7.Advances in Research on Hepatitis B Virus DNA Integration
Virologica Sinica 2008;23(2):93-99
Since HBV DNA integration was discovered for the first time in 1980, various methods have been used to detect and study it, such as Southern Blot, in situ hybridization, polymerase chain reaction and so on. HBV DNA integration is thought to be random on the whole although some hot spots of integration were described by some researchers, one of which might be the repetitive sequences of the genomic DNA. Besides, DNA damage, especially double-strand breaks could promote HBV DNA integration into host genome. HBV DNA integration into cells may damage the stability of the genome, cause DNA rearrangement, promote DNA deletion and induce the formation of HCC.
8.The progress of low-dose chemotherapy in neuroblastoma
International Journal of Pediatrics 2012;39(3):301-303
Low-dose chemotherapy is concerned in treating malignant tumor in recent years.The lowdose,metronomic chemotherapy is not only effective in antiangiogenic,but also avoid chemotherapy side effects,such as suppression of bone marrow,dysfunction of liver and kidney,gastrointestinal reaction and drug resistance.Thereby it can increase patient compliance,improve life quality and prolong survival time.Currently chemotherapy in neuroblastoma still plays a key role,especially low-dose chemotherapy,which can protect self-immune function and reduce the physical injury in children.
Result Analysis
Print
Save
E-mail