OBJECTIVE:To discuss the issue of how to take advantage of intellectual property law to promote the sus?tainable development of our traditional Chinese medicine,and to establish the related legal system to protect the intellectual property of traditional Chinese medicine.METHODS:On the basis of literature review,the necessity and foundation of establishing distinctive protective law on traditional Chinese medicine were discussed.RESULT:There were internationally precedents of legislation on biodiversity and cultural diversity;Neither“Trade-Related Aspects of Intellectual Property Rights”nor other WTO files forbad individual country to establish its own policy according to its specific situation,however,these policies should not be against the fundamental principle of WTO;Moreover,foreign countries is paying much more at?tention on legislation of traditional Chinese medicine and herb than they used to.DISCUSSION:It is of great necessity to establish the distinctive protective law on traditional Chinese medicine,which can best be enforced by promoting the self de?velopment of traditional Chinese medicine,especially the investment and innovation in this field.

Nowadays,more and more basic and clinical researches on absorbable internal fixators are car- fled out in China.This paper reviews the recent researches on biodegradation,absorption,and mechanical prop- erties of absorbable internal fixators,their effects on bone mineral density and structure and injury of epiphyseal plate,and their clinical applications.Some problems that have not been solved and future research key points are highlighted and discussed.

Thyroid cancer is more common in thyroid diseases, because of its slow growth and good prognosis, different scholars have different views on lymph node dissection. During the study of definition and positioning methods of sentinel lymph node biopsy, discuss the necessity of cervical node dissection and the application of cleaning scope in thyroid cancer surgery.
Humans ; Lymph Nodes ; pathology ; Sentinel Lymph Node Biopsy ; Thyroid Neoplasms ; diagnosis ; pathology

Treatment of chronic osteomyelitis has become a difficult problem in clinical medicine due to its extended pathological process,high occurrence of complication and recurrence of disease.The major pathogenesis mechanism is Gram-negative bacteria infection,such as staphylococci.LPS is an important substance found in the cell wall of Gram-negative bacteria and administration of LPS to skeleton relevant cells in vitro could simulate the pathological characteristics of osteomyelitis patients.The results of quantitative real-time PCR and Western blot showed that CHI3L1 was up-regulated obviously in the infected bone tissues of osteomyelitis patients and LPS-stimulated osteoblasts.Analysis of the luciferase activity of NF-?B reporter gene vector revealed that LPS could activate NF-?B.Bay11-7082,an inhibitor of NF-?B activation,suppressed the elevation of CHI3L1 expression induced by LPS.Pre-incubation of osteoblasts with anti-TNF-? antibody or silencing TNF-? receptor expression by siRNA inhibited the induction effect of LPS on CHI3L1.Inhibition of NF-?B activation also prevented up-regulation of TNF-? induced by LPS.In conclusion,LPS stimulated TNF-? expression through activating NF-?B,then TNF-? induced CHI3L1 expression.It was demonstrated for the first time that CHI3L1 expression is promoted in osteomyelitis and LPS-treated osteoblasts and investigates the molecular mechanism of LPS-induced CHI3L1 expression in osteoblasts.

Objective:To strengthen the management and improve the efficiency of medical equipment purchasing, promote the growth of hospital equipment resource value, find scientific equipment procurement ways and methods, establish standardized procurement mode, strive to the code of conduct for the extensive experience into the scientific method of procurement. Methods: Using Net Present Value(NPV) method in financial management on medical equipment purchasing economic benefit analysis, and combined with specific cases and data to analyze the procurement of medical equipment suppliers to provide the equipment procurement scheme.Results: On the assumption that the cost of capital rate is 10%, the three schemes are according to the straight line depreciation method, scheme a net present value for 6.96625 million yuan; scheme 2 net present value for 1.061918 million yuan; project net present value of 5.74608 million yuan; scheme 2 net present value, the second scheme, the net present value of the maximum. Net present value method is an important guarantee for hospital equipment purchase and scientific investment and improved management. Conclusion: Application of net present value method in the purchase of medical equipment show that in equipment procurement program diversification, multiple choice, with net present value method were quantified in order to provide the basis for decision-making, the use of net present value method and the traditional procurement scheme option compared to standards and the scientific nature of medical equipment procurement management, accuracy and objectivity of data analysis.

