AIM: To observe the pathological role of 3-nitrotynosine (3-NT) on Escherichia coli LPS-induced vascular hyporeactivity in rats and the therapeutic effect of antioxidants. METHODS: Forty male SD rats weighting from 200 g to 250 g were randomly divided into four groups: the control group (n=10); LPS shock group (n=10); uric acid-treated group (n=10); melatonin-treated group (n=10). 6 h after LPS shock, phenylephrine (0.5-2.5 ?g?kg -1) was applied intravenously to all groups and the percentage increase in MAP was detected, respectively. The concentration-response curve of aorta rings from all groups rats were obtained by cumulative addition of phenylephrine (PE), and PE E_ max, EC_ 50 were calculated. The concentrations of plasma malondialdehyde (MDA), nitrate/nitrite and 3-NT were assayed in all groups 6 h after LPS shock. RESULTS: The MAP level induced by PE significantly decreased to 54.60% in LPS shock rats compared with the control (P

The concepts of Western medicine in treating tumor have changed markedly in recent years, and begun to put more emphasis on the whole survival status of patients. With recent emergence of targeted drugs, it was found that curative effects of the same targeted drugs in treating patients with the same tumor type even the same tumor pathological subtype but different therapeutic targets may be different. On the contrary, the curative effects of different targeted drugs in treating patients with different tumor types but the same therapeutic targets may be similar. Accordingly, the viewpoint of personalized therapy is advocated in Western medicine. Under the guidance of syndrome differentiation treatment in traditional Chinese medicine (TCM), patients with the same tumor and different syndromes should be treated by different herbs, and patients with different tumor and the same syndrome should be treated by the same herbs. Both the theories of "the same treatment for the same syndrome" and "the same treatment for the same therapeutic target" indicate that personalized therapy in Western medicine is similar to TCM syndrome differentiation treatment. The article focuses on "different treatments for the same disease" as well as "the same treatment for different diseases" to describe the similar points between personalized therapy and TCM syndrome differentiation treatment and thereby proves that TCM syndrome differentiation treatment is a scientific and essential approach in treating tumor. At the same time, the article also points out the problems and solution methods of TCM syndrome differentiation treatment.

Objective: To investigate the relationship between rater-ratee similarities/differences in some individual characteristics and organizational citizenship behavior(OCB) appraisal. Methods: 103 vertical dyads were assessed by Personality Scale for Enterprise Managers and Chinese OCB Scale. