Introduction: This cross-sectional study aims to determine the provision of foods according to NOVA classifications (an ultra-processed classification), to assess contribution of sodium and added sugar availability in each of NOVA food groups, and to evaluate nutritional status as well as to determine the relationship between sodium, added sugar availability of each NOVA foods groups and nutritional status among adults in Terengganu. Materials and methods: About 200 respondents aged between 18 and 59 years old from Kuala Nerus, Terengganu were recruited. Their dietary intake from two days of 24-hour dietary recall underwent NOVA classification and analyzed through Nutritionist Pro. All respondents had their blood pressure and fasting blood glucose taken. Spearman&rsquo;s rank correlation was used to evaluate the relationship between sodium and added sugar each of NOVA food groups and the nutritional status. Results: The total energy intake of the respondents was 1818 kcal + 375.05 per day. The energy contribution of ultra-processed group was 24%. The sodium and added sugar contribution of ultra-processed group were 26% and 63%, respectively. The mean blood pressure and median of blood glucose were normal at 114/79 mmHg and 5.3 mmol/L, respectively. No significant correlation was found between sodium, added sugar availability of each NOVA food groups and nutritional status at p<0.05. Conclusion: Further studies involving vigorous research design need to be carried out in order to really understand the implication of ultra-processed food consumption towards the nutritional status of Malaysian population, as highlighted in the Malaysian Nutrition Research Priorities (2016-2020).

Parkinson disease （PD） is a neurodegenerative disease characterized by progressive extrapyramidal symptoms and a range of non-motor symptoms， and in addition to the fluctuation of motor symptoms， there are also fluctuations of non-motor symptoms. Non-motor symptom fluctuations have a significant impact on the quality of life of patients with Parkinson&rsquo;s disease and may be independent of motor symptom fluctuations. At present， scholars in China do not pay much attention to non-motor fluctuations， and therefore， this article reviews the foreign studies on non-motor fluctuations in recent years.
Parkinson Disease

OBJECTIVE To study the effect of different doses of aspirin on clinical efficacy in acute stage of Kawasaki&rsquo;s disease, and to explore the optimal dose of aspirin. METHODS A total of 150 patients suffered from Kawasaki&rsquo;s disease were randomly selected by hospital information system from March to May 2022 for retrospective analysis. According to different doses of aspirin, they were divided into three groups: high dose group(>50 mg·kg−1·d−1), medium dose group(30−50 mg·kg−1·d−1) and low dose group(<30 mg·kg−1·d−1). The antipyretic time, the incidence of non-response to intravenous human immunoglobulin, the improvement of laboratory indexes and prevalence of adverse drug reaction were compared among the three groups. RESULTS There was no significant difference in body temperature recovery among the three groups under different doses of aspirin. There was no significant difference in patients with non-response to intravenous human immunoglobulin among the three groups. Before treatment, there were no significant differences in white blood cell(WBC) count, blood platelet(PLT) count and C-reactive protein(CRP) concentration among the three groups. After treatment, the count of WBC, PLT and CRP in the three groups was significantly improved compared with that before treatment, and the difference was statistically significant(P<0.05). However, there was no significant difference in the above indexes among the three groups after treatment. There was a higher incidence of adverse reactions in children treated with medium or high dose aspirin. CONCLUSION Different doses of aspirin combined with intravenous human immunoglobulin have good therapeutic effect on Kawasaki&rsquo;s disease, but considering the safety and economy of aspirin, low dose administration is recommended.

Objective To evaluate the efficacy and safety of midazolam combined with dexmedetomidine for sedation during magnetic resonance imaging(MRI)examination in children.Methods The medical records of children who underwent sedated MRI examinations at the Sedation Center of Children's Hospital Affiliated to Shandong University from August 2021 to July 2022 were collected.The patients were divided into three groups based on age:Infant group(age≤1 year old,922 cases),toddler group(1 year old

[Abstract] Objective: To explore the inhibitive effect of asiatic acid (AA) on paclitaxel (PTX)-resistant glioma cells and its possible mechanism. Methods: The effects of AA on the proliferation and apoptosis of glioblastoma U87MG cells were detected by CCK-8 assay, Real-time quantitative polymerase chain reaction (qPCR) and Western blotting. The drug-resistant glioma cell line PR-U87MG was established by culturing the cells in concentration-increasing PTX. With U87MG cells as control, the PTX-resistance of PR-U87MG cells was confirmed using CCK-8 assay, and the mRNA and protein levels of MDR1 and LRP were measured with qPCR and western blotting. PR-U87MG cells were treated with AA, PTX or AA+PTX, and then the cell viability and apoptosis of each group were measured with CCK-8 assay, qPCR and Western blotting. Results: PTX-resistant PR-U87MG cell line was successfully established. AA inhibited the viability of U87MG and PR-U87MG cells in a dose-dependent manner (P<0.01) and significantly promoted their apoptosis (P<0.01). Compared with the group treated with AA or PTX alone, the group treated with the combination of AA and PTX had significantly decreased protein levels of PARP1 (P<0.01), drug-resistant related proteins (Pgp-1 and LRP [lung resistance protein], all P< 0.01), and markedly increased caspase 3 (P<0.01). Conclusion: AA could effectively enhance the sensitivity of U87MG cells to PTX, and the mechanism may be related to the suppressed expression of drug efflux-associated proteins Pgp-1 and LRP.

