Animals ; Burns ; drug therapy ; metabolism ; physiopathology ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Female ; Male ; Mesentery ; blood supply ; Microvessels ; drug effects ; physiopathology ; Phytotherapy ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase ; metabolism ; Trillium ; chemistry

Animals ; Curcumin ; pharmacology ; Diabetes Mellitus, Experimental ; drug therapy ; Rats

Alzheimer Disease ; metabolism ; Animals ; Antioxidants ; metabolism ; Mice ; Polysaccharides ; pharmacology

Objective To Observe the effects of tumor necrosis factor ? (TNF ?) on cell proliferation and Intracellular free calcium concentraction ([Ca 2+ ]i) in endothelium of human umbilical vein endothelial cells (HUVEC) and investigate the pathogenesis of pregnancy induced hypertension syndrome (PIH). Methods Confluent monolayer of HUVEC was directly incubated with TNF ? at following final concentrations: 500, 1 000, 2 000 U/ml for 24 hours. The percentages of different cellcycles and [Ca 2+ ]i were measured by flow cytometry and fluorospectrophotometry. Results Incubated with TNF ?, the endothelial cells were elongated and transformed into fibroblast like cells. Border of nucleus was sharp, clarity, and cells were in regular shape. But there were abnormal granules in cytoplasma and some cells detached at the concentrotion of 2 000 U/ml of TNF ?. Stimulated by TNF ?, the percentage of cellcycles from phase G 0+G 1 to S and G 2+M decreased significantly and it was dose dependent. [Ca 2+ ]i increased significantly and dose dependent as well. Conclusion TNF ? may injure endothelium directly and inhibit its proliferation and repair through the changes of [Ca 2+ ]i level. It may play an important role in the pathogenesis of PIH.

Anti-Inflammatory Agents ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Ear Cartilage ; Female ; Humans ; Integrative Medicine ; methods ; Middle Aged ; Panniculitis ; complications ; drug therapy ; Phytotherapy ; Polychondritis, Relapsing ; complications ; drug therapy ; Prednisone ; therapeutic use ; Treatment Outcome

Purpose:To analyze the differences between prem enopausal and postmenopausal female patients with T1 primary breast cancer as to pathological classification, rate of lymphatic metastasis and some relative rec eptors, and to discuss the appropriate mode of operation to T1 breast cancer. Methods:154 patients with T1 primary breast cancer were retrosp ectively divided into premenopausal group and postmenopausal group. The clinical data of the two groups were compared. Results:There were no significant statistical differences in pr imary tumor size, but the incidence rate(62.2%) of invasive ductal cancer in po stmenopausal group was less than that(84.7%) of postmenopausal group(P

Animals ; Drugs, Chinese Herbal ; administration & dosage ; therapeutic use ; Ischemic Preconditioning, Myocardial ; methods ; Male ; Myocardial Ischemia ; prevention & control ; Myocardial Reperfusion Injury ; prevention & control ; Rabbits

Aging ; drug effects ; Animals ; Astragalus Plant ; Blood ; metabolism ; Brain ; metabolism ; Female ; Glutathione Peroxidase ; metabolism ; Liver ; metabolism ; Male ; Malondialdehyde ; metabolism ; Mice ; Mice, Inbred Strains ; Polysaccharides ; pharmacology ; Superoxide Dismutase ; metabolism

China ; Haplopappus ; Humans ; Phytotherapy ; Sesquiterpenes

Objective To investigate the relationship between postoperative cognitive dysfunc-tion and plasma cortisol levels in aged patients undergoing total hip replacement surgery. Methods Ninety patients aged 65-75 years old,scheduled for total hip replacement surgery under general anesthesia were enrolled in the present study.Cognitive state was tested by mini-mental state examination (MMSE).The patients were divided into two groups,POCD group and non-POCD group.Perioperative plasma levels of cortisol were determined on 2 d preoperative,2 d postoperative and 7 d postoperative.Results Incidence of POCD after 7 d in aged patients undergoing total hip re-placement surgery was 37.8%.Compared with day 2 d preoperative,plasma cortisol levels in POCD patients significantly increased on 2 d and 7 d post operation (P <0.01 or P <0.05).Compared with non-POCD patients,cortisol levels on the 2 d and 7 d postoperative day significantly increased in POCD patients (P <0.05).Plasma cortisol levels showed a negative correlation with MMSE scores on postoperative 2 d and 7 d(P <0.01).Conclusion Elderly patients have a relatively higher incidence of POCD after hip replacement surgery.POCD may be caused by high plasma cortisol levels in elderly patients following hip replacement surgery under general anesthesia.