No abstract available.
Malaria, Cerebral* ; Plasmodium falciparum*

Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection. Cerebral malaria can lead to cerebral infarction by several mechanisms including systemic inflammatory response. The systemic inflammatory response is known to rarely occur in Plasmodium vivax infection. We report a patient who developed multiple cerebral infarctions following Plasmodium vivax infection.
Cerebral Infarction ; Humans ; Malaria, Cerebral ; Plasmodium ; Plasmodium falciparum ; Plasmodium vivax

Mixed falciparum-vivax infection accounts for 5% of all malaria cases seen in endemic region. However, a larger proportion of mixed malaria cases develop cerebral complication. We report one case of mixed infection resulted in cerebral malaria.
Coinfection ; Malaria* ; Malaria, Cerebral

Malaria is a worldwide febrile illness with high morbidity and mortality. High fever, jaundice, hemolysis, and hepatosplenomegaly are usual symptoms and signs of malaria, whereas retinal hemorrhage is an unusual finding. Retinal hemorrhage has been known to be one of the clinical manifestations in severe Plasmodium falciparum infection, especially in children developing cerebral malaria. However, retinal hemorrhage can occur in adult patients with severe parasitemia, shizontemia, anemia and may occur in malaria infections caused by other Plasmodium species, because it is due to dense parasitemia in deep vascular beds. A case of Plasmodium vivax malaria with retinal hemorrhage has not been reported as yet. We report a Plasmodium vivax malaria patient with retinal hemorrhage, who presented with severe schizontemia and anemia.
Adult* ; Anemia ; Child ; Fever ; Hemolysis ; Humans ; Jaundice ; Malaria ; Malaria, Cerebral ; Malaria, Vivax* ; Mortality ; Parasitemia ; Plasmodium ; Plasmodium falciparum ; Plasmodium vivax ; Retinal Hemorrhage* ; Retinaldehyde*

Blackwater fever is a serious clinical syndrome manifested by acute intravascular hemolysis, fever, and the passage of black or red urine, which is classically associated with falciparum malaria and irregular administration of quinine. In Korea, Plasmodium vivax is the only endemic malaria circulating; a number of imported cases of falciparum malaria have been reported in patients following return from international travel to a malaria endemic area. Therefore, it is important for health care professionals including pediatricians to be aware of the falciparum malaria and its clinical courses. Herein, we report a case of a 14-year-old girl with severe falciparum malaria that was complicated by blackwater fever.
Adolescent ; Blackwater Fever* ; Child* ; Delivery of Health Care ; Female ; Fever ; Hemolysis ; Humans ; Korea ; Malaria* ; Malaria, Falciparum ; Plasmodium vivax ; Quinine

A total of 10.140 Anopheles mosquitoes were collected during the period 1985-1995 in 5 study sites. ELISA(+) reactions were detected in 229 mosquito samples from 10 Anopheles species of An.minimus, An.dirus, An.vagns, An.maculatus, An.subpictus, An.campestris, An.tessellatus, An.jeyporiensis, An.aconitus, An.spl. In Bai Tranh (Thanh Hoa province), Khanh Phu and Khanh Nam (Khanh Hoa province), 7 species were found to be infected with malaria sporozoites as An.minimus, An.dirus, An.vagus, An.maculatus. An.aconitus, An.tessellatus, An.jeyporiensis. In the brackish water commune Phong Phu (Binh Chanh district, HCM city) and in Can Giuoc district (Long An province), 7 species were found to be infected with malaria sporozoites as An. subpictus, An.sinensis, An.sundaicus, An.campestris, An.vagus, An.tessellatuss, An.spl. The positive infection rate was An.dirus (4,5% - 8,5%), An.minimus (8,3%) in Khanh Phu and Khanh Nam (Khánh Hòa) and An.sinensis (4,5% - 11%). An.campestris (6,6% - 6,7%), An.vagus (4,6%) in Phong Phu (HCM city) and Can Giuoc (Long An)
malaria ; diagnosis ; malaria, falciparum ; mosquitoes ; Sporozoites ; Enzyme-Linked Immunosorbent Assay ; malaria ; malaria, falciparum ; mosquitoes ; Sporozoites ; malaria, vivax

Malaria is one of the most important parasitic infection in the world. Four species of the genus Plasmodium cause nearly all malarial infections in humans, but the clinical features vary according to the causative species. Among them, Plasmodium falcifarum malaria is associated with numerous complications such as renal failure, cerebral malaria, and DIC, but Plasmodium vivax malaria usually has benign course. The proposed mechanism is blockage of microcirculation to vital organ by sequestration of parasitized erythrocytes. In Korea, for recent 20 years, there have been increasing numbers of malaria infection especially at North area of Geonggi-do. But serious complications in association with Plasmodium vivax malaria are rarely reported. Recently we experienced a case of Plasmodium vivax infection complicated by acute renal failure and report it with literature review.
Acute Kidney Injury ; Dacarbazine ; Humans ; Korea ; Malaria ; Malaria, Cerebral ; Malaria, Vivax ; Microcirculation ; Plasmodium ; Plasmodium vivax ; Renal Insufficiency

Vivax malaria reemerged in the Republic of Korea in 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there is only a small number of case reports on severe complications in vivax malaria. We report a unique case of P. vivax infection complicated by seizure and shock. A 58 year-old male showed generalized tonic-clonic seizure and shock after P. vivax infection. The species of malarial parasite was identified using peripheral blood film examination and polymerase chain reaction (PCR). He successfully recovered after treatment with hydroxychloroquine.
Humans ; Hydroxychloroquine ; Malaria ; Malaria, Cerebral ; Malaria, Vivax* ; Male ; Middle Aged ; Parasites ; Plasmodium vivax ; Polymerase Chain Reaction ; Republic of Korea ; Seizures* ; Shock*

Vivax malaria reemerged in the Republic of Korea in 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there is only a small number of case reports on severe complications in vivax malaria. We report a unique case of P. vivax infection complicated by seizure and shock. A 58 year-old male showed generalized tonic-clonic seizure and shock after P. vivax infection. The species of malarial parasite was identified using peripheral blood film examination and polymerase chain reaction (PCR). He successfully recovered after treatment with hydroxychloroquine.
Humans ; Hydroxychloroquine ; Malaria ; Malaria, Cerebral ; Malaria, Vivax* ; Male ; Middle Aged ; Parasites ; Plasmodium vivax ; Polymerase Chain Reaction ; Republic of Korea ; Seizures* ; Shock*

The study was conducted to assess the effectiveness of the artesunate in 7-day treatment course on uncomplicated P.falciparum malaria from August to December 2003, in the Phuoc Hoa and Phuoc Thang communes, Bac Ai district, Ninh Thuan province. The clinical trials were implemented in conformity with the WHO Guidelines 2001. Artesunate with total dose of 16 mg/kg body weight was used for 7days in 159 patients with uncomplicated P. falciparum malaria. The oral treatment of patients was supervised strictly; the clinical assessment and parasite density were followed up during 28 days after treatment. The number of patients completing 28-day follow-up was 131 cases. The trial results showed that the success rate of treatment was 122/131 (accounting for 93.1%) cases, the mean fever clearance time (mean +/- SD) was 1.2:+/- 0.4 days, the mean parasite clearance time was 1.8+/- 0.7 days and the rate of late treatment failure was 9/131 cases (6.9%)
Malaria ; Malaria, ; Falciparum ; Artemisinins