The management of laryngeal cancer and hypopharyngeal cancer has fundamentally changed over the recent years. The optimum treatment protocols should pay close attention to the survival rate and function preservation. The purpose of this article we aimed to define the prevalence of intervention of laryngeal cancer and hypopharyngeal cancer, such as open operation, CO2 laser and non-invasive treatments, and measures that may facilitate standardization of such practices.

Humans ; Hypopharyngeal Neoplasms ; therapy ; Laryngeal Neoplasms ; therapy

Gastric cancer is the common malignant tumor of digestive tract,and liver metastasis in patients with advanced gastric carcinoma is the most common cause of death.The early diagnoisis of Liver metastasis of gastric cancer in patients with early diagnosis would help to improve the patient' s quality of life and prognosis.Briefly review the blood,imaging and pathological biopsy method in early diagnosis of liver metastasis of gastric cancer.However it is difficult for this.Researchers over the world should have more exchanges in order to develop guiding principles in the end.

Objective To discuss the influence of follow-up intervention on disease control of pa-tients with diabetes mellitus. Methods 160 patients who received education about diabetes mellitus were divided into the intervention group and the control group randomly according to the date of dis-charge with 80 patients in each group.The intervention group was given regular follow-up visit (including telephone fol-low-up) which lasted 12 months.The control group received no regular foUow-up.The health behavior,self-management ability and alleviation state of cognition level,fast glucose, glycosylated hemoglobin were com-pared after intervention between the two groups by t test andχ2 test. Results The health behavior,self-management ability and alleviation state of cognition level in the intervention group were better than those of the control group.The blood glucose 6 and 12 months after discharge was higher than that at the time of dis-charge and that of the intervention group at the same time point.The glyeosylated hemoglobin of the interven-tion group was reduced 6 and 12 months after discharge compared with that at the time of dis-charge. Conclusions Out-of-hospital follow-up is an effective method to extend hospital health educa-tion to patients' home. It can instruct and supervise the patients to assume the responsibility of subsequent targets control,so it plays a positive role in the blood glucose control,improvement of life quality and promo-tion of psychological and physical health.It is worthy of wide popularization.

OBJECTIVE:To establish the quality standard of Jinwu jiangu capsule. METHODS:Microscopy was used to identi-fy Panax notoginseng;TLC was used to identify Paeonia lactiflora and Sinomenii Caulis;HPLC was used to determine the content of paeoniflorin. The column was ZORBAX SB-C18 with mobile phase of acetonitrile-0.1% phosphoric acid(13∶87,V/V)at a flow rate of 1.0 ml/min,detection wavelength was 230 nm,column temperature was 30 ℃ and injection volume was 10 μl. RESULTS:Microscopy showed P. notoginseng had obvious features;P. lactiflora and Sinomenii Caulis in preparation were well-separated with clear spots. The linear range of paeoniflorin was 0.014-1.412 μg/μl(r=0.999 2);RSDs of precision,stability and reproducibility tests were lower than 2%;recovery was 95.73%-99.48%(RSD=1.54%,n=6). CONCLUSIONS:The method is simple,accurate and reproducible,and can be used for the quality control of Jinwu jiangu capsule.

The main factors which affect the farmers'participation in the new rural cooperative medical service are the problems,which exist in the system of the rural cooperative medical service,the institutions of medical service,the government and the farmers themselves etc.Only by constituting the corresponsive policy measures according to these factors can the farmers actively participate in the new rural cooperative medical service.

Objective · To observe the changes in peripheral blood CD14dimCD16+ monocyte count and serum C-reactive protein (CRP) level in elderly patients with chronic heart failure (CHF) and analyze the relationship between these changes and the cardiac function of patients. Methods · 42 elderly patients with CHF (the CHF group, consisting of 18 cases of NYHA cardiac function grade Ⅱ , 18 cases of NYHA cardiac function grade Ⅲ , and 6 cases of NYHA cardiac function grade Ⅳ) and 25 healthy elderly people (the control group) were enrolled. Peripheral blood CD14dimCD16+ monocyte count, serum CRP level, left ventricular ejection fraction (LVEF), and left ventricular end-diastolic diameter (LVEDD) were measured and statistical analysis was performed. Results · CD14dimCD16+ monocyte count and serum CRP level were significantly higher in the CHF group than in the control group (P<0.05). In the CHF group, the CD14dimCD16+ monocyte count, serum CRP level, and LVEDD of NYHA grade Ⅳ patients were significantly higher than those of NYHA grade Ⅱ patients, while their LVEF was remarkably lower than that of NYHA grade Ⅱ patients. The differences were statistically significant (P<0.05). Correlation analysis results showed that peripheral blood CD14dim CD16+ monocyte count and serum CRP level were positively correlated with LVEDD (r =0.37, r =0.45, P<0.05) and negatively correlated with LVEF (r =-0.56, r =-0.33, P<0.05) in the CHF group. Conclusion · The deterioration of elderly patients with CHF is associated with inflammation and the monocyte dysfunction may exist in the heart failure process. Peripheral blood CD14dim CD16+ monocyte count and serum CRP level are expected to be novel biomarkers that can reflect the severity of heart failure.

Objective To establish the quality standard of Shilong Qingxue Effervescent Granules. Method Rhizoma curcuma, flos sophorae, cornus officinalis and gamdir vine in Shilong Qingxue Effervescent Granules were identified by TLC. The content of gastrodin in Shilong Qingxue Effervescent Granules was determined by HPLC. Results The TLC spots were highly clear without the interference of negative samples and were reproductive. A good linear for gastrodin was in the range of 14～70 ?g/mL (r=0.999 9). The average recovery was 97.33% (RSD=0.63%). Conclusion This method is simple, rapid and accurate, and can be used for the quality control of Shilong Qingxue Effervescent Granules.

Research into methamphetamine-induced neurotoxicity has experienced a resurgence in recent years. This is due to an increased abuse of the substance internationally. The long-term abuse of methamphetamine will result in neurochemical, neuropathological and behavioral changes. Recent data implicate that dopamine oxidation, glutamate-induced excitotoxicity, disruption of mitochondria, and apoptosis are involved in the injury of methamphetamine to central nervous system. Further, Involvement of cell death-related genes in the neurotoxic effects of methamphetamine is also discussed.

Sudden infant death syndrome(SIDS) has become a highlighted topic in forensic medicine and pediatrics since it was firstly defined in 1969.As some great improvements were preceded in many aspects,people know more about its features,summarization,classification and related genes.There are many reports from developed areas such as North America,Europe,Australia,Japan etc.,but few from China.This review introduces SIDS's development history,new scientific findings and discusses the feasibility of further SIDS studies and the key points in forensic practice under the influence of San Diego definition of SIDS.