Chronic Disease ; Elasticity Imaging Techniques ; Humans ; Liver Diseases ; diagnostic imaging

Objective To determine which is more effective and safe treatment for controlling febrile seizures in children: Nasal midazolam or intravenous diazepam. Methods Thirty-six children, aged from 6 months to 6 years, with a diagnosis of febrile seizures and seen at Jieyang People's Hospital were in cluded inthis study. Midazolam 0.2～0.3 mg/kg was administered Nasally in 30 seconds by an injector, intravenous di-azepam 0.2～0.3 mg/kg was administered as control group. Results In the Nasal midazolam group, the seizures of 16(16/18) patients terminated in 10 minutes; In the intravenous diazepam group, 15(15/18) pa-tients terminated in 10 minutes, the difference was no statistically significant (P>0.05). the time from pa-tients arrival the hospital to the seizures terminated, the Nasal midazolam group is (209.2±26.1) s;the intra-venous diazepam group is (339.6±42.4) s, and the difference was statistically significant (P<0.05). Con-clusion Nasal midazolam is as effective as intravenous diazepam. However, It is easier to use in nasal drop. it will be very useful for febrile seizures.

Objective To compare the efficacy of continuous midazolam and diazepam infusion for the control of continuous status epileptics (CSE), and to investigate each safe dosage and serious side effect. Meth-otis Forteen children, 0.2 to 12 years of age, with CASE were divided into two groups: in midazolam group (n = 8), seizures uncontrolled after one doses of 0.3 mg/kg of midazolam, continuous midazolam in incremen-tal doses given as a drip infusion was administered; in diazepam group (n = 6), seizures uncontrolled after one doses of 0.3 mg/kg of diasepam, continuous diazepam in incremental doses given as a drip infusion was admin-istered, then comparing the therapeutic effects, and the safe dosages and side effects of midazolam and diazepam were checked. Results Continuous midazolam and diazepam infusions were equally effective for control of re-fractory status epilepticus. There was no significant difference in the proportion of children in two groups with successful control of CSE (P>0.05). However, midazolam was less serious side effect than diazepam. Respira-tory depression was found in one diazepam case. Conclusion Midazolam is effective and safe, and can be used as the first line durg in the treatment of status epilepticus in children.

BACKGROUND: Functional hydrogel Is a new biomaterial, which considered as wound dressing should be generally evaluated according to biological standard to prove the great biocompatibility prior to clinical application.OBJECTIVE: To evaluate the biocompatibility of a new kind of wound dressing, polyvinyl alcohol-gelatin esterified (PGE) hydrogel.DESIGN, TIME AND SETTING: A materials study was performed at Central Laboratory, College of Public Health, University of South China from April 2008 to June 2009.MATERIALS: Fibroblast strain of NCTC L-929 mice was provided by Medical College of Sun Yat-sen University; experimental animals were provided by Animal Faulty of Southern China University; polyvinyl alcohol and gelatin were provided by Chemical Agent Engineering Developing Center, Guangdong.METHODS: A 10-g polyvinyl alcohol was generally dissolved in 100 mL water and the mixture was added with 5 g gelatin at 70 °C. Additionally, hydrochloric acid was added and fully stirred for esterification reaction. The dispersion solution was inserted into the tooting and transformed into membrane-like products which were sectioned into 1-mm round and thin sections. Toxicity test, hemolytic test, and whole-body acute-term toxicity test, and sensitization test of PGE were performed according to national GB/T16886 standard.MAIN OUTCOME MEASURES: Biocompatibility of PGE hydrogel.RESULTS: Toxicity reaction of PGE hydrogel was grade 0-1, and hemolytic ratio was 5%. Following an injection of PGE hydrogel, mice did not have death, convulsion, paralysis, respiratory depression, diarrhea, and decreased body mass. Seventy-two hours later, erythema and edema were not observed on both sides of spine of mice.CONCLUSION: The PGE hydrogel has a good biocompatibility and can be used for wound dressing on clinic.

