A case of lymphocytoma cutis, the circumscribed form in 9 year-old girl is reported. This is seldom conclusive without histological examinatien for a wide variety of conditions has to be considered. The circumscribed form usually responds rapidly to radiotherapy, although recurrence is possible and good results from the use of procaine penicillin especially in the disseminated form. In this case, I experienced good results from CO, slush and topical application of 0.25 % fluocortolone 3 times a day without recurrence in 3 months after treatment.
Child ; Female ; Fluocortolone ; Humans ; Penicillin G Procaine ; Pseudolymphoma* ; Radiotherapy ; Recurrence

Anesthetics, Local* ; Animals ; Papillary Muscles* ; Procaine ; Rats* ; Tetracaine

Anesthetics, Local* ; Animals ; Papillary Muscles* ; Procaine ; Rats* ; Tetracaine

Penicillin is still the first choice of drug in the treatment of gonorrhea. The ever lowering sensitivity of Neisseria gonorrhoeae to penicillin and the emergence of PPNG (Penicillinase Producing Neisseria Gonorrhoeae) in the Far East and other parts of the world neceessitate reapprisal of treatrnent schedules with penicillin for gonococcal infections. In Korea, no authentical study in this regard has been done recently. The presence of intracellular gram r.egative diplococci in urethral smear as weIl as the presence of oxidase positive typical, round, convex, smooth, glistening, tratmslucent, greyish colonies of 0.5 to 2mm in diameter a 24 hours composed of grarn negative diplococci are used for presump'ive evidence of gonococccal infection 224 male patients with acnte uncomplicated gonococal infections were treated one of following regimens. Regimen A: 4.8mega unit combicillin (3.6mega unit procaine penicillin+l.2 mega unit sodium penicillin) i.m.. preceded by 1gm probenecid p.o., Regirnen B: 4.8 mega unit procaine penicillin i.m. preceded by 1gm probenecid P.O. Regimen A showed 14 failures(11.3% arnong 124. Regimen B showed 19 failures (19%) among 100 It is suggested that in Korea sesnsitivity to penicillin of Yeisseria gonorrhoeae is quite low.
Appointments and Schedules ; Far East ; Gonorrhea ; Humans ; Korea ; Male ; Neisseria ; Neisseria gonorrhoeae ; Oxidoreductases ; Penicillin G Procaine ; Penicillins* ; Probenecid ; Procaine ; Sodium

We reported previously that, combined with l. 0 gm of probenecid, sodium penicillin G. 4, 0 m.u.i.m. was slightly less effective than procaine penicillin G. 4. 8 m.u. i.m. in the treatment of uncomplicated male gonorrhea. We now present the effect of double dose of sodium penicillin G. in the treatment of uncomplicated gonorrhea. The subjects were 262 male patients with uncomplicated gonoccccal urethritis at the VD clinic of Choong Ku Public Health Center in Seoul during 5 months period from January to May 198l. The following criteria were used to identify gonococcal infection - Gram negative intracellular diplococci in urethral smear and/or oxidase positive typical colony formation on Thayer-Martin media composed of Gram negative diplococci. They were given 4.0 m.u. sodium penicillin G. i.m. proceeded 15 to 30 min. by 1. 0 gm. probenecid p.o.. Four hours later, same amount of sodium peniciIlin G. i.m. was repeated. Concornitant eomparison of procaine penicillin G. was not done because of recent una,vailability of the drug in Korea. To avoid pain, the drug is dissolved in 6 ml of normal saline plus 2 ml of 2% lidacaine. One hundred eighty five patients were able to be followed 3 to 7 days after the treatment. There were .24 (13%) failures and 17 (10. 6%) postgonococcal urethritis. During this study, l4 strains of PPNG (Penicillinase Producing Keisseria Gonarrhoeae) were detected with chromogenic cephalosporin slide method. There were 10 (5. 8%) failures among 171 patients with urethritis caused by non-PPNG.
Gonorrhea* ; Humans ; Korea ; Male* ; Oxidoreductases ; Penicillin G Procaine ; Penicillin G* ; Probenecid ; Public Health ; Seoul ; Sodium* ; Urethritis

