1.Children with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome:two cases report
Journal of Clinical Pediatrics 2015;(3):258-263
ObjectiveTo discuss the clinical features, diagnosis and treatment of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome in children.Methods The clinical features and treatment process of two children with MELAS were retrospectively analyzed.ResultsThe main clinical features of MELAS were stroke-like epi-sodes, seizure, visual anomaly and lactic acidosis. Cephalic MRI ifndings performed during episode periods were in accord with the typical radiographic features of MELAS. Gene testing on the two children and their mothers showed the point mutation of A3243G in mitochondrial genome. The symptoms were improved signiifcantly after energy supply and corticosteroid treatment. Conclusions MELAS syndrome is easy to be misdiagnosed due to the varied clinical features. The diagnosis depends on the musclebiopsy and gene testing. Corticosteroid therapy is effective for MELAS syndrome.
2.Clinicopathologic study on p185 and p16 proteins in human breast cancer
Acta Universitatis Medicinalis Anhui 2001;(1):24-26
Objective To investigate the biological significance of p185 and p16 in breast cancer. Methods Immunohistochemical S-P method was used to detect the expression of p185 and p16 proteins in 59 breast carcinomas,and their relations to clinicopathologic features were analyzed. Results The positive rates of p185 and p16 were 47% and 34% respectively. No significant association was evident between the two proteins. There was also no significant relation between p16 expression and clinicopathologic features. p185 positive rate was 64% in the group of lymph-node involvement that was higher than that being 32% lymph-node negative one (P<0.05). Conclusion p185 and p16 may play important roles independently in the development of breast cancer through different pathways. p185 detection is of important value in breast cancer.
3.Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice.
Yun-chun LUO ; Qiang-wei XIANG ; Qiang WANG
Chinese Journal of Pediatrics 2008;46(11):868-869
Animals
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Asthma
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drug therapy
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metabolism
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Inflammation
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Lung
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drug effects
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metabolism
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pathology
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Male
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Mice
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Mice, Inbred BALB C
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Phytotherapy
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Pyrazines
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pharmacology
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therapeutic use
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RNA, Messenger
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metabolism
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rho GTP-Binding Proteins
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metabolism
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rho-Associated Kinases
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metabolism
4.Updated treatment of erectile dysfunction after prostatectomy.
Qiang DONG ; De-yi LUO ; Hao ZENG
National Journal of Andrology 2015;21(6):483-488
The incidence rate of erectile dysfunction (ED) is reportedly as high as 30-90% after radical prostatectomy for prostate cancer, which seriously affects the patients' quality of life. Penile rehabilitation is defined as the use of any drug or device at or after radical prostatectomy to maximize erectile function recovery. A variety of treatment options are available for post-prostatectomy ED patients, including oral phosphodiesterase 5 inhibitors (PDE5I) , intracorporal injections, vacuum erection device, and penile prosthesis. This article presents an overview of the currently used methods for the drug treatment and penile rehabilitation of the ED patients after radical prostatectomy. It seems proper to recommend daily use of a vacuum erection device plus oral PDE5I in the early postoperative period. For those who fail to respond to this therapy, intraurethral alprostadil, intracorporal injections, or a penile prosthesis could be considered.
Alprostadil
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administration & dosage
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Combined Modality Therapy
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Erectile Dysfunction
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etiology
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therapy
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Humans
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Male
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Penile Erection
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Penile Prosthesis
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Phosphodiesterase 5 Inhibitors
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administration & dosage
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Prostatectomy
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adverse effects
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Quality of Life
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Recovery of Function
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Vacuum
5.Analysis of curative effects of Pudilan Xiaoyan Koufuye on patients with eOLP and ROU
Weichao LIANG ; Qiang LUO ; Hui JI
Chinese Journal of Biochemical Pharmaceutics 2017;37(2):129-132
Objective To investigate the clinical effect of the treatment of erosive oral lichen planus and recurrent aphthous ulcer by using Pudilan Xiaoyan Koufuye.Methods The clinical data of 138 cases of oral mucosal diseases were retrospectively analyzed from September 2015 to June 2016 in our hospital, eOLP patients 50 cases, 11 cases in the control group one and the control group two, 28 cases in the observation group; ROU patients 88 cases, 21 cases in the control group one and the control group two, 46 cases in the observation group.The control group one was treated with topical western medicine, while the control group two was treated with Pudilan Xiaoyan Koufuye,and the observation group was treated with local topical spray and Pudilan Xiaoyan Koufuye, compared the total effective rate, VAS score and mucosal congestion in different groups of patients with oral diseases, and to observe the adverse reactions of the patients during the treatment.Results After one week of treatment, the total effective rate of treatment was significantly different between eOLP patients and ROU patients (P<0.05),the total effective rate of the observation group was higher than that of the control group one and the control group two ( P <0.05 ) .After two weeks of treatment, the total effective rate of eOLP patients was significantly different, and the total effective rate of observation group was higher than that of control group one (P<0.05),there was no significant difference among the ROU patients.The degree of mucosal hyperemia and the VAS score in the observation group were significantly different from those in the control group one and control group two in the patients with eOLP and ROU ( P <0.05 ) .No significant adverse mucosal staining occurred in all groups of patients, and there was no discontinuation due to obvious adverse reactions.Conclusion Pudilan Xiaoyan Koufuye adjuvant treatment of eOLP and ROU patients with short-term effect is significant, can improve the total effective rate of treatment, and no serious adverse reactions, high safety.