Many chemokines and chemokine receptors, such as CCL2 and CXCR4, participate in the growth, angiogenesis, distal metastasis of breast cancer. However, the recent failures in the clinical trials of some single target antagonists suggest that chemokine network in tumor microenvironment is really complicated. Obviously, multi-targets regulation strategy for chemokines is indispensable based on the polypharmacological principle in the future. Atypical chemokine receptors (ACR) as endogenous and physiological regulators, including Duffy antigen receptor for chemokines (DARC), D6 and ChemoCentryx chemokine receptor (CCX-CKR), may be the powerful candidates for this purpose.

Objective:To study the effects of PLCepsilon siRNA transfection on invasive power of human bladder cancer cell lines T24,and to bring a new method of gene therapy for bladder cancer.Methods:An eukaryotic expression vector containing PLCepsilon siRNA was transfected into T24 and positive cell clones were selected and amplified.Expression of PLCepsilon mRNA was detected by RT-PCR.invasive power of T24 were measured before and after transfection by the membrane invasion culture system(Transwell chamber)and gelatin enzymography(including 72 ku typeIV collagenase and 92 ku typeIVcolagenase analyzed).Results:the result of RT-PCR display that the T24 transfected with pll-PLCepsilon and p12-PLCepsilon vectors had lower expressing of PLCepsilon mRNA than the control groups T24 transfected with HK-A and T24 without transfection.In the membrane invasion culture system the invasion number of T24 transfected with p12-PLCepsilon(26.8?5.8)and the number of T24 transfected with pll-PLCepsilon(25.8?6.2)are both lower than the the control groups T24 transfected with HK-A(33.8?5.7)and T24 without transfection(34.8?6.9)(P

Objective To explore the relationship of recurrence rate and the age and body temperature of fitrst febrile seizures (FS) in children.Methods One hundred and ninety-two cases of FS admitted to our hospital from Jan 2004 to Jun 2006,were divided into three groups according to the initial onset of body temperature with FS:＞40.0 ℃,～40.0 ℃,≤38.5 ℃ ;three groups according to the duration between fever initiation and seizure attack:≤6 h,～ 12 h,～24 h,＞24 h;four groups according to age:≤6 months,～ 18 months,～ 3 years,＞ 3 years.For each group of children with FS,the recurrence rate and follow-up were compared.Results All cases were followed up to 6 years old,22 cases were lost,and the follow-up rate was 88.5％ (170/192).Follow-up of 170 children with FS,the recurrence rate was 32.6％ (15/46),51.1％ (46/90) and 79.4 ％ (27/34) in each group of temperature ＞ 40.0 ℃,～ 40.0 ℃,and ≤ 38.5 ℃.There were statistically significant among three groups (x2 =17.18,P ＜ 0.05).Duration of fever before seizures ≤ 6 h group,～24 h group,＞ 24 h group,the recurrence rate were 70.7 ％ (29/41),51.6％ (49/95) and 29.4％ (10/34) respectively,the recurrence rate was significant difference among the three groups(x2 =12.71,P ＜0.05).The recurrence rate of different age groups in initial attack of FS were 84.6％ (22/26),63.4％ (45/71),39.5％ (15/38),17.I％ (6/35),the differences were statistically significant (x2 =34.17,P ＜ 0.05).Conclusion There was higher recurrence rate of febrile seizure in small children,lower body temperature and shorter duration between fever initiation and seizure attack.

Dietary factors play important roles in the initiation and development of breast cancer. There are numerous articles on this topic and most of them focus on the associations between dietary fat, vegetable, fruit, alcohol, phytoestrogen intakes and breast cancer. Different conclusions have been reached.

Glucose-6-phosphate dehydrogenase deficiency is a common monogenic inheritance disorder, with extensive distribution around the world and very high gene frequency. Acute hemolysis may lead to rapidly rising of serum total bilirubin concentrations and may eventually result in bilirubin encephalopathy.The hyperbilirubinemia is the result of abnormal bilirubin metabolism due to complex interactions between G-6-phosphate dehydrogenase deficiency and the genetic co-expression. Neonatal unconjugated hyperbilirubinemia is one of the most common conditions encountered by the practicing pediatricians.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.