From the three aspects of university,family and the students themselves,the article points out that universities should transform the teaching thought and approaches and give the students poor in study the teaching guidance and humane care,parents should grasp the laxation of educating their children and students should pay attention to regulation and self-regulation.Only through the joint efforts,can the students walk out of study confusion to realize the healthy development

Discussions were made regarding the burden of persuasion and that of proof in tort lawsuits,distribution of the burden of persuasion in both medical tort cases and those in non-medical malpractice tort lawsuits.It is found that in cases involving tort of medical institutions,medical behavior tort and non-medical tort cases should be set apart depending on the nature of the lawsuit.Under the existing legal system,it is also necessary to distinguish the medical behavior tort incurred by medical malpractice from that irrelevant to malpractice.which will be critical for distribution of the burden proof and calculation of the compensation.

China ; Drugs, Chinese Herbal ; standards ; Ethics, Medical ; Humans ; Medicine, Chinese Traditional

The current graduate student curriculum of medical colleges and universities has not been able to satisfy the actual need of cultivating the medical graduate students. In certain extent it stresses the natural sciences, theory curriculum and knowledge instruction more than humanities social sciences,technical curriculum, and cultivation of students' ability. Based on the reform of our curriculum setup, the author put forward some suggestions such as expanding the course resources, enriching the content,implementing the second-level management system, being clear about the different cultivation flow and the curriculum name; paying attention to staff construction and perfecting graduate student curriculum assessment and so on.

BACKGROUND:To delay the onset of Alzheimer’s disease, transplantation of viable and wel-differentiated stem cel s is expected to repair neural tissue, which has been an issue of concern. OBJECTIVE:To explore the effects of different doses of human umbilical cord mesenchymal stem cel s (hUCMSCs) on learning and memory ability of Alzheimer’s disease rats. METHODS:Fifty Sprague-Dawley rats, 7 months of age, were randomized into normal, model, high-, middle-and low-dose hUCMSCs groups (n=10 per group). Rats in model and UCMSCs groups were used to make Alzheimer’s disease animals through intraperitoneal injection of 150 mg/kg D-galactose for 90 days, and rats in the normal group were given intraperitoneal injection of normal saline for 90 days. In the three hUCMSCs group, passage 3 hUCMSCs at doses of 1×105/0.2 mL/20 g, 5×105/0.2 mL/20 g, and 1×106/0.2 mL/20 g were injected via the tail vein, respectively. Forty-five days after cel transplantation, Morris water maze test was used to detect rat’s learning and memory abilities, and hematoxylin-eosin staining was used to observe pathological changes of the rat hippocampal CA1 region. RESULTS AND CONCLUSION:Compared with the normal group, the rats in the model group showed significant reduction in the ability of learning and memory. Compared with the model group, the escape latency was significantly shortened in the middle-dose hUCMSCs group (P<0.05), while the number of passing times through the platform was increased significantly (P<0.05). In the model group, the cel s in the hippocampal CA1 region were arranged irregularly with unclear nucleoli and a part of cel s were concentrated and deeply stained. In the middle-dose hUCMSCs group, the cel s in the hippocampal CA1 region were arranged regularly with clear nucleoli, and only individual cel s were stained deeply. These findings indicate that middle-dose hUCMSCs transplantation can improve the learning and memory abilities of Alzheimer’s rats.

Objective To evaluate the curative effect of valproate and levetiracetam in children with epilepsy.Methods32 patients in the first people's hospital of Xiaoshan district from March 2015 to November 2016 application of levetiracetam in treatment of children with epilepsy as the study group, another year over the same period in 35 cases of infantile epilepsy in children in our hospital using sodium valproate treatment as the observation group, two groups of children with different drugs in the treatment of the obtained to compare therapeutic effect.ResultsCompared with the control group (71.9%), the effective rate of the treatment group was significantly higher than that of the control group (P<0.05), and the effective rate was 85.7%.ConclusionSodium valproate is an ideal drug for the treatment of epilepsy in children, the two drugs have a certain anti epileptic effect, but compared to the effect of sodium valproate in the treatment of clinical advantages.

