Adult ; Ascorbic Acid ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; therapeutic use ; Female ; Humans ; Infusions, Intravenous ; Male ; Myocarditis ; drug therapy ; virology ; Phytotherapy ; Virus Diseases ; drug therapy

Objective To evaluate the long term efficacy of partial splenic embolization(PSE) for thalassanemia major. Methods 75 patients with thalassanemia major were treated with PSE and followed for 5 years,in which 30 patients with compelete data were studied.There were 8 patients with ? thalassanemia major,22 patients with ? thalassanemia major.The follow up indices included mean haemoglobin concertration,transfusion indices and blood transfusion consumption after embolization at 1,2,3,4,5 years. Results 26 of 30 patients showed a reduction in blood transfusion requirements and increase in haemoglobin level after embolization. The median blood transfusion requirements decreased from 1 200 ml/year before embolization to 200 ml/year; and the transfusion indices dropped from 6 times/year to 1 time/year. The mean of haemoglobin level increased from (60 9? 18 9)g/L to (82 3?17 4)g/L. The total effective rate was 86 7%,in which ? ,? thalassanemia major were 100 0%,81 8% respectively. Conclusion PSE is an effective therapeutic procedure for thalassanemia major, especially for ? thalassanemia major.

Animals ; Autoantigens ; genetics ; metabolism ; physiology ; Centromere Protein A ; Chromosomal Instability ; Chromosomal Proteins, Non-Histone ; genetics ; metabolism ; physiology ; Gene Expression Regulation, Neoplastic ; Humans ; Kinetochores ; metabolism ; Mitosis ; physiology ; Rectal Neoplasms ; genetics ; metabolism ; pathology ; Spindle Apparatus ; metabolism

Adolescent ; Asthma ; blood ; drug therapy ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Interleukin-17 ; blood ; Male

Objective: To investigate the diterpenoid alkaloids from Aconitum episcopale. Methods: The obtained compounds were isolated by different chromatographic methods and their structures were identified by physicochemical properties and spectral data. Results: Ten diterpenoid alkaloids were isolated and identified as talatizamine (1), chasmanine (2), crassicauline A (3), foresaconitine (4), acoforestinine (5), yunaconitine (6), 3-deoxy-8-deacetyl-yunaeonitin (7), leucanthumsine D (8), pengshenine B (9), and macrorhynine B (10). Conclusion: Compounds 2-5 and 7-10 are isolated from this plant for the first time.

OBJECTIVE: To observe the toxicity effect of realgar on rat fertility and early embryo development. METHODS: Male and female SD rats were divided into control group, realgar low (50 mg · kg-1), medium (125 mg · kg-1) and high (250 mg · kg-1) dose groups. Realgar (batch No. H2007052401) was given by i.g. daily to male rats from six weeks before mating until the successful mating day and to females from two weeks before mating until the sixth day of pregnancy. Male rats were sacrificed after mating, and female rats were sacrificed on the 15th day of pregnancy. The numbers of corpus luteum, implantation spot, and survival fetus were recorded. Histopathological examination was carried out. Statistical analysis was done to compare with the control group. RESULTS: The mating rates, pregnancy rates, live fetus rates, loss rates before and after implantation, the number of corpus luteum, the number of implantations and reproductive organs in realgar groups were not significantly different when compared with the control group. Histopathological examination showed that there were micro-vacuolization in liver cells, focal infiltration of mononuclear cells and steatosis in liver in some female rats (3/10) and male rats (1/10) in realgar high-dose groups. And some female rats (2/10) in realgar high-dose group had interstitial fibroblasts proliferation with lymphocyte infiltration and focal renal tubular basophilic change. CONCLUSION: Realgar has no significant toxicity effect on rat fertility and early embryo development, but has certain toxicity to liver and kidney.

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Adult ; Coronary Disease ; therapy ; Female ; Humans ; Male ; Middle Aged

Objective To investigate the new method of ureter bladder anastomosis in renal transplantation.Methods The ureter was pulled into bladder for 1.2 cm through tunnel at the lateral- top of bladder wall,and the ureter fixed on the bladder wall by 2-3 acus with catgut suture.Results Forty of 42 patients had no complications,and recovered very well,except for 1 cases of necrosis caused by acute rejection and 1 case on urine leakage caused by catheter obstruction from blood clot.Conclu- sion This method is simple,easy to operate,safe and reliable with less complications.

Objective To evaluate the changes of immunologic function in children with thalassanemia major after partial splenic embolization(PSE).Methods Immunoglobulins,T cell subsets were detected by immunologic turbidimetry and APAAP with monoclonal antibody respectively in 40 children with thalassanemia major and also in 20 healthy persons before and after PSE.These immunologic indexes were compared before and after PSE.Results The levels of IgG in serum were significantly lower one week after PSE than that before PSE.It turned to normal three weeks after PSE.The IgM,IgA levels remained unchanged during PSE.The levels of CD_3、CD_4、CD_4/CD_8 ratio in children with thalassanemia major were decreased(P

OBJECTIVE:To study the bio-equivalence of domestic loratadine syrup and tablets in human beings.METHODS:a dose fo40mg domestic loratadine(syrup or tablet)was given to18healthy male volunteers to a randomized crossover design.Blood samples were collected before administration and20min,40min,1hr,1.5hr,2hr,3hr,4hr,6hr,8hr,12hr,24h after administration.The concentrations of Loratadine in blood were determined by HPLC.Pharmacokinetic parameters and relative bio-availability were detected with3p97program.RESULTS:The main pharmacokinetic parameters of domestic Lortadine syrup and tablet were as follows:C max were(40.91?15.42)ng/ml and(41.57?18.68)ng/ml respectively;T max were(1.04?0.19)h and(1.19?0.25)h respectively;T 1/2 were(4.43?1.67)h and(4.21?1.49)h respectively;AUC 0～24 we_ re(127.60?46.28)(ng?h)/ml and(133.13?45.65)(ng?h)/ml respectively;AUC 0～∞ were(132.98?47.43)(ng?h)/ml and(138.16?47.26)(ng?h)/ml respectively.The relative bio-availability was(96.25?21.30)%.CONCLUSION:the do?mestic Lortadine syrup and tablet are bio-equivalent.