Henoch-Schönlein purpura (HSP) is the commonest vasculitis in children, typically affecting children aged three to ten years.[1] It is a multi-systemic vasculitis mediated by type III hypersensitivity with deposition of immunoglobulin. An immune complex-mediated vasculitis affects small vessels of the skin, joints, kidneys, and gastrointestinal (GI) tracts. HSP is usually a self-limiting condition and resolves within six to eight weeks.[1] HSP tends to involve the GI tract and symptoms may occur before skin manifestations. Proximal small bowel and distal ileum are the sites that usually involved.[2,3] Colicky abdominal pain is the predominant GI manifestation and can be debilitating. Severe GI complications such as massive GI bleeding, intussusception, protein losing enteropathy, and pancreatitis can uncommonly occur.[2,4] Imaging is often required in the evaluation of HSP with GI involvement. However, there is little pediatric literature on the role of point-of-care ultrasound (POCUS) by pediatric emergency physicians in the identification of pneumatosis intestinalis (PI) in HSP.

The PleurX catheter was developed to facilitate long-term intermittent drainage of malignant pleural effusion or ascites. For palliation, it is important that the process of insertion is safe and that this catheter remains complicationfree so as to improve end-of-life quality. We show that this catheter can be safely inserted and discuss methods to reduce infection, which was the most common complication. Our article hopes to enlighten clinicians, patients and their caregivers of this device as a treatment option in palliative patients. Proper case selection and caregiver training are essential in ensuring a successful outcome.

Objective Sentinel headache（SH） refers to new-onset headache or existing headache with altered characteristics that occurs within seven days before stroke in patients， and this study aims to investigate the incidence rate and clinical features of SH in stroke patients and its association with prognosis. Methods A total of 145 stroke patients who were admitted to Department of Neurology， The First Affiliated Hospital of Xi&rsquo;an Jiaotong University， from August 2022 to April 2023 were enrolled based on inclusion/exclusion criteria， and general information was collected. According to the presence or absence of SH， they were divided into headache and control group. The features of SH were summarized， and follow-up was performed after 1 year to analyze the association between SH and prognosis. Results Among the 145 patients with stroke，30（20.7%） developed SH， with the subtypes of intracerebral hemorrhage（9 patients， 25.7%）， cerebral infarction （15 patients，18.9%）， transient ischemic attack（3 patients，14.3%）， and subarachnoid hemorrhage （3 patients， 30.0%）. Conclusion SH may occur in all stroke patients， with a prevalence rate of 20.7%. The manifestations of SH include migraine-like headache， tension-type headache， and cluster-like headache. The results of this study do not establish an association between SH and 1-year prognosis in stroke patients，and further studies are needed in the future.
Stroke ; Prognosis

Objective     To analyze the clinical characteristics of the Guang&rsquo;an Omicron epidemic and summarize the management experiences and practices in pandemic prevention and control of major infectious diseases. Methods     Retrospective analysis was performed on patients infected with coronavirus disease (COVID-19), afterwards treated and observed in the isolation ward of Guang&rsquo;an People&rsquo;s Hospital and the shelter of Guang&rsquo;an City from May 9 to June 26, 2022. The characteristics of patients at different age stages and the related factors affecting the severity, re-positive and negative conversion was analyzed. Results     Finally 1 278 patients were collected, including 508 males and 770 females, with an average age of 41.3±22.6 years. Among them, 1 054 patients were asymptomatic carriers. The overall severe rate was 0.86%, the severe rate of the high-risk group was 3.06%. The median negative conversion time was 10.0 days and re-positive rate was 7.36%. Patients aged>60 years were 2.589 times more likely to have a longer negative conversion time than those aged≤60 years (95%CI 1.921-3.489, P<0.001). Conclusion     The clinical characteristics of Guang&rsquo;an COVID-19 epidemic are mainly that the elderly with high risk factors are more likely to develop severe cases, have longer clearance time, and re-positve is more likely to occur.