Objective:Using scientific methods, data analysis, improve the ability and level of medical equipment management.Methods: Using the investment return method, the payback period method and the guaranteed business method, the cost benefit analysis of medical equipment is carried out with the actual case(PET/CT).Results: Worked out according to the formula, the equipment in the operation for six years, the investment return rate reaches the highest 58.03%, 3 years basically to recover investment costs, annual check touchdowns 581 cases can achieve guaranteed business income 7558699.61 yuan(RMB).Conclusion: Through the cost-benefit analysis, it can track the benefits of the existing medical equipment, and can also estimate the benefits of the proposed medical equipment, and provide the decision-making basis for the hospital management.

Almost all multicellular organisms have a symbiotic relationship with prokaryotes in nature.In humans,the interaction between host and microbial flora is particularly important in the gastrointestinal tract.Technical and conceptual advances have enabled us to establish its role in human health and disease.Studies have shown that disorder of gut microbiota may participate in the development of metabolic diseases,such as obesity and type 2 diabetes.This review opens up new ideas to find strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases.

AlM: To observe the clinical results of pterygium excision combined with conjunctival autograft transplantation using fibrin glue.METHODS:A total of 60 patients (60 eyes) with primary nasal pterygium were randomly divided into two groups:the fibrin glue group ( experimental group, 30 eyes) and suture group ( control group, 30 eyes ) . All patients underwent pterygium excision combined with conjunctival autograft transplantation. ln the experimental group autograft was attached to sclera with fibrin glue while in control group 10-0 polyamide was used. The patients were followed up for 6mo. The time of operation, post operation comfort, complications and recurrence were evaluated.RESULTS:The average surgical time was 24. 5 ± 6. 5min with fibrin glue group while 35. 2 ± 5. 4min with suture group, with statistically significant difference between two groups (P<0. 05). Pain and foreign body sensation was significantly less with fibrin glue group than that in the control group ( P < 0. 05 ). No severe postoperative complication occurred both in two groups. The incidence of subconjunctival hemorrhage in the experimental group was lower than that in the control group (P<0. 05). 1 case (3%) of fibrin glue group, 3 cases (10%) of suture group had recurrence at the end of follow up 6mo.CONCLUSlON:lt's a safe and effective way to attach conjunctival autograft during pterygium surgery by fibrin glue. lt can reduce surgical time, postoperative complications and relieve postoperative discomfort.

Diabetic retinopathy ( DR ) due to disturbance of carbohydrate metabolism is the most serious ocular complication in patients with diabetic disease, and diabetic macular edema ( DME) is one of the main causes of vision loss. lt is considered that many factors are involved in DME pathological process. DME is defined as an abnormal thickening of the macular associated with the accumulation of excess fluid in the extracellular space of the neurosensory retina. Nowadays, the main treatment methods of DME include pharmacotherapy, laser photocoagulation and surgery. lnflammatory components within the vascular tissue play an important role in the development of DME, so drug therapy is an important method for DME. ln this review, we summarized the risk factors and the current pharmacotherapy situation of DME.

Objective To investigate influence of ureaplasma urealyticum(UU)infection on low genital tract during the pregnancy.The ureaplasma urealyticum was detected by the polymerase chain reaction(PCR) in women vaginal discharge. The patients were divided into infection group and control group.Results 624(25 68%) in 2430 cases of vaginal discharge had ureaplasma urealyticum infection. Infection rates of ureaplasma urealyticum was 24 53% in second trimester and 28 86% in third trimester respectively.184 cases (32 05%) of the premature rupture of membranes in infected group were significantly higher than 20 cases(22%) in control group. The UU infection incidence in small for gestation(SGA) age was increased in the infection group (45/574 vs 2/100)P