Chronic Disease ; Elasticity Imaging Techniques ; Humans ; Liver Diseases ; diagnostic imaging

Objective To determine which is more effective and safe treatment for controlling febrile seizures in children: Nasal midazolam or intravenous diazepam. Methods Thirty-six children, aged from 6 months to 6 years, with a diagnosis of febrile seizures and seen at Jieyang People's Hospital were in cluded inthis study. Midazolam 0.2～0.3 mg/kg was administered Nasally in 30 seconds by an injector, intravenous di-azepam 0.2～0.3 mg/kg was administered as control group. Results In the Nasal midazolam group, the seizures of 16(16/18) patients terminated in 10 minutes; In the intravenous diazepam group, 15(15/18) pa-tients terminated in 10 minutes, the difference was no statistically significant (P>0.05). the time from pa-tients arrival the hospital to the seizures terminated, the Nasal midazolam group is (209.2±26.1) s;the intra-venous diazepam group is (339.6±42.4) s, and the difference was statistically significant (P<0.05). Con-clusion Nasal midazolam is as effective as intravenous diazepam. However, It is easier to use in nasal drop. it will be very useful for febrile seizures.

Objective To compare the efficacy of continuous midazolam and diazepam infusion for the control of continuous status epileptics (CSE), and to investigate each safe dosage and serious side effect. Meth-otis Forteen children, 0.2 to 12 years of age, with CASE were divided into two groups: in midazolam group (n = 8), seizures uncontrolled after one doses of 0.3 mg/kg of midazolam, continuous midazolam in incremen-tal doses given as a drip infusion was administered; in diazepam group (n = 6), seizures uncontrolled after one doses of 0.3 mg/kg of diasepam, continuous diazepam in incremental doses given as a drip infusion was admin-istered, then comparing the therapeutic effects, and the safe dosages and side effects of midazolam and diazepam were checked. Results Continuous midazolam and diazepam infusions were equally effective for control of re-fractory status epilepticus. There was no significant difference in the proportion of children in two groups with successful control of CSE (P>0.05). However, midazolam was less serious side effect than diazepam. Respira-tory depression was found in one diazepam case. Conclusion Midazolam is effective and safe, and can be used as the first line durg in the treatment of status epilepticus in children.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.

In foreign countries,ascorbic acid (vitamin C) has been used as a complementary drug in cancer treatments for many years.Although it has not been accepted by mainstream medicine,a growing number of in vitro and in vivo experiments indicated that pharmacological concentrations of ascorbic acid could inhibited cancer cell proliferation and promote cell apoptosis.In this paper,the anti-cancer effect of ascorbic acid weer reviewe.d.

BACKGROUND: Functional hydrogel Is a new biomaterial, which considered as wound dressing should be generally evaluated according to biological standard to prove the great biocompatibility prior to clinical application.OBJECTIVE: To evaluate the biocompatibility of a new kind of wound dressing, polyvinyl alcohol-gelatin esterified (PGE) hydrogel.DESIGN, TIME AND SETTING: A materials study was performed at Central Laboratory, College of Public Health, University of South China from April 2008 to June 2009.MATERIALS: Fibroblast strain of NCTC L-929 mice was provided by Medical College of Sun Yat-sen University; experimental animals were provided by Animal Faulty of Southern China University; polyvinyl alcohol and gelatin were provided by Chemical Agent Engineering Developing Center, Guangdong.METHODS: A 10-g polyvinyl alcohol was generally dissolved in 100 mL water and the mixture was added with 5 g gelatin at 70 °C. Additionally, hydrochloric acid was added and fully stirred for esterification reaction. The dispersion solution was inserted into the tooting and transformed into membrane-like products which were sectioned into 1-mm round and thin sections. Toxicity test, hemolytic test, and whole-body acute-term toxicity test, and sensitization test of PGE were performed according to national GB/T16886 standard.MAIN OUTCOME MEASURES: Biocompatibility of PGE hydrogel.RESULTS: Toxicity reaction of PGE hydrogel was grade 0-1, and hemolytic ratio was 5%. Following an injection of PGE hydrogel, mice did not have death, convulsion, paralysis, respiratory depression, diarrhea, and decreased body mass. Seventy-two hours later, erythema and edema were not observed on both sides of spine of mice.CONCLUSION: The PGE hydrogel has a good biocompatibility and can be used for wound dressing on clinic.

