Objective To investigate the treatment effect and some related fators of the improved lacrimal duct flushing technique for the adult patients with chronic dacryocystitis in the primary hospital.Methods Fifty -seven adult patients (fifty -seven eyes) with chronic dacryocystitis received the improved lacrimal duct flushing treatment.Fifty -seven patients were divided into two groups according to the first time to see a doctor and receive the improved lacrimal duct flushing treatment cooperated with drug application and assistant therapies.The effect and safety of the treatment and some related factors were analyzed.Results There was no statistical difference between the overall efficency of the two groups(A group 76.2%,B group 72.2%,χ2 =0.108,P =0.987 >0.05).The innero-cular pressures showed no statistical difference between pre -treatment and 1 month after treatment(the pre -treat-ment innerocular pressure:18.470,the post -treatment innerocular pressure:18.512,t =-0.315,P =0.754 >0.05).The correlation analysis between the conditions of lacrimal passages and treatment effect(r =0.814,r2 =0.663,P =0.002 <0.05),between the germiculture of the discharge of lacrimal sac and treatment effect(r =0.814, r2 =0.663,P =0.000 <0.05) showed statistical significance.Conclusion The improved lacrimal duct flushing technique cooperated with drug application and assistant therapies is safe and well effective to the adult patients with chronic dacryocystitis in the early stage.

The paper states the superiority of optimizing the teaching effect of clinical medicine by making use of information technology,analyzes the problems of information technology in optimizing the classroom teaching of clinical medicine,discusses the strategy of teaching with information technology in the aspect of classroom teaching structure,and thus reaches the effect of improving teaching efficiency and quality.

Calmodulin,as an important signaling regulatory protein,widely exists in eukaryotic cells and participates in a variety of physiological activities.Alzheimer's disease (AD) is a typical neurodegenerative diseasemostly affecting the old people.Senile plaques (SP) caused by amyloid protein deposition and neurofibrillary tangles (NTF) caused by over-phosphorylation of Tau protein in the brain are the two major neuropathological hallmarks of AD.Neuronal apoptosis induced by dysregulation of calcium homeostasis also plays a significant role during this pathological process.Recent studies have found that calcium and its downstream receptor,calmodulin,are closely associated with the pathogenesis and progress of Alzheimer's disease.This article reviews the current development and the latest research progress on the effects of calmodulin on β-amyloid protein generation and deposition,neurofibrillary tangle formation,synaptic plasticity in AD around the world,comprehensively discusses the role of calmodulin in the pathogenesis of Alzheimer's disease.

Objective To report the first case of ectodermal dysplasia/skin fragility syndrome in China. Methods The clinical data, transmission electron microscopic examination and immunohistochemical analysis of this patient were evaluated. Results The patient was a 3-year-old girl who presented increased skin fragility with trauma-induced, blisters and erosions, combined with short and sparse hair, finger-and toe-nail dystrophy and palmoplantar keratoderma. Transmission electron microscopy showed a loss of keratinocyte-keratinocyte adhesion, widening of intercellular spaces and a reduced number of hypoplastic desmosomes. Immunohistochemical analysis revealed a complete absence of staining for plakophilin 1. Conclusion Ectodermal dysplasia/skin fragility syndrome is a rare autosomal recessive inherited disease characterized by clinical manifestations as well as electron microscopic features and immunohistochemical evidence.

Objective To evaluate arterial reconstruction of traumatic iliac-femoral artery pseudoaneurysm in parenteral drug abusers.Methods Data of 21 consecutive patients who presented with iliac-femoral artery pseudoaneurysm with the diameter ranging from 3.0 cm～7.5 cm secondary to parenteral drug abuse from 2004 to 2007 were analyzed.Fifteen patients were male and the median age was 3 1.3 years.the aneurysm involved the common femoral artery and distal external iliac artery.Autologous greater saphenous vein was used as a graft for arterial reconstruction after iliac-femoral artery pseudoaneurysm excision through a single curved inguinal incision.Results The surgical procedure was successful in all 21 eases without intraoperative mortality and severe complications.All the 21 patients were free of postoperative claudication symptoms except 1 case with preoperative popliteal artery stenosis.Wound infection and tissue fistula developed in one ease.Ingunal incisional hematoma and cutaneous abnormal sensation developed in one each eases.Conclusions The use of autologous greater saphenous venous grafts for aaefial reconstruction after false aneurysm excision in drug abusers is safe and effective.The harvest of the greater saphenous vein is precondition of this precedure.These preliminary results indicate that the implementation of this technique offers advantages compared with the artery ligation alone without revascularization,that is frequently associated with later intermittent claudication.

