Vitamin D is a steroid hormone that exerts its action by binding to the vitamin D receptor.In addition to its actions on calcium and phosphate metabolism,it exhibits a plethora of regulatory effects on proliferation,dfferentation and function of the cells of the immune system,thus play an important role in the regulation of the immune response.Systemic lupus erythematosus (SLE) is a multisystemic auto-Immune disease that is characterized by a number of autoantibodies.VitD and VDR can inhibit the activation of autoreactive lymphocyte and the production of auto-antibodies,thus play an important role in the development and mechanism of SLE.Supplementation of VitD may improve the progrosis of SLE.

Objective To study the surgical effect of sylvian lateral fissure approach in the treatment of patients with hypertensive intracerebral hemorrhage on basal ganglia.Methods Sixty-two patients with hypertensive intracerebral hemorrhage on basal ganglia in our hospital from October 2012 to June 2015 were selected,and equally divided into control group and observation group.The control group was treated with temporal cortex approach surgery,and the observation group was treated with sylvian lateral fissure approach surgery.The hematoma clearance rates of different amount of bleeding,and nerve function indexes and ADL score before the treatment and at different time after the treatment of two groups were compared.Results The hematoma clearance rates of observation group with different amount of bleeding were higher than those of control group.The serum nerve function indexes were lower than those of control group.The ADL scores were better than those of control group.The above differences were statistically significant (P＜0.05).Conclusion The clinical effect of sylvian lateral fissure approach in the treatment of patients with hypertensive intracerebral hemorrhage on basal ganglia is better.The approach has an active role in the improvement of the hematoma clearance and nerve function and greater value for the patients with hypertensive intracerebral hemorrhage on basal ganglia.

Objective:To investigate the effects of adramycin on cell line of FRH-0201.Methods:Human hilar cholangiocarcinona cell line were cultured with adramycin (2?g/ml) through lasting different times,finally this cell line can survive after 72h cultured in the culture liquid with the adramycin(1?g/ml) .Then the medium was replaced with a fresh one without adramycin,and the cells were continuously cultured for 1 month.The in vitro studies included the observation of the appearance with optical microscope,MTT cell proliferation assay,analysis of the cell cycle by Flow cytometry(FACS),assays of tumor marker using en{yme-linked immunosor bent assay(ELISA),the fluorescence density of adramycin.Results:Compared to the parent FRH-0201cell line:The morphology showed typical morphological characteristics,the doubling time prolonged about 3h,the cell cycle by flow cytometry identified in G_1,G_2 and S phase of cell cycle were 40.50%,19.74%and 39.77% in trial group,and 69.83%,7.29%and 22.88% in parent group,respectively.Tumor marker has no difference between them,the fluorescence density of epirubicin descending 5.2 times.Conclusion:The adramycin can affect the cell cycle and cause the change of metabolism.

Objective To investigate the assessment value of serum Lp-PLA2 ,hs-CRP and D-D dimer on the severity of cor-onary artery lesion .Methods A total of 136 patients with coronary heart disease acute myocardial infarction (AMI) group 46 ca-ses ,stable angina pectoris (SAP) group 38 cases and unstable angina pectoris (UAP) group 52 cases from the inpatient of cardiolo-gy department in our hospital were selected as observation group ,and 135 healthy subjects were selected as control group ,serum Lp-PLA2 was detected by enzyme kinetic method ,Serum hs-CRP and plasma D-D dimer were detected by immune turbidimetric method ,of the severity of coronary artery lesion was evaluated by the Gensini integrations .Results Serum Lp-PLA2 ,hs-CRP ,D-D dimer level and Gensini score of observation group were significantly higher than those of control group ,above indexes of AMI group were higher than those of SAP group and UAP group ,UAP group were significantly higher than SAP group ,with statistical significance between the two groups(P<0 .05) .Serum Lp-PLA2 ,hs-CRP ,D-D dimer level and Gensini score of patients with heart functional class Ⅱwere significantly lower than those of Ⅲ and Ⅳ patients ,above indexes of patients with heart functional class Ⅲwere significantly lower than Ⅳ patients ,the difference between two groups was significant(P<0 .05) .Compared with severity of coronary artery lesion ,serum Lp-PLA2 hs-CRP and D-D dimer levels of mild coronary artery lesions were significantly lower than those of moderate and high coronary artery lesions ,and moderate coronary artery lesions was obviously lower than high coronary artery lesions (P<0 .05) ,Pearson correlation analysis also found that ,Lp-PLA2 ,hs-CRP ,D-D dimer levels had positive correlation with Gensini score (r=0 .642 ,0 .651 ,0 .608 ,P<0 .05) .Conclusion The assessment of serum Lp-PLA2 ,hs-CRP and D-D dimer level in the severity of coronary artery lesion has important significance .

The article points out that to improve the teaching quality and level of national medical colleges and universities,the experience of Medical College of Monpillier University,France should be introduced and learned from.Views and suggestions are also put forward to counter the existing problem in national medical teaching system and clinical practices.

