Sudden cardiac arrest is one of the critical clinical syndromes in emergency situations. A cardiopulmonary resuscitation (CPR) is a necessary curing means for those patients with sudden cardiac arrest. In order to simulate effectively the hemodynamic effects of human under AEI-CPR, which is active compression-decompression CPR coupled with enhanced external counter-pulsation and inspiratory impedance threshold valve, and research physiological parameters of each part of lower limbs in more detail, a CPR simulation model established by Babbs was refined. The part of lower limbs was divided into iliac, thigh and calf, which had 15 physiological parameters. Then, these 15 physiological parameters based on genetic algorithm were optimized, and ideal simulation results were obtained finally.
Algorithms ; Cardiopulmonary Resuscitation ; Death, Sudden, Cardiac ; Electric Impedance ; Hemodynamics ; Humans ; Leg ; Models, Cardiovascular

· Mesenchymal stem cells ( MSCs ) are a population of multipotent stem cells with various neurotrophins from bone marrow which are widely used in tissue, cell repair and alternative research.Recently, some researches have shown that MSCs could enhance the viability of neurons under a pathological circumstance by secreting some neurotrophins. So the neuroprotection of MSCs can provide a new method of the treatment on retinopathy that it possible to promote cells survial and functional recovery.Here we make a brief review on the secretory function of neurotrophin and neuroprotective effects of MSCs on retinal cells and its application in the treatment of retinal disease.

Objective To explore the influence of follow-up by telephone on adherence and quality of life for breast cancer patients with hormonal therapy.Methods Totally 78 breast cancer patients with hormonal therapy were divided into the intervention group (40 cases) and the control group (38 cases).The control group were carried on routine guidance treatment and enjoined regular subsequent visit.The patients in intervention group were carried on the above-mentioned treatment and also receive regular follow-up by telephone.Through the follow-up by telephone we provided guidance for present and will present problems.Adherence for breast cancer patients with hormonal therapy and cancer rehabilitation evaluation system-short form(CARES-SF) were used to investigate the patients' adherence and quality of life six month after the intervention.Then we compared the adherence and quality of life before,six month of the intervention.The changes of adherence and quality of life scores were analyzed by repeated-measure ANOVA.Results The score of quality of life in the intervention group after 6 month of intervention was (25.43 ± 6.04),while in the control group was (40.61 ± 7.73),the difference was significant between the two groups,P＜0.05.The score of medication adherence in the intervention group after 6 month of intervention was (8.57 ± 6.20),while in the control group was (14.12 ± 6.63),the difference was significant between the two groups,P＜0.05.Conclusion Follow-up by telephone can improve adherence and quality of life for breast cancer patients with hormonal therapy.

With the development of mass spectrometry technology and its wide range of applications in the biological field,Veristrat classifier has been applied in non-small cell lung cancer (NSCLC) individualized therapy as well as in other tumors.Oncologists select individualized treatment plan based on peripheral blood veristrat test results.Many trials have verified its guiding role in NSCLC and other tumors' s first line and multi-line individualized therapy.Veristrat classifier provides a new idea and method for individualized treatment of NSCLC and other tumors.

Objective To study the expression changes and profiles of nuclear structure and biogenesis-related genes in rat liver regeneration(LR). Methods Genes involved in nuclear structure and biogenesis were obtained by data collection and literature review.The gene expression changes during LR were checked by Rat Genome 230 2.0 array,and LR-related genes were identified by comparing gene expression difference between partial hepatectomy(PH) and sham operation(SO) groups.Results 406 genes were found to be LR-related.The numbers of initially and totally expressed genes occurring in the forepart(0.5-4 hours after PH) of LR,the prophase(6-12 hours after PH),the metaphase(12-66 hours after PH),and the anaphase(72-168 hours after PH) were 200,29,179,5 and 374,290,1?876,603,respectively.The numbers of their up-regulation and down-regulation were 1?224 and 496 times.The elevated transcription levels occur red to the nuclear organization and biogenesis-involved genes in the prophase and the metaphase of LR and to the nuclear membrane,nuclear matrix and nucleoplasm-involved genes in the metaphase;nuclear chromosome,nucleolus and nuclear functional protein complex-involved genes were up-regulated in the metaphase and the anaphase.Conclusion The expression of nuclear structure and biogenesis-related genes was active during LR,and it was tightly related with LR.