MicroRNAs(miRNAs) are a type of highly conserved,small non-coding RNAs,which powerfully regulate gene expression at the posttranscriptional level.In humans,it modulates about 30％ of protein coding genes.Ocular neovascularization is one of the most important clinical problems in ophthalmology and a common cause of blindness.Recent studieshavedemonstrated that miRNAs play a crucial rolein the development of ocular neovascularization.The use of miRNAs provides novel therapeutic approaches for ocular neovascularization.Here,we describe our understanding of the functions and expressions of miRNAs in eyes,the relationship among miRNAs,ocular neovascularization and angiogenic factors,and the current research of miRNAs in diabetic retinopathy.

Objective:To evaluate the efficacy and safety of controlled-release dinoprostone pessary(propess) in cervical ripening and intermediate labor induction.Methods:Eighty primiparas with uterogestation and Bishop score ≤6 points and no vaginal delivery taboo were equally divided into a study and a control group.The former received intravaginal administration of propess and the latter intravenous injection of low-dose oxytocin by the randomized control method.Comparisons were made of the Bishop score,delivery and the state of the fetuses and neonates between the two groups.The side effects of propess were observed.Results:Bishop scores were 7.75?2.227 and 6.38?2.862 in the study and the control group respectively 12 hours after the medication,significantly higher than 4.23?1.025 and 4.15?1.099 before the induction(P 0.05).The major side effect of propess was the over-frequent and over-strong contraction of the uterine,which occurred in 2 cases in the study group but subsided after its removal.Conclusion:Dinoprostone pessary,effective,safe and convenient,is obviously superior to oxytocin in cervical ripening and labor induction.

Fluorescence in situ hybridization (FISH) is a non-radioactive technique by use of fluorescently labeled DNA probes in detecting chromosomal alterations in cells. As a new molecular cytological method, it can detect various types of cytogenetic alterations, including deletion, amplification and translocation, as well as improve the accuracy of pathological diagnosis if combined with histomorphology. This review focuses on the application of FISH to the detection of some solid tumors.

Objective To explore the potential benefits of liver resection for patients with liver metastasis of pancreatic neuroendocrine tumors(PNETs).Methods We searched CNKI,CBM,MEDLINE,The Cochrane Library,EMBASE until Aug.2012 for identifying randomized trials.Randomized clinical trials(irrespective of language,blinding,or publication status)were collected to compare liver resection alone versus other unresected interventions(radiofrequency ablation,chemotherapy,hepatic arterial embolization,or drugs et al)in patients with liver metastasis from PNETs.Two authors independently identified trials for inclusion.The primary outcome was survival,treatment-related mortality(30-day mortality)and relief of symptoms.RevMan 5.1 software was used for Meta analysis.Results There was no meta-anlaysis,RCT,QRCT showing the clinical effect of operation for the treatment of pancreatic neuroendocrine tumor with liver metastasis.Only 6 cohort studies found were eligible and analyzed,involving 1020 patients.Compared with unresected treatment,the 3-year survival rate[OR =0.24,95％ CI (0.11,0.53),P =0.0004],the 5-year survival rate [OR =0.16,95 ％ CI (0.12,0.22),P ＜ 0.00001] and median survival time (109.5 ± 19.02 vs 31.2 ± 5.97 months,P ＜ 0.01) were significantly increased in liver resection alone.The symptom relief rate was substantially higher in the surgical group than in the non-surgical group(98.3 ±2.8 vs 62.5 ± 22.0,P ＜ 0.05).Perioperative mortality rate was lower in surgical group.Conclusions Surgical resection is the preferred treatment of PNETs in patients with liver metastasis.Surgery is safe and effective.Survival time is significantly extended and symptom relief rate significantly improves.Due to lack of randomized controlled trial (RCT),surgical resection for treatment of liver metastasis of PNETs requires further more randomized control study.