In order to find highly active antidiabetic lead compound, sixteen 4-aminobenzoic acid derivatives were designed and synthesized directly through Mannich reaction in the solution of ethanol at 15-35 degrees C with facile method, mild reaction condition and high yield (45%-90%). Fifteen of them are new compounds. Their structures were confirmed by 1H NMR, 13C NMR, IR, ESI-MS and HR-MS. Alpha-glucosidase inhibitory activity of these compounds indicated that most of these compounds possess the activity with the order: 2c > 2b > 2h > 1a > 1f. The structure-activity relationship of these 4-aminobenzoic acid derivatives was also discussed.
4-Aminobenzoic Acid ; chemical synthesis ; pharmacology ; Drug Design ; Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents ; chemical synthesis ; pharmacology ; Mannich Bases ; chemistry ; Molecular Structure ; Structure-Activity Relationship ; alpha-Glucosidases ; metabolism ; para-Aminobenzoates

We report one case of 1 month old male with early congenital syphilis Who represented the characteristic clinical features and laboratory findings including darkfield examindtion and quantitative VDRL test. The histopathologic findings of the patients skin biopsy specimen showed extravasation of erythrocytes and perivascular infiltration of plasma cells were found. in addition to the previous described findings by Fraser. He was managed by daily injection of 200,000 units of aqueous procaine penicillin for 8 days and then three injections of 150,000 units of PA.M at two days intervals with excellent effect
Biopsy ; Erythrocytes ; Humans ; Infant, Newborn ; Male ; Penicillin G Procaine ; Plasma Cells ; Skin ; Syphilis, Congenital*

Although the penicillin is still the first choice of drug in the treatment of gonorrhea in most areas of the world, Neisseria gonorrhoea has become increasingly less sensitive to penicillin preparations. The proportion of such strains also varies from region to region. Sodium penicillin G. is a short acting preparation which enables to attain quick high blood level. The reason for combining the quick acting sodium penicillin G. with probenecid is that latter inhibits renal excretion of penicillin and maintains effective serum penicillin levela long enough to extinguish gonococcal infections. The subjects were 265 male patients with uncomplicated gonococcal urethritis at the VD clinic of Cboong Ku Public Health Center in Seoul during 5 months period from September 1980 to January 1981. The following criteria is used to identify gonococcal infection Gram negative intracellular diplococci in urethral smear and/or oxidase positive typical colony formation on Thayer-Martin media composed of Gram negative diplococci. The 265 patients were divided in two groups(A and B group). They were administered an oral dose of 1.0 gm. probenecid and, 15 to 30 min. later, 4.0 m.u. of sodium penicillin G. i.m. in A-group(152) and 4.8 m.u. procaine penicillin G. i.m. in B-group(113). Only those who were able to be followed up 3 to 7 days after treatment were contained for final analysis(A-group:108, B-group:88), A-group showed 22 failures(20.4%), and B-group 9 failures(10.2%). A significant difference is found between the two groups(P<0.05). Incidence of postgonococcal urethritis was 6(7.0%) in A-group and 5(6.3%) in B-group(P>0.05). We suggest a repeated injection 3 to 4 hours later or increased amonuts of sodium penicillin G. might give better result in the treatment of uncomplicated gonorrhea.
Gonorrhea* ; Humans ; Incidence ; Male* ; Neisseria ; Oxidoreductases ; Penicillin G Procaine ; Penicillin G* ; Penicillins ; Probenecid ; Public Health ; Seoul ; Sodium* ; Urethritis