Objective To discuss the procedural problems and solution correlatively of CT-guided percutaneous biopsy of spinal diseases,with simultaneous evaluation of the safety and clinical application.Methods Sixty-eight cases with spinal diseases were taken CT-guided percutaneous biopsy under local anesthesia and CT guidance,including 9 in cervical spine,19 in thoracic spine,28 in lumbar spine and 12 in sacral spine.The program of carrying out the procedure was decided according to the site,approach route of the lesion with the destination of sampling,under CT guidance.Results The successful rate of needle puncture was 100%(68/68)with diagnostic accuracy of 92.6%(63/68),and false-negative rate of 7.4%(5/68),together with complications rate of 5.9%(4/68).Conclusions CT-guided vertebral biopsy is safe,reliable,less complication,high accuracy and together with clear demonstration of the position of puncture needle and the complex anatomic structures nearby,providing basic information for further clinical treatment and worthy to be recommended.

Objective To determine the relationship between preoperative plasma D-dimer level and the lymphnode metastasis characteristics in colorectal cancer patients.Methods A total of 106 patients with colorectal cancer were studied in order to evaluate this relationship.Their preoperative plasma D-dimer levels were measured.Results were correlated with the clinicopathological findings.Results Significantly different plasma D-dimer levels were found with respect to histologic N(P ＜ 0.001).The number of lymph node metastases was found to have the strongest association with D-dimer level among the significant clinicopathologic factors (Spearman rank correlation,P ＜0.001).The most useful cutoff of the plasma D-dimer levels for diagnosis of lymph node metastasis was determined to be 0.4 μg/mL.Conclusion Plasma D-dimer levels can help assess lymph node metastasis in patients with eophageal cancer and should be measured preoperatively.

Objective To evaluate the clinical value of fetal holoprosencephaly complicated with face malformation by two-dimensional(2D) and three-dimensional(3D) ultrasonography.Methods Fetal faces and brains were examined regularly with 3D ultrasonography when they were suspected abnormal with 2D ultrasonography and compaired the diagnoses with postnatal or induced delivery results.Results 11 cases of holoprosencephaly complicated with face malformation were diagnosed using 2D and 3D ultrasonography.Among these cases,there were 4 with single median mostril,2 with proboscis,2 with cheiloschisis,2 with multipte face malformation,1 with arhinia.They were all comfirmed by postnatal or induced delivery.Conclusions 3D ultrasonography provides visualized,three-dimensional,more precise and clearly fetal structure imagine.It has important supplement to 2D ultrasonography.2D ultrasonography combined with 3D ultrasonography can greatly enhance the diagnosis rate to holoprosencephaly complicated with face malformation.

Orthodontics in China has experienced two important stages. At its early stage from 1950 s to 1970 s orthodontics was a division of prosthodontic department in China. There were 3 top professors in this field, who got partly training at one time or another in USA and returned to China working in Beijing Medical College, the Fourth Military Medical University and Shanghai Second Medical College. Among them, Professor Mao of Beijing Medical College was regarded as the father of Chinese Orthodontics. Removable appliance was the main tool at that stage and Prof.Mao brought forward Mao’s Classification of Malocclusion which is still used in China. The rapid developing stage began in the 1980 s when China opened its door to the world. More and more orthodontists got further training abroad and brought back advanced techniques since then. Up to now, we have already had more than one thousand of orthodontic specialists and established its own organization——the Chinese Orthodontic Society (COS), which holds domestic orthodontic meetings and organize its members to attend international meetings. Right now, almost all advanced techniques in diagnosis and treatment are adopted in China, including 3D imaging, self-ligating bracket appliance, and implant anchorage. Chinese orthodontists have started to present or publish papers in international meetings and journals and more than tiat, started to develop new app-liances, such as Driving-Force Straight Wire Appliance, which has shown advantages in treating skeletal Class Ⅲ malocclusion.