The study involved 13 patients (8 males, 5 females) who aged 15-41 years of old and hospitalized at the National Institute for Burn. Burn-caused agents were heat and chemicals (fire, boiling water and lime). Burn area was from 4% to 30% of body area. The patients were applied the drug within 48 hours after burning. There was not difference between effect of maduxin ointment-available gauze and self-prepared maduxin ointment gauze on clinical and in laboratory findings. The maduxin ointment-available gauze is easy and convenient in use and conservation. The cost-effective of this gauze is similar to the ointment packaged in container and tube, but it help save the time for bandage changing.
burns ; Ointments

Maduxin ointment is extracted from the leaves and seeds of the Madhuca pasquieri H.J. Lam, Sapotaceae family and has been applied in burn treatment in Vietnam since 1987. We studied the effects of Maduxin at slaked lime burn wounds - a frequent type of burn in Viet nam - in comparison with effect of silversulfadiazine in burn treatment. Our study was carried out on 94 slaked lime burn patients who were treated at the Viet nam National Institute of Burn from Nov. 1994 to Oct. 1997. The results showed that Maduxin ointment transferred wet eschar to dry eschar, shortened the treatment of III- leveled burn to 17,8 days from 19,5 days in the control group. After 2 weeks of treatment, Maduxin limited the appearance of P.aeruginosa and S. aureus, reduced the number of microbacteria in the surface of the wounds to the similar number of that in the control group. The number of fibrocytes, fibroblasts in the burn wounds treated with Maduxin ointment increased significantly after 14 days and the mucopolysaccharide was created after 7- 15 days at a higher level than that in the control group.
ointments ; burns

The ointment SH-91 is used in the burn treatment with anti-infection, anti-inflammatory, clean of burn area. It is also used in local treatment of peeled thin and light thick skins. 78 patients with burn in National Institute of Burn from February 1997 to May 1998 participated to the study in comparison with vasaline. The smallest area of peeled skin is 1% body area and largest area is 10% body area. Results: The ointment SH-91 has had effects of analgesia, anti-inflammatory, reduced fluid excretion, limited secondary bleeding, rapid recover of injury, easy to use and is not necessary to distribute the bandage.
ointments, burns

Moist exposed burn therapy is a therapeutic principle based on the moist environment of the wound, using an ointment of herbal origin that enhances epithelial repair. This is the case of a 42-year-old female who sustained partial thickness burn wounds on her face and upper extremities. Patient was started on wound dressing with 13-sitosterol and berberine moist exposed burn ointment (MEBO) and noted the formation of erythematous verrucous plaques overlying the burned areas after four weeks. Histopathological examination of the lesions revealed papillomatosis, acanthosis, and hyperkeratosis. The lesions resolved upon discontinuation of MEBO and application of a combination of topical steroid, keratolytic, and emollient. The reactive epidermal hyperplasia seen in the case presented may have been due to increased levels of basic fibroblast growth factor in burn wounds treated with MEBO. Careful instructions and close monitoring of patients applying the ointment must be reinforced due to the possibility of reactive inflammatory skin reactions.

Human ; Female ; Middle Aged ; Bandages ; Berberine ; Burns ; Emollients ; Fibroblast Growth Factor 2 ; Hyperplasia ; Ointments ; Sitosterols ; Wound Healing

PURPOSEEphedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing.

METHODSAn aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis.

RESULTSPhytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers.

CONCLUSIONE. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically.

Animals ; Burns ; drug therapy ; Disease Models, Animal ; Ephedra ; chemistry ; Male ; Mesocricetus ; Ointments ; Plant Extracts ; analysis ; therapeutic use ; Wound Healing ; drug effects

OBJECTIVETo evaluate the therapeutic effect of silver nitrate ointment on partial-thickness burn wounds, and observe its side-effects.

METHODSMulti-center, randomized, positive drug paralleled self-controlled trial was carried out. Eighty patients with superficial partial-thickness burns, and 40 with deep-partial thickness burns were randomized into AgNO3 group and SD-Ag group according to drug topically applied to the wounds. The wound healing time, wound healing rate and bacterial culture of the wound, the effect and safety of the drug, as well as drug irritation to the wounds were studied in these two groups.

RESULTSFor the patients with superficial partial-thickness burn wounds, the wound healing time in silver nitrate group was (9.5 +/- 2.7) days, which was obviously shorter than that in SD-Ag group [(10.8 +/- 3.4) days, P <0.01]. The wound healing rate in silver nitrate group on 7 post-burn day ( PBD) was (77.9 +/- 20.5)%, which was obviously higher than that in SD-Ag group [(67.3 +/- 22.6) %, P < 0.01]. For those with deep-partial thickness burn wounds, the wound healing time in silver nitrate group was (21.5 +/- 4.8) days, which was evidently shorter than that in SD-Ag group [(23.3 +/- 6.4) days, P <0.01]. The wound healing rate in silver nitrate group on 20 PBD was (86.6 +/- 15.9)%, which was evidently higher than that in SD-Ag group [(78.5 +/- 17.7)%, P < 0.01]. Silver nitrate ointment has the same antibacterial effect as 1% SD-Ag cream, but it was less painful when applied to the open wounds.

CONCLUSIONSilver nitrate ointment is an effective and safe medicament for the clinical management of partial-thickness burn wounds.

Adolescent ; Adult ; Anti-Infective Agents, Local ; therapeutic use ; Burns ; drug therapy ; pathology ; Female ; Humans ; Male ; Middle Aged ; Ointments ; Silver Nitrate ; therapeutic use ; Silver Sulfadiazine ; therapeutic use ; Wound Healing