Objective To explore the relationship of recurrence rate and the age and body temperature of fitrst febrile seizures (FS) in children.Methods One hundred and ninety-two cases of FS admitted to our hospital from Jan 2004 to Jun 2006,were divided into three groups according to the initial onset of body temperature with FS:＞40.0 ℃,～40.0 ℃,≤38.5 ℃ ;three groups according to the duration between fever initiation and seizure attack:≤6 h,～ 12 h,～24 h,＞24 h;four groups according to age:≤6 months,～ 18 months,～ 3 years,＞ 3 years.For each group of children with FS,the recurrence rate and follow-up were compared.Results All cases were followed up to 6 years old,22 cases were lost,and the follow-up rate was 88.5％ (170/192).Follow-up of 170 children with FS,the recurrence rate was 32.6％ (15/46),51.1％ (46/90) and 79.4 ％ (27/34) in each group of temperature ＞ 40.0 ℃,～ 40.0 ℃,and ≤ 38.5 ℃.There were statistically significant among three groups (x2 =17.18,P ＜ 0.05).Duration of fever before seizures ≤ 6 h group,～24 h group,＞ 24 h group,the recurrence rate were 70.7 ％ (29/41),51.6％ (49/95) and 29.4％ (10/34) respectively,the recurrence rate was significant difference among the three groups(x2 =12.71,P ＜0.05).The recurrence rate of different age groups in initial attack of FS were 84.6％ (22/26),63.4％ (45/71),39.5％ (15/38),17.I％ (6/35),the differences were statistically significant (x2 =34.17,P ＜ 0.05).Conclusion There was higher recurrence rate of febrile seizure in small children,lower body temperature and shorter duration between fever initiation and seizure attack.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.

In foreign countries,ascorbic acid (vitamin C) has been used as a complementary drug in cancer treatments for many years.Although it has not been accepted by mainstream medicine,a growing number of in vitro and in vivo experiments indicated that pharmacological concentrations of ascorbic acid could inhibited cancer cell proliferation and promote cell apoptosis.In this paper,the anti-cancer effect of ascorbic acid weer reviewe.d.

Dietary factors play important roles in the initiation and development of breast cancer. There are numerous articles on this topic and most of them focus on the associations between dietary fat, vegetable, fruit, alcohol, phytoestrogen intakes and breast cancer. Different conclusions have been reached.

Glucose-6-phosphate dehydrogenase deficiency is a common monogenic inheritance disorder, with extensive distribution around the world and very high gene frequency. Acute hemolysis may lead to rapidly rising of serum total bilirubin concentrations and may eventually result in bilirubin encephalopathy.The hyperbilirubinemia is the result of abnormal bilirubin metabolism due to complex interactions between G-6-phosphate dehydrogenase deficiency and the genetic co-expression. Neonatal unconjugated hyperbilirubinemia is one of the most common conditions encountered by the practicing pediatricians.

Objective:To study the solubilization effect of 2-hydroxypropyl-?-cyclodextrin(2-HP-?-CD) on anethol trithione and the complexation of anethol trithione with 2-HP-?-CD.Methods:On the basis of single factor experiment,the drug complexed rate was adopted as the index,to study the effects of factors like host-guest molar ratio,alcohol concentration,stiring rate and stiring time on the techniques of preparing anethol trithione-2-HP-?-CD;the inclusion complex was identificated and solubility was detected by diferential scanning calorimeter(DSC) methods.Results:2-HP-?-CD can obviously enhance solubility of anethol trithione.Conclusion:The solubility of inclusion complex increased by 460 times when it was included by 2-HP-?-CD.

Objective To determine which is more effective and safe treatment for controlling febrile seizures in children: Nasal midazolam or intravenous diazepam. Methods Thirty-six children, aged from 6 months to 6 years, with a diagnosis of febrile seizures and seen at Jieyang People's Hospital were in cluded inthis study. Midazolam 0.2～0.3 mg/kg was administered Nasally in 30 seconds by an injector, intravenous di-azepam 0.2～0.3 mg/kg was administered as control group. Results In the Nasal midazolam group, the seizures of 16(16/18) patients terminated in 10 minutes; In the intravenous diazepam group, 15(15/18) pa-tients terminated in 10 minutes, the difference was no statistically significant (P>0.05). the time from pa-tients arrival the hospital to the seizures terminated, the Nasal midazolam group is (209.2±26.1) s;the intra-venous diazepam group is (339.6±42.4) s, and the difference was statistically significant (P<0.05). Con-clusion Nasal midazolam is as effective as intravenous diazepam. However, It is easier to use in nasal drop. it will be very useful for febrile seizures.

