1.Study of hemophagocytic lymphohistiocytosis in children.
Wen LIN ; Yan XIAO ; Run-ming JIN
Chinese Journal of Pediatrics 2003;41(10):792-794
2.Effect of high-flux hemodialysis on mineral and bone metabolism of patients with diabetic kidney disease undergoing maintenance hemodialysis
Xiangdong LIN ; Zhenfen HU ; Xiao JIN
Journal of Endocrine Surgery 2014;(6):456-458
Objective To investigate the effect of high-flux hemodialysis on mineral and bone metabo-lism( MBD) in diabetic kidney disease patients with maintenance hemodialysis .Methods 60 cases with diabetic kidney disease undergoing maintenance hemodialysis were studied and they were randomly divided into two groups according to the number table method .Patients in each group were treated using either high-flux dialyzer or low-flux dialyzer for 6 months.Blood calcium(Ca), blood phosphorus(P), calcium*phosphorus(Ca*P), alkaline phosphatase(AKP), parathyroid hormone(PTH), and 25 hydroxy vitamin D3(25-OH-D3),etc were deter-mined at the start and end of the study .Results In high flux dialysis group , serum P, serum Ca*P, and PTH levels was(1.52 ±0.50)mmol/L,(3.05 ±1.19)pg/L and(368.61 ±235.32)pg/L respectively, which was sig-nificantly decreased than before treatment ((1.78 ±0.55)mmol/L,(3.94 ±1.31),(427.45 ±288.93)pg/L) (P<0.05), while serum Ca, and 25-OH-D3 levels were(2.3 ±0.16)mmol/L and(21.64 ±8.51)nmol/L respectively, which were increased significantly than before treatment ((2.12 ±0.18)mmol/L,(16.77 ±7.69) nmol/L)(P<0.05), yet in low flux dialysis group serum Ca, P, AKP, PTH, and 25-OH-D3 didn't change sig-nificantly before and after treatment ( P>0.05) .Conclusion High-flux dialyser provides a better effect on MBD for patients with diabetic kidney disease undergoing maintenance hemodialysis .
3.Effects of Various Antihypertensive Drugs on Arterial Elasticity in Patients with Essential Hypertension
Xiao-Rong ZHENG ; Jin-Xiu LIN ;
Chinese Journal of Hypertension 2007;0(05):-
0.05).Heart rate was significantly slow in bisoprolol group(after treatment:66?4 vs before treatment:74?7 beats/min,P
5.Expressions and Significances of Caveolin-1 and Tight Junction Proteins in Schistosomiasis Colitis in Mice
Lin ZHANG ; Jin LI ; Xue LIN ; Jun XIAO
Chinese Journal of Gastroenterology 2017;22(3):147-151
Intestinal schistosomiasis is a kind of intravascular parasitic diseases, and chronic inflammation of colon is one of the basic pathological changes of the sickness.However, the mechanism of caveolin-1 and tight junction proteins in the pathogenesis of intestinal schistosomiasis is still unclear.Aims: To study the expressions and significances of caveolin-1 and tight junction protein occludin, claudin-1 in schistosomiasis colitis in mice.Methods: Forty BALB/c male mice were randomly divided into control group and infection group.Schistosomiasis colitis model was established by placing 40 Schistosoma Japonicum cercarie on the abdomen.Mice were sacrificed after 8 weeks.HE staining was performed.The permeability of intestinal vascular endothelium was detected by Evans blue method.The leukocyte counts in peritoneal lavage fluid were measured.qPCR was used to determine the mRNA expressions of caveolin-1, occludin, claudin-1 and eNOS in colon tissue.Western blotting and immunohistochemistry were used to detect the protein expressions of caveolin-1 and occludin.Results: Large number of egg granuloma was observed in colon submucosa and accompanied by extensive inflammatory cells infiltration in infection group.Compared with control group, content of Evans blue and leukocyte counts in peritoneal lavage fluid were significantly increased (P<0.05);mRNA expressions of caveolin-1, occludin, claudin-1 were significantly decreased (P<0.01);protein expressions and positivity rates of caveolin-1 and occludin were significantly decreased in infection group (P<0.05).Conclusions: Down-regulation of expressions of caveolin-1, occludin and claudin-1 can induce leukocyte accumulation via increasing the permeability of intestinal vascular endothelial cells, thereby involving in the development of schistosomiasis colitis.
8.Attentional bias of low trait anxiety college students with or without fear-induced mood to emotional faces
Guozhi LIN ; Guanghui DENG ; Min JING ; Xiao JIN
Journal of Third Military Medical University 1984;0(01):-
Objective To investigate the attentional bias for emotionally faces in subjects with low-trait anxiety when they are under normal or induce-fear emotion.Methods Trait anxiety inquiry(T-AI) were used to evaluate the mental health status of 480 freshman in a university,and 450 valid questionnaires were obtained.Among them,90 students were identified as low trait anxiety.Sixty students from them were randomized into 2 group(n=30) to receive a dot-probe task with emotional face as stimulus.They were asked to judge the target.The attentional bias under normal or fear-induced emotion to the emotionally faces was examined.Results Low trait anxious college students showed attentional avoidance to the negative faces when they were under normal emotion [D=(-11.09?25.40),t=-2.391,P=0.024],and the orientation was significant [OI=(-20.28?22.90),t=-4.850,P0.05].Conclusion Low trait anxious college students have attentional avoidance to negative faces because of orientation,but the avoidance will disappear when they are under fear emotion.
9.Normal macular thickness in healthy Asian yellow race children
Si CHEN ; Lin XIAO ; Xiaofang REN ; Enzong JIN
Chinese Journal of Medical Science Research Management 2013;26(4):281-284
Objective To study the normal macular thickness in children provide reference for the diagnosis of macular thickness abnormity in teenagers.Methods Databases including Wanfang,Pubmed and some others were searched for studies on macular thickness in Asian children.Data of macular thickness were extracted and were merged into only one by formulae.Results 12 studies were enrolled.The mean foveal minimum and central macular thickness were 143.89±17.32μm(n=2062 eyes) and 181.60±17.93μm(n=1974 eyes),respectively.The eight areas of inner circle (1~3mm diameter) and the outer circle (3~6mm diameter) macular thickness were also calculated.The central macular area seemed thicker in pre-school children than school children.Conclusion Chidren's macular thickness have different characteristic from adults',so it is important to take age,refraction,axial length,race and sex into account before making an abnormal macular thickness diagnosis.Meanwhile,a large sample of population-based cross-sectional study in children is necessary for a more effective standard.
10.Clinical exploration based on cost analysis: costs among different screening methods for myopia in school-aged children
Si CHEN ; Enzong JIN ; Xiaofang REN ; Jinglei YAO ; Lin XIAO
Chinese Journal of Medical Science Research Management 2013;26(6):427-429
To explore an easily executive and conveniently generalized method with effectiveness and low costing for myopia screening at the early stage.Research was performed to testify the reasonability of using axial length/corneal radius (AL/CR) for myopia screening in children by comparing the cost between AL/CR plus vision acuity (VA) and simple VA examination.Chinese school-aged children in Yangfang school district,Beijing (n=1427,aged 6~12 years old) were randomly grouped for either pure VA examination or for VA plus AL/CR examination.Those suspicious myopic children were informed for further refractive examination.Finally,the cost from screening to definite diagnosis of refractive error was calculated.Generally,compared with VA examination,the total cost was reduced by 15.12% and by 12.34%,respectively,in the elder group using VA plus AL/CR examination.VA plus AL/CR examination is an economical and reasonable method for screening suspicious myopia in Chinese school-aged children compared with pure VA examination.