05). At 1wk, 1 and 3mo, there was a significant different between the 2 groups in surgically induced astigmetism (P<0. 05). At 1wk postoperatively, there was a significant difference in corneal endothelial cells density between 2 groups (P<0. 05). But there were no significant difference at 1 and 3mo ( P > 0. 05 ). lOP reduced after surgy ( microincision group: 15. 26 ±3. 12mmHg, small incision group: 14. 57±2. 86mmHg), there was no significant difference between the 2 groups (P>0.05). There was no significant different between the 2 groups in blebs (P>0. 05). Neither iris injury, posterior capsule rupture nor anterior chamber bleeding complications was found in any groups.
?CONCLUSlON: TBy compared with traditional 3. 0mm coaxial small incision phacoemulsification -trabeculectomy with foldable lOL implantion, 1. 8mm microincision phacoemulsification-trabeculectomy withe ultra- thin lOL implantion can effectively reduce the astigmatism operation. This operation is safe, effective, convenient surgy for treating cataract and glaucoma.

Carcinoma, Squamous Cell ; metabolism ; pathology ; Esophageal Neoplasms ; metabolism ; pathology ; Humans ; Mitogen-Activated Protein Kinase Kinases ; metabolism ; NF-kappa B ; metabolism ; Prognosis ; STAT Transcription Factors ; metabolism ; Signal Transduction ; Transforming Growth Factor beta ; metabolism ; Wnt Proteins ; metabolism

Objective To explore the clinical characteristics and outcome of neonates transferred by different ways. Method A total of 1 027 neonates transferred to neonatal intensive care unit(NICU)of our hospital from July 2009 to July 2010 were analyzed prospectively. They were divided into three groups: twoway transport(TWT),hospital-aided one-way transport(HAT)and self-help one-way transport(SHT).The conditions at admission and discharge and pre-hospital care of the neonates were compared between the groups. The data were statistically analyzed with square tests, variance analysis and Mann Whitney U test. Results The median ages of TWT,HAT, and SHT groups at admission were 0.46 d,0.33 d and 5 d respectively. The TWT and HAT neonates had smaller gestational age and birth weight than SHT ones, had more severe conditions and cost more,and the differences were significant(P<0.05).Significant differences existed in all emergency treatment except in warming measures(x2=96.855～103.863,P<0.05).The cure percentage at discharge was the highest in SHT group,and differences in treatment results of three groups were significant(Z=-1.987 to-5.347,P<0.05).Conclusions The TWT and HAT neonates have smaller gestational age,ages at admission and birth weight than SHT ones,have more severe conditions,cost more and lower cure percentage at discharge than SHT ones.

This paper analyzes that information techniques have agreat dmpact on the construction of literature resource.It also presents problems involved in the current information resources development in a special library.Based on the above analysis,the authors put some suggestions in order to improve the quality of the literature resource construction.

ObjectiveTo investigate the expression of a disintegrin-like and metalloproteinase 8 ( ADAM8 ) in breast cancer and in normal breast tissues and its negative regulation role in tumorigenesis and progress of breast cancer.MethodsThe expression of ADAM8 in breast cancer and normal breast tissues was detected by immunohistochemistry (IHC),qRT-PCR,and Western blot.The relation between ADAM8 expression and the clinicopathological parameters of breast cancer patients was analyzed.ResultsADAM8 was expressed in breast cancer and normal breast tissues.The expression of ADAM8 mRNA and protein was significantly lower in breast cancer than in normal breast tissues (qRT-PCR:P =0.015,IHC:P =0.044,Western blot:P =0.000).The expression rate of ADAM8 was related to lymph node metastasis,tumor stage and tumor size,although the difference had no statistical significance.IHC results showed that ADAM8 expression level was lower in stage Ⅲ + Ⅳthan in stage Ⅰ + Ⅱ ( P =0.574 ).qRT-PCR showed ADAM8 mRNA expression was lower in stage Ⅱb + Ⅲ than in stage Ⅰ + Ⅱ a ( P =0.247).ADAM8 expression was lower in the breast cancer tissues with lymph node metastasis than in those without lymph node metastasis (P =0.560 by IHC and P =0.592 by qRT-PCR).ADAM8 expression was lower in tumors whose size ＞ 2 cm than in tumors whose size ≤ 2 cm,however,the difference had no statistical significance ( P ＞ 0.05 ).ConclusionsADAM8 is significantly lower-expressed in breast cancer than in normal breast tissues,which is associated with clinical stages and lymph node metastasis.The reduced expression of ADAM8 may play a role in the pathogenesis and progress of breast cancer.

There are some risk points in the management process of enterprises-funded research project,such as verification of the qualification of the client,the audit of the contract,the report of the research results,and the protection of intellectual property.This paper puts forward the management mode of the research project,which is based on the contract management,strengthen the management of enterprises-funded research project from every processes the contract develop,sign,fulfill and delivery.

Objective To determine the related facuors of side branch occlusion after stent implantion in the main branch of biburcation lesions.Methods We retrospectively analyzed 121 bifurcation lesions in 92 patients who accepted percutaneous coronary interventional therapy in our hospital from 2005 September to 2006 January.We employed quantitive coronary angiography analysis after stenting in the main branch and then evaluated the factors related to side branch stenosis.Results After stenting in the main branch of bifurcation lesions,four factors were found to be involved in causing side branch stenosis,which included:the plaque burden of both branches,the angle of bifurcation and the diameter of the side branch.The plaque burden of both branches was positively correlated but the biburcation angle and the diameter of the side branch were correlated to the formation of side branch stenosis.The severity of side branch stenosis after PCI could be represented by the regression equation:Y=0.48A-11.4B-0.23C+0.22D(Y:the degree of side branch stenosis after main branch stenting,unit:%;A:degree of pre-procedural side branch stenosis;B:diameter of the side brance;C:biburcation angle;D:the degree of pre-procedural main branch stenosis).Conclusion In bifurcation lesions,side branch stenosis after stenting in the main branch is related to plaque burden of both branches,diameter of the side branch and the bifurcational angle.Serious plaque burden in both branches,small side branch and sharper biburcation angle are more likely to cause side branch occlusion after main branch stenting.

OBJECTIVE To know the use of antibiotics in fever clinic of our hospital,and analyze whether it is reasonable.METHODS The situation was reviewed and analyzed that antibiotics were used for patients in fever clinic during the 4th quarter of 2005 by the doctor registry,original prescriptions,and data records of laboratory.RESULTS There were some unreadable aspects in the choice of antibiotics,the using method,drug combination etc in fever clinic of our hospital.CONCLUSIONS Fever clinic should enhance supervision management of the proper use of antibiotics.