The chronic B-cell antigen receptor (BCR) pathway plays an important role in malignant proliferation of B-cell lymphoma.Several tyrosine kinase inhibitors have shown impressive anti-tumor activity in relapsed and refractory B-cell non-Hodgkin lymphoma.This review discussed essential tyrosine kinases in BCR signaling pathway and present data from clinical usage of these related novel target agents.

Lung cancer-related papers published by authors of China were retrieved from PubMed and the high frequency subject headings and subheadings were extracted from them using the Bicomb system.The status quo and hot spots of lung cancer-related studies in China were analyzed .

Objective To evaluate 3 female sexually transmitted diseases(STD).Methods 799 cases of female STD were tested by means of polyerase chain reaction(PCR) we analyzed the incidence age,types,diagnosis and treatment.Results The peak incidence was ranged from 25 to 30 years.The highest incidence was non-gonococcal cervicitis (urethritis),cervicitis type was frequently,often infertility.The treatment of condyloma acuminata key was removal of warts by laser and antiviral therapy.Mucopus and urinary irritation symptoms were the clinical features of gonrrhea.Mixed infections were common,needs to use antimicrobial agents which were effective to four pathogens.Conclusion The risk of non-gonococcal cervicitis(urethritis) is increasing,it could infect cervix,induce to infertility.It is necessary to increase the search,prevention and treatment for the STD.

Advances in clinical transformation research has facilitated discovery of a number of novel somatic mutations and aberrant intracellular signaling pathways involved in malignant proliferative B-cell lymphoma.Meanwhile,small molecular inhibitors targeting those mutation genes or signaling pathways have also been shown to be effective in treating relapsed and refractory B-cell non-Hodgkin lymphoma.This paper reviewed important discoveries in clinical transformation research in lymphoma field in 2013.

Objective:To identify the expression of egfp-hri fusion on NIH3T3 cells which is carried by recombinant retrovirus. Methods:The egfp-hri fusion gene was integrated intoNIH3T3 cells by the infection of recombinant viral supernatant from the G418 resistent PA317 cells transfected stably with the plasmid of pLNCX-EGFP-C1-hri. The expression effect of egfp-hri fusion was visualized under the fluorescent microscope, while the expression levels of egfp-hri fusion protein by Western blot. Results:The observation from fluorescent microscope showed the green fluorescent was obviously observed in the cytoplasm , western-blotting showed the expression level of egfp-hri fusion gene increased by 83%and 81%, as compared with those uninfected cells and in the cells infected with empty vector, respectively. Conclusion:The infected NIH3T3 cells can express egfp-hri fusion protein successfully.

A total of 122 patients with acute left ventricular failure from January 2011 to December 2013 at our hospital were recruited and divided randomly into control group (n =62) and observation group (n =60).Control group received conventional therapy and Bi-level positive airway pressure (Bi-PAP) was added along with conventional therapy for observation group.And 12 and 8 patients died in control and observation groups respectively within 24 h after treatment and there was no statistical difference.The BNP levels of the control group pre-treatment and at 1 h and 24 h post-treatment were (1 040 ± 315),(995 ± 245) and (570 ± 164) ng/L.The BNP levels of observation group pre-treatment and at 1 h and 24 h posttreatment were (1 080 ±209),(995 ±245) and (490 ± 138) ng/L.BNP of observation group at 1 h and 24 h post-treatment decreased significantly compared with that pre-treatment and control group (P ＜0.01).Only at 24 h post-treatment,the BNP level of control group decreased significantly compared with that pretreatment (P ＜ 0.01).

Cataract and age-related macular degeneration (AMD) often present concurrently in aged persons. There has been a longstanding controversy among clinicians as to whether cataract surgery is contraindicated in eyes with AMD. Most of previous researches indicated that cataract surgery could accelerate the progression of AMD. However recently studies suggested that cataract surgery improved visual function of the patients and didn't accelerate the progression of AMD. These are related to the development of cataract surgery and the using of phacoemulsification technique.

Through tracing to the source of syndrome differentiation according to meridian and collateral theory, Lingshu: Jingmai (Miraculous Pivot * Meridians) is studied in this article. Considered the requirement and concept of treatment according to syndrome differentiation, the application of proper syndrome differentiation methods based on meridian and collateral theory in acupuncture clinic is discussed. Theories, key factors as well as historical relations of syndrome differentiation according to meridian and collateral are also analyzed. The feature and origin of syndrome differentiation according to meridian and collateral, which are considered to be more important, are also discussed. Focuses of explanation are put on the functions, significances, connotations, relationship and clinical application of two major factors of syndrome differentiation, namely the running course of meridian and collateral and signs.
Acupuncture Therapy ; Diagnosis, Differential ; Humans ; Meridians ; Syndrome

Objective:To investigate the efficacy of Zhongjiefeng dispersible tablets combined with ranitidine in the treatment of recurrent oral ulcer and its effec on inflammatory factors. Methods:Eighty-six patients who received recurrent oral ulcer in Yiwu Hospital of Traditional Chinese Medicine from January 2019 to January 2020 were included in this study. They were randomly assigned to receive treatment with either ranitidine (control group, n = 43) or Zhongjiefeng dispersible tablets combined with ranitidine (observation group, n = 43) for 4 weeks. Before and after treatment, visual analogue scale score and inflammatory factor were compared between the control and observation groups. Change in main symptom score after treatment relative to before treatment and the curative effect were also compared between the two groups. Results:After treatment, the visual analogue scale score in the observation group was significantly lower than that in the control group [(1.32 ± 0.37) vs. (3.06 ± 0.54), t = 17.430, P < 0.05]. After treatment, serum interleukin-2 [(16.42 ± 3.18) μg/L], interleukin-6 [(6.56 ± 1.28) ng/L], tumor necrosis factor-α [(7.69 ± 1.34) μg/L] levels in the observation group were significantly lower than those in the control group [(25.97 ± 5.24) μg/L, (9.84 ± 1.62) ng/L and (11.86 ± 1.83) μg/L, t = 10.217, 10.4617 and 12.056, all P < 0.05]. After treatment, ulcer area score [(0.76 ± 0.14) points] and ulcer number score [(0.68 ± 0.19) points] in the observation group were significantly lower than those in the control group [(1.21 ± 0.20) points and (1.24 ± 0.30) points, t = 12.087, 10.341, both P < 0.05]. Total effective rate in the observation group was significantly higher than that in the control group [93.02% (40/43) vs. 72.09% (31/43), χ 2 = 6.541, P < 0.05]. Conclusion:Zhongjiefeng dispersible tablets combined with ranitidine exhibits obvious curative effect on recurrent oral ulcer in patients through reducing pain and inflammatory reaction.

Objective: To study the therapeutic effect of intra-arterial infusion of thrombolytic agents for patients with sudden sensorineural hearing loss. Methods: 41 patients were assigned to two groups. In the intra-arterial infusion group, 19 cases were infused 300 000 unit Urokinase via vertebral artery within 30 minutes. In control group, 22 patients were treated intravenously. The criterion of therapeutic effect formulated by Chinese Association of Otorhinolaryngology in 1997 was used to evaluate the therapeutic effect. Results: In the intra-arterial group, 9 of 19 were healed completely. Improvement of hearing loss were observed in 8 cases, among them, 5 showed marked improvement. No improvement in 2 patients. In the control group, 4 patients recovered. 11 improved, 2 of then showed marked improvement. No improvement in 7. Conclusion: Intra-arterially regional infusion of thrombolytic agents may become a new and effective treatment for the patients with sudden sensorineural hearing loss.