Objective To investigate the therapeutic effects of botulinum toxin type A injection and acupuncture on periorbital wrinkles.Methods From May to September in 2015,24 patents were randomly divided into experimental and control group according to random number table:the patients in experimental group were treated with disposable acupuncture needles,20 min for each treatment,once a day,five times each course for courses,2 days interval between the two courses;the patients in control group were treated with 20 units of hotulinum toxin type A injection.The therapeutic results were observed 2 weeks after the treatment by the third-party doctor according to skin wrinkles grading.Results The periorbital wrinkles in both groups improved remarkably,and the wrinkle grading in control group was significantly lower than that in the experimental group (0.67±0.67 vs 1.33±0.61,P＜0.05).The skin quality and facial expression sensation in the experimental group improved significantly when compared with those in the control group.Conclusions Acupuncture can be used as a complementary treatment of periorbital wrinkles,and it improves the skin quality in terms of elasticity and color and keeps the natural facial expression sensation.

OBJECTIVE To study the clinical features of OSAHS patients closely associated with supine position. METHODS The clinical data of 105 patients with OSAHS diagnosed by overnight polysomnography(PSG)were retrospectively studied. The patients were divided in two groups: the positional patients(PP)group, those patients who had a apnea-hypopnea index(AHI) that was at least two times higher than the lateral AHI, and the non-positional patients(NPP)group, those patients in whom the AHI in the supine position was two times less than that in the lateral position, and the two groups were compared with age, BMI and the severity of OSAHS. RESULTS The difference of age and BMI were not significant between the two groups[(40.4?10.5)year versus(37.0?10.6) year,(28.2?3.8)kg/m2 versus(29.1?3.0)kg/m2]. There was significantly different in AHI between two groups[(36.8?25.4)/h versus (51.2?29.0)/h ]. AHIsupine and AHInot-supine was significantly different in mild and moderate OSAHS patients [(23.9?13.8) /h versus(12.4?10.1)/h ]. CONCLUSION Mild and moderate OSAHS patients are mainly PP. Positional therapy should play an important role in treatment of mild and moderate patients.

Objective·To compare the stress distribution at abutments, edentulous ridge, and peri-implant tissue under the vertical load between the RPI-type removable partial denture supported by implants with different diameter and the conventional RPI-type removable partial denture using a three-dimensional photoelastic method. Methods·The mandibular Kennedy I type denture defect models were fabricated according to the standard mandibular model. Four Straumann system soft tissue level implants with different diameters (two 4.1 mm implants and two 3.3 mm implants) were implanted into the bilateral first molar areas. Planting nails and epoxy resin teeth were inversely put into the mandibular silicone rubber molds to fabricate the epoxy resin photoelastic models and the regular neck (RN) healing abutments were screwed into the implants. A simulated alveolar mucosa with thickness of 2mm and a conventional RPI-type removable partial denture were placed on the epoxy resin models with or without implants. Then a force of 1 kg was vertically applied by a bite force loading device which fixed the model and denture in the centric occlusion. After the stress was frozen, model slices at different areas were cut and the stress fringes were observed. The stress was calculated according to the fringe value of per unit thickness. Results·For the conventional RPI-type removable partial denture, the maximum stress of distal abutment was mainly concentrated on the apical regions and the maximum stress of edentulous ridge was concentrated on the first molar area, particular on the lingual side of alveolar bone. For the implant-supported RPI-type removable partial denture, the maximum stress of distal abutment was lower than that of the conventional RPI-type removable partial denture, and the maximum stress of edentulous ridge (without the implants) was similar to that of abutment and supporting tissues and was lower than that of the conventional RPI-type removable partial denture. The stress around the implant was the largest and the peri-apical stress of implant was greater than the neck stress of implant. Meanwhile, the maximum stress around the implant was increased with the decrease of implant diameter. Conclusion·Compared to the conventional RPI-type removable partial denture, removable partial dentures supported by implants are more stable with a more balanced stress distribution in supporting tissues, thus benefit the health of abutments and supporting tissues.

0 05),increased markedly at R 3 in group C (P

0 05) Conclusions Cervical epidural for postoperative analgesia can effectively inhibit the stress response in patient after the replantation of amputated fingers but dose not affect respiratory function Fentanyl provides best analgesia with less adverse effects and is suitable for postoperative analgesia in these patients