Objective To discuss the therapeutic efficacy of budesonide and compound ipratropium bromide inhalated in treatment of infant bronchiolitis.Methods From January 2005 to February 2007,150 infants with bronchiolitis were randomly divided into treated group and control group.Both the two groups were treated with comprehensive treatment and antiviral therapy;control group were treated with budesonide suspemion and compound ipratropium bromide inhalated.Clinical efficacy of both two groups was evaluated.Results Cure rate of treatment group was 91%,cure rate of control group was 71%,the clinical therapeutic efficacy were compared between the two groups,the difference of which had statistical significance.Conclusion The result of experiment indicates that the therapeutic efficacy of budesonide and compound ipratropium bromide inhalated in treatment of infant bronchiolitis is better method.

Objective:To develop an HPLC method for the simultaneous determination of oleanic acid and ursolic acid in Salvia plebeia R. Br. from different origins. Methods:The column was Agilent-C18 (250 mm × 4. 6 mm,5μm) with the temperature of 25℃, the mobile phase was methanol-water-glacial acetic acid-triethylamine (90 ∶10 ∶0. 03∶0. 06) at the flow rate of 1. 0 ml·min-1 ,and the detection wavelength was 210 nm. Results: The calibration curves were linear within the range of 7. 50-75. 00 μg · ml-1 for oleanic acid(r=0. 999 7)and 5. 00-50. 00 μg · ml-1 for ursolic acid(r=0. 999 7). The average recovery of oleanic acid and ursolic acid was 100. 15%(RSD=1. 14%,n=6)and 99. 40%(RSD=1. 67%,n=6), respectively. Conclusion: The method is simple and accurate, which is suitable for the determination of oleanic acid and ursolic acid in Salvia plebeia R. Br. from different origins.

Professor LI De-lin is sophisticated in the clinical experiences of treating diabetes mellitus(DM)with traditional Chinese medicine(TCM).Based on clinical observations for many years,the key pathogenesis of DM resulted from internal organs'deficiency,endogenous heat exuberance,liquid and qi's consumption as well as blood density and turbid fluid thickness.From the knowledge above,professor LI advocated to treat DM and diseases accompanied by it with the combination of treatment based on disease and syndrome differentiation to improve the curative effects.During the specific treatments,professor LI emphasized that treatment based on disease differentiation should benefit qi,nourish yin and strengthen yang;treatment based on syndrome differentiation should strengthen vital qi and eliminate pathogenic factor.Strengthening vital qi includes to benefit qi ,nourish blood,tonify yang and supply yin.Eliminating pathogen includes to treat heat-toxicity,phlegm,dampness and depression at the same time.He advocated firstly to invigorate spleen and kidney,secondly to clear heat fire and disperse stagnated liver qi,lastly to moisten and invigorate lung.We received satisfactory curative effects both on the clinical treatments and experiments in DM and diseases accompanied by it when adopting the TCM methods of treatment based on the theory by Professor LI De-lin.

Objective To study the effects of the accessory deep peroneal nerve,an anomalous branch of the superficial peroneal nerve, on the diagnosis of the deep peroneal nerve injuries. Methods Ten cases (7 male, 3 female, mean age 32.8 years) of deep peroneal nerve injuries with the presence of accessory deep peroneal nerve were examined in this study. All the cases were reviewed and analyzed with regard to the basic anatomy, clinical symptoms, electrophysiological data and diagnosis. Results In the presence of the accessory deep peroneal nerve, the lesions of the deep peroneal nerve spare the function of the lateral portion or the whole of the the extensor digitorum brevis (EDB) muscle. It may result in an unconformity of the severity of lesion and its clinical symptoms as well as the electrophysiological findings. Conclusion Knowledge of this anomaly is of crucial importance in the clinical evaluation of nerve injuries of deep peroneal nerve, as well as in avoiding errors in interpreting the electrophysiological data of this nerve.

Objective To study the effect of the Riche-Cannieu anastomosis, an anomalous anastomosis between the deep branch of ulnar nerve and the recurrent branch of median nerve in the palm of the hand, on the diagnosis of patients with carpal tunnel syndrome. Methods Twelve patients (2 male, 10 female, mean age 49.8 years) with carpal tunnel syndrome with the presence of Riche-Cannieu anastomosis were tested in this study. Their clinical data including the symptoms and signs, electrophysiological findings and diagnosis were collected and discussed in relation to an anatomical review of these nerves. Results Due to the existence of the Riche-Cannieu anastomosis, the patients with carpal tunnel syndrome spared part or all of the function of the abductor pollicis brevis (APB) muscle. It may result in an unconformity of the patients′lesion degree caused by carpal tunnel syndrome and its clinical symptoms and electrophysiological findings. Conclusion Knowledge of the Riche-Cannieu anastomosis is of crucial importance in the clinical evaluation, diagnosis and treatment of carpal tunnel syndrome, as well as in avoiding errors in interpreting the electrophysiological data of the patients.