6.Changes of local dentition with fixed implant prostheses.
Qiang LUO ; Lei ZHANG ; Qiu-fei XIE
Chinese Journal of Stomatology 2013;48(5):317-320
7.Exercise induced asthma.
Yun-chun LUO ; Qiang-wei XIANG
Chinese Journal of Pediatrics 2005;43(6):423-425
Anti-Asthmatic Agents
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therapeutic use
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Asthma, Exercise-Induced
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diagnosis
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epidemiology
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physiopathology
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therapy
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Child
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Constriction, Pathologic
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drug therapy
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etiology
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physiopathology
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Diagnosis, Differential
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Glucocorticoids
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therapeutic use
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Humans
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Risk Factors
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Treatment Outcome
8.Preliminary study in detecting acute severe pancreatitis with contrast enhanced ultrasound
Yue ZHONG ; Yan LUO ; Qiang LU
Chinese Journal of Ultrasonography 2010;19(6):495-497
Objective To investigate the accuracy of contrast enhanced ultrasound (CEUS) in diagnosing acute severe panereatitis.Methods Thirty three patients with acute severe pancreatitis were enrolled in the study and all of them underwent CEUS and spiral computed tomography(CT) scan.CT was taken as gold standard in acute severe pancreatitis diagnosis.CEUS were done within 72 hours after CT scan.Results Compared with CT, the sensitivity, specificity,accuracy, positive predictive value,and negative predictive value of CEUS for detecting the necrosis of pancreas were 90%, 95%, 94%, 90% and 95%respectively.The sensitivity, specificity, accuracy, positive predictive value,and negative predictive value of CEUS in diagnosing severe acute pancreatitis were 85%, 92%, 88%, 94% and 80% respectively, while 37% ,86% ,58%, 78%, 50% for conventional ultrasound respectively.Conclusions CEUS is accurate in detection of pancreatic necrosis and diagnosis of acute severe pancreatitis.
9.Surgical Intervention Combined with Steroid Therapy on Persistent Jaundice in Infantile Hepatitis
Journal of Applied Clinical Pediatrics 2006;0(20):-
Objective To investigate the effect of surgical intervention combined with steroid therapy on infantile hepatitis(INS) with persistent jaundice.Methods Twenty-two patients (19 males,3 females,aged 2-6 months) with persistent jaundice(therapy group) were admitted into hospital in the period of Jan.2007-Dec.2008.The patients were performed with surgical intervention after they were confirmed with diagnosis as INS.Then,sodium chloride,gentamicin and Dexamethasone were used to irrigate the biliary tract during and after the operation for 14 days.Three days after operation,20 mg,15 mg,10 mg,5 mg of methylprednisolone were administered intravenously to the patients every 3 days,followed with 4 mg/(kg?d) prednisone by oral for 2-3 months.The 17 cases of INS with persistent jaundice were treated with medicine as control(control group).By following-up,the jaundice free and 2 years survival rate of 2 groups were compared by counting the cases of jaundice free and recording the survival time.Results Two cases of 22 patients performed with surgical intervention were diagnosed as biliary atresia and others were INS,90.0% patients were free of jaundice in surgical intervention combined with steroid therapy group,which was higher than that in control group(52.9%,P