Objective To compare the efficacy of continuous midazolam and diazepam infusion for the control of continuous status epileptics (CSE), and to investigate each safe dosage and serious side effect. Meth-otis Forteen children, 0.2 to 12 years of age, with CASE were divided into two groups: in midazolam group (n = 8), seizures uncontrolled after one doses of 0.3 mg/kg of midazolam, continuous midazolam in incremen-tal doses given as a drip infusion was administered; in diazepam group (n = 6), seizures uncontrolled after one doses of 0.3 mg/kg of diasepam, continuous diazepam in incremental doses given as a drip infusion was admin-istered, then comparing the therapeutic effects, and the safe dosages and side effects of midazolam and diazepam were checked. Results Continuous midazolam and diazepam infusions were equally effective for control of re-fractory status epilepticus. There was no significant difference in the proportion of children in two groups with successful control of CSE (P>0.05). However, midazolam was less serious side effect than diazepam. Respira-tory depression was found in one diazepam case. Conclusion Midazolam is effective and safe, and can be used as the first line durg in the treatment of status epilepticus in children.

Objective To study the role of dependence of stromal cell derived factor‐1(SDF‐1) on myocardial infarction an‐giogenesis and function recovery .Methods The rats were randomly divided into the test group (65 cases) and the treatment group (64 cases) ,in which 5 rats in the test group were randomly killed on 1 ,2 ,4 ,7 ,14 ,28 d before and after myocardial infarction(infarc‐tion group) and the SDF‐1 protein level was detected .At the same time the sham operation group(5 cases) was set up;64 rats in the treatment group were randomly divided into four groups ,16 cases in each group ,which were infarction+SDF‐1 group ,infarct+anti‐SDF‐1 group ,infarct+normal saline group and normal+normal saline group .After the corresponding processing in each group ,the SDF‐1 levels after myocardial infarction ,MSCs homing amount ,neovascularization density ,EF and FS levels were compared among various groups .Results The SDF‐1 level after 1-7 d in the infarction group was significantly higher than that in the sham opera‐tion group ,and reached a peak level ,then decreased gradually and restored to normal on 14 d ,the difference was statistically signifi‐cant (P<0 .05) .The MSCs homing amount and neovascularization density level in the SDF‐1 treatment groups were significantly higher than those in other groups ,which in the infarction+anti‐SDF‐1 group were significantly lower than those in the infarction+normal saline group ,the differences were statistically significant (all P<0 .05) .The cardiac function improvement situation in the infarction +SDF‐1 group was significantly better than that in other groups ,the difference was statistically significant (P<0 .05) . Conclusion SDF‐1 can promote angiogenesis in myocardial infarction ,also improve the heart function .

BACKGROUND:Silver sulfadiazine water gel dressings are a combination of two antibacterial drugs, which can play a local broad-spectrum, potent, long-lasting antibacterial effect to effectively control and prevent wound infection. OBJECTIVE:To observe the clinical efficacy of silver sulfadiazine water gel dressings on skin defects with wound infection and to explore its biocompatibility. METHODS:Thirty patients with skin defects combined with wound infection were randomized into observation and control groups. Folowing conventional debridement and dressing, the observation group was subject to wound rinse with normal saline, silver sulfadiazine water gel dressings and gauze bandage; in the control group, Vaseline gauze was used folowed by gauze bandage. Visual analog scale scores, dressing adhesion to wound, wound healing rate, and healing time were observed in the two groups at 0, 1, 2 weeks after dressing. RESULTS AND CONCLUSION:The visual analog scale scores in the observation group were significantly lower than those in the control group at 1 and 2 weeks after dressing (P < 0.01), and the wound healing rate was also higher in the observation group than the control group (P < 0.05); wound adhesions were milder in the observation group than the control group when dressing; the healing time was significantly shorter in the observation group than the control group (P < 0.05). These findings suggest that the silver sulfadiazine water gel dressing has good effects on the treatment of skin defects with wound infection, which can reduce pain, effectively control wound infections and promote wound healing.