Dietary factors play important roles in the initiation and development of breast cancer. There are numerous articles on this topic and most of them focus on the associations between dietary fat, vegetable, fruit, alcohol, phytoestrogen intakes and breast cancer. Different conclusions have been reached.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.

In foreign countries,ascorbic acid (vitamin C) has been used as a complementary drug in cancer treatments for many years.Although it has not been accepted by mainstream medicine,a growing number of in vitro and in vivo experiments indicated that pharmacological concentrations of ascorbic acid could inhibited cancer cell proliferation and promote cell apoptosis.In this paper,the anti-cancer effect of ascorbic acid weer reviewe.d.

Objective: To study the practical value of a new techinigue of perforating vein ligation. Methods: Enlightened by Subfascial Endoscopic Perforator, we isolate perforating vein in subfasica through little incision, and then ligate and cut perforating vein. The change of the symptoms and signs were observed, and the clinical severity grade of pre-operation were compared with that of post-operation. Results: The symptoms and signs of patients are improved after operation, and the clinical severity grade of postoperation of the patients was significant different, comparing with that of pre-operation. Conclusion: The effect of perforating vein ligation through little incision at subfascia is effective and its complications are few.

OBJECTIVE:To probe into the status quo and the tendency of the utilization of psychotropic drugs in our hospital. METHODS:The consumption sum,DDDs and the daily drug cost of psychotropic drugs from 2006 to 2008 were analyzed statistically in this retrospective study. RESULTS & CONCLUSION:The consumption sum of psychotropic drugs in our hospital assumed year-on-year increase tendency. The DDDs of the first generation of psychotropic drugs remained stable. The consumption amount of the non-first generation of antipsychotic drugs increased year on year,with risperidone showing the most rapid increase. Fluoxetine,venlafaxine and paroxetine took the lead among all the antidepressant drugs used. However,the consumption amount of tricyclic antidepressants decreased markedly. Benzodiazepine took the lead among all the antianxiety drugs.

Objective To study the role of dependence of stromal cell derived factor‐1(SDF‐1) on myocardial infarction an‐giogenesis and function recovery .Methods The rats were randomly divided into the test group (65 cases) and the treatment group (64 cases) ,in which 5 rats in the test group were randomly killed on 1 ,2 ,4 ,7 ,14 ,28 d before and after myocardial infarction(infarc‐tion group) and the SDF‐1 protein level was detected .At the same time the sham operation group(5 cases) was set up;64 rats in the treatment group were randomly divided into four groups ,16 cases in each group ,which were infarction+SDF‐1 group ,infarct+anti‐SDF‐1 group ,infarct+normal saline group and normal+normal saline group .After the corresponding processing in each group ,the SDF‐1 levels after myocardial infarction ,MSCs homing amount ,neovascularization density ,EF and FS levels were compared among various groups .Results The SDF‐1 level after 1-7 d in the infarction group was significantly higher than that in the sham opera‐tion group ,and reached a peak level ,then decreased gradually and restored to normal on 14 d ,the difference was statistically signifi‐cant (P<0 .05) .The MSCs homing amount and neovascularization density level in the SDF‐1 treatment groups were significantly higher than those in other groups ,which in the infarction+anti‐SDF‐1 group were significantly lower than those in the infarction+normal saline group ,the differences were statistically significant (all P<0 .05) .The cardiac function improvement situation in the infarction +SDF‐1 group was significantly better than that in other groups ,the difference was statistically significant (P<0 .05) . Conclusion SDF‐1 can promote angiogenesis in myocardial infarction ,also improve the heart function .

BACKGROUND:Silver sulfadiazine water gel dressings are a combination of two antibacterial drugs, which can play a local broad-spectrum, potent, long-lasting antibacterial effect to effectively control and prevent wound infection. OBJECTIVE:To observe the clinical efficacy of silver sulfadiazine water gel dressings on skin defects with wound infection and to explore its biocompatibility. METHODS:Thirty patients with skin defects combined with wound infection were randomized into observation and control groups. Folowing conventional debridement and dressing, the observation group was subject to wound rinse with normal saline, silver sulfadiazine water gel dressings and gauze bandage; in the control group, Vaseline gauze was used folowed by gauze bandage. Visual analog scale scores, dressing adhesion to wound, wound healing rate, and healing time were observed in the two groups at 0, 1, 2 weeks after dressing. RESULTS AND CONCLUSION:The visual analog scale scores in the observation group were significantly lower than those in the control group at 1 and 2 weeks after dressing (P < 0.01), and the wound healing rate was also higher in the observation group than the control group (P < 0.05); wound adhesions were milder in the observation group than the control group when dressing; the healing time was significantly shorter in the observation group than the control group (P < 0.05). These findings suggest that the silver sulfadiazine water gel dressing has good effects on the treatment of skin defects with wound infection, which can reduce pain, effectively control wound infections and promote wound healing.

Chronic Disease ; Elasticity Imaging Techniques ; Humans ; Liver Diseases ; diagnostic imaging

Objective:To study the effects of PLCepsilon siRNA transfection on invasive power of human bladder cancer cell lines T24,and to bring a new method of gene therapy for bladder cancer.Methods:An eukaryotic expression vector containing PLCepsilon siRNA was transfected into T24 and positive cell clones were selected and amplified.Expression of PLCepsilon mRNA was detected by RT-PCR.invasive power of T24 were measured before and after transfection by the membrane invasion culture system(Transwell chamber)and gelatin enzymography(including 72 ku typeIV collagenase and 92 ku typeIVcolagenase analyzed).Results:the result of RT-PCR display that the T24 transfected with pll-PLCepsilon and p12-PLCepsilon vectors had lower expressing of PLCepsilon mRNA than the control groups T24 transfected with HK-A and T24 without transfection.In the membrane invasion culture system the invasion number of T24 transfected with p12-PLCepsilon(26.8?5.8)and the number of T24 transfected with pll-PLCepsilon(25.8?6.2)are both lower than the the control groups T24 transfected with HK-A(33.8?5.7)and T24 without transfection(34.8?6.9)(P

0.05).Conclusions:1.The acute rise in FFAs level for a short term can inhibit ACTH and cortisol secretion in healthy male adults,but with prolonged FFA elevation this inhibition last less than 24 hours.2.The acute FFAs rise has no influence on ACTH or cortisol circadian rhythm.