No abstract available.
Protein Kinases

Structural information has been a major concern for biological and pharmaceutical studies for its intimate relationship to the function of a protein. Three-dimensional representation of the positions of protein atoms is utilized among many structural information repositories that have been published. The reliability of the torsional system, which represents the native processes of structural change in the structural analysis, was partially proven with previous structural alignment studies. Here, a web server providing structural information and analysis based on the backbone torsional representation of a protein structure is newly introduced. The web server offers functions of secondary structure database search, secondary structure calculation, and pair-wise protein structure comparison, based on a backbone torsion angle representation system. Application of the implementation in pair-wise structural alignment showed highly accurate results. The information derived from this web server might be further utilized in the field of ab initio protein structure modeling or protein homology-related analyses.
Databases, Protein ; Protein Structure, Secondary

No abstract available.
Myocardium* ; Protein Kinase C* ; Protein Kinases*

Databases, Protein ; Protein Structure, Secondary ; Proteins ; chemistry

No abstract available.
C-Reactive Protein* ; Pregnancy*

No abstract available.
Apoptosis* ; Fas Ligand Protein

The latest measure of the relative evolutionary age of protein structure families was applied (based on taxonomic diversity) using the protein structural interactome map (PSIMAP). It confirms that, in general, protein domains, which are hubs in this interaction network, are older than protein domains with fewer interaction partners. We apply a hypothesis of 'biological network evolution' to explain the positive correlation between interaction and age. It agrees to the previous suggestions that proteins have acquired an increasing number of interaction partners over time via the stepwise addition of new interactions. This hypothesis is shown to be consistent with the scale-free interaction network topologies proposed by other groups. Closely co-evolved structural interaction and the dynamics of network evolution are used to explain the highly conserved core of protein interaction pathways, which exist across all divisions of life.
Humans ; Protein Structure, Tertiary

No abstract available.
C-Reactive Protein* ; Tocolysis*

No Abstract Available.
Fas Ligand Protein* ; Keratoconus*

No abstract available.
C-Reactive Protein*