Dietary factors play important roles in the initiation and development of breast cancer. There are numerous articles on this topic and most of them focus on the associations between dietary fat, vegetable, fruit, alcohol, phytoestrogen intakes and breast cancer. Different conclusions have been reached.

Objective To explore the relationship of recurrence rate and the age and body temperature of fitrst febrile seizures (FS) in children.Methods One hundred and ninety-two cases of FS admitted to our hospital from Jan 2004 to Jun 2006,were divided into three groups according to the initial onset of body temperature with FS:＞40.0 ℃,～40.0 ℃,≤38.5 ℃ ;three groups according to the duration between fever initiation and seizure attack:≤6 h,～ 12 h,～24 h,＞24 h;four groups according to age:≤6 months,～ 18 months,～ 3 years,＞ 3 years.For each group of children with FS,the recurrence rate and follow-up were compared.Results All cases were followed up to 6 years old,22 cases were lost,and the follow-up rate was 88.5％ (170/192).Follow-up of 170 children with FS,the recurrence rate was 32.6％ (15/46),51.1％ (46/90) and 79.4 ％ (27/34) in each group of temperature ＞ 40.0 ℃,～ 40.0 ℃,and ≤ 38.5 ℃.There were statistically significant among three groups (x2 =17.18,P ＜ 0.05).Duration of fever before seizures ≤ 6 h group,～24 h group,＞ 24 h group,the recurrence rate were 70.7 ％ (29/41),51.6％ (49/95) and 29.4％ (10/34) respectively,the recurrence rate was significant difference among the three groups(x2 =12.71,P ＜0.05).The recurrence rate of different age groups in initial attack of FS were 84.6％ (22/26),63.4％ (45/71),39.5％ (15/38),17.I％ (6/35),the differences were statistically significant (x2 =34.17,P ＜ 0.05).Conclusion There was higher recurrence rate of febrile seizure in small children,lower body temperature and shorter duration between fever initiation and seizure attack.

Objective To study the role of dependence of stromal cell derived factor‐1(SDF‐1) on myocardial infarction an‐giogenesis and function recovery .Methods The rats were randomly divided into the test group (65 cases) and the treatment group (64 cases) ,in which 5 rats in the test group were randomly killed on 1 ,2 ,4 ,7 ,14 ,28 d before and after myocardial infarction(infarc‐tion group) and the SDF‐1 protein level was detected .At the same time the sham operation group(5 cases) was set up;64 rats in the treatment group were randomly divided into four groups ,16 cases in each group ,which were infarction+SDF‐1 group ,infarct+anti‐SDF‐1 group ,infarct+normal saline group and normal+normal saline group .After the corresponding processing in each group ,the SDF‐1 levels after myocardial infarction ,MSCs homing amount ,neovascularization density ,EF and FS levels were compared among various groups .Results The SDF‐1 level after 1-7 d in the infarction group was significantly higher than that in the sham opera‐tion group ,and reached a peak level ,then decreased gradually and restored to normal on 14 d ,the difference was statistically signifi‐cant (P<0 .05) .The MSCs homing amount and neovascularization density level in the SDF‐1 treatment groups were significantly higher than those in other groups ,which in the infarction+anti‐SDF‐1 group were significantly lower than those in the infarction+normal saline group ,the differences were statistically significant (all P<0 .05) .The cardiac function improvement situation in the infarction +SDF‐1 group was significantly better than that in other groups ,the difference was statistically significant (P<0 .05) . Conclusion SDF‐1 can promote angiogenesis in myocardial infarction ,also improve the heart function .

This paper introduces the characters and application of the NCBI search toolbar,which is a medical search tool newly presented to the public by the National library of Medicine(NLM) of American.