Among all of the cerebrovascular problems that which has the highest mortality and worst prognosis is the problem of intraventricular hemorrhage. The mortality is highest immediately following the hemorrhage. Because direct surgical intervention is thought to be very dangerous in patients with intraventricular hemorrhage most of these patients have been treated conservatively. This study gives the results of evacuation of the intraventricular blood plus the placement of external draninage catheters which decrease the intraventricular pressure and provide and outlet for the blood should the patient have further hemorrhage. Such a procedure is associated with clinical improvement which better prepares such patients for subsequent surgical treatment. Eighteen patients who had intraventricular hemorrhage between June 1973 and April 1974 are analyzed as to the results of this operative treatment. Also the literature concerning this new method is reviewed. The operative procedure was as follows: Under local anesthesia using 1% procaine unilateral or bilateral burr holes were made in the frontal area. Ventriculostomy was made through these oles. The ventricle was irrigated with physiologic saline removing the hematoma or the bloody ventricular fluid. The irrigation was continued until the fluid became relatively clear. Following the initial irrigation, the cannular was removed and a Nelaton catheter placed into the ventricle. The catheter was fixed to the scalp and connected to a drainage bottle under aseptic conditions. The ventricular drainage was maintained at 200 mmH2O for 7-10 days. Prior to surgery 2 million units of procaine penicillin was injected into the ventricle. Postoperatively, 5mg of Gentamycin was injected through the catheter twice a day. Surgical drainage of the ventricle was done 3 hours to 7 days after the onset of clinical signs of hemorrhage. The external ventricular drainage was maintained for an average of 7.0 days. RESULTS: 10 patients(56%) improved and could be discharged. 4 died of recurrent intraventricular hemorrhage, of gastrointestinal bleeding, or of myocardial infarction during hospitalization. However, all of these 4 patients showed some clinical improvement following the operative procedure. Only "4" patients expired after surgery. This mortality of 44% is considerably less than the usually found mortality of 80-100% for intraventricular hemorrhage and 60-70% in subarachnoid hemorrhage. On the basis of this study a more active treatment of patients with intraventricular hemorrhage, including operative drainage of the ventricles is proposed.
Anesthesia, Local ; Catheters ; Drainage* ; Gentamicins ; Hematoma ; Hemorrhage* ; Hospitalization ; Humans ; Mortality ; Myocardial Infarction ; Penicillin G Procaine ; Procaine ; Prognosis ; Scalp ; Subarachnoid Hemorrhage ; Surgical Procedures, Operative ; Ventricular Pressure ; Ventriculostomy

The purpose of the present study is to find out whether the ophthalmotonic consensual reaction really exists and through what channel the reaction is brought about in rabbits. Twenty-eight pigmented male rabbits were divided into four groups of seven rabbits each, and the intraocular pressure of each eye was measured at designated times in each group with a Mueller electronic tonometer under topical anesthesia (0.5% tetracaine hydrochloride). Retrobulbar anesthesia and compression were performed in each group as follows: Group 1: From 56 minutes to 60 minutes after the experiment had begun, the right eye was compressed for 4 minutes with a 50 gm weight by means of a Baillart ophthalmodynamometer Group 2: About one hour after the experiment had begun, 1.0 cc of 2% procaine hydrochloride was given by retrobulbar injection on the right side. Digital massage after retrobulbar injection was avoided and epinephrine was not employed, because they might influence the intraocular pressure. Group 3: After retrobulbar anesthesia had been performed for the right eye at 40 minutes, this eye was compressed by the above described method from 85 minutes to 90 minutes after the experiment had begun. Group 4: After retrobulbar anesthesia had been performed in the left eye at 40 minutes, the right eye was compressed by the above described method from 86 minutes to 90 minutes after the experiment had begun. The data of each experimental group were analyzed statistically by means of the t-test. Four groups of tonometric studies were done with the following results: 1. After the right eye had been compressed with a 50 gm, weight for 4 minutes, the right intraocular pressure was found to be lowered and then immdiately elevated. The intraocular pressure in the left eye was lowered beginning about 20 minutes after the right eye compression, and this phenomenon may be considered as the ophthalmotonic consensual reaction. 2. After retrobulbar anesthesia with 1.0 cc of 2% procaine hydrochloride had been performed for the right eye, the intraocular pressure was found to be lowered, but that of the left eye showed a slight rise and maintenance of the elevated pressure. 3. When the right eye was compressed after retrobulbar anesthesia had been performed, the grade of rising of the intraocular pressure was lower than when retrobulbar anesthesia had not been performed. The intraocular pressure in the left eye showed no significant change, so it can be postumted that the afferent pathway of the ophthalmotonic consensual reaction was blocked by the retrobulbar anesthesia in the compressed right eye. 4. When the right eye was compressed after retrobulbar anesthesia had been performed previously in the left eye, the change of the intraocular pressure in the right eye showed no difference as when retrobulbar anesthesia had not been performed in the left eye. The intraocular pressure in the left eye showed a similar change as when the right eye had not been compressed, so it can be postulated that the efferent pathway of the ophthalmotonic consensual reaction was blocked by the retrobulbar anesthesia in the non-compressed left eye.
Afferent Pathways ; Anesthesia ; Efferent Pathways ; Epinephrine ; Humans ; Intraocular Pressure ; Male ; Massage ; Procaine ; Rabbits* ; Tetracaine