Objective: To Search for the influence of Antiepileptic drugs on bone metabolism in children, Design Case-Control research Patients and Other Participants 20 Child patients with taking antiepileptic drugs for a long time(AEDs group), the longest thae of taking medicine is 6 years and the shortest is 0.5 year. There are15 epileptic patients without taking antiepileptic rugs in the no n-AEDs group and 30 health childrenin control group. Measurement Methods Alkaline phosphatase(AKP) and tarstrate-resistant acid phosphatase (TR-ACP) were determined by improved Kind-King method and Bessey-Lowry method respectively. Ca-lcium (Ca) and ph?sph?rus (P) in the blood were determined by 400E type auto-biochemistry analyzer. Results The AKP activities of ADEs. non-ADEs and control group are 190?47、144?38、143?40IU/L respectively, There are significant difference between ADEs. non-ADEs group, and ADEs, con-trol group (P20CIU/L, 2 patients with hypoealcemiaand 2 patients with hypophosphorum. TR-ACP activities. Ca and P levels are not significant diffe-reuce among the group?. Conclusions Taking antiepileptic drugs bas influeare ou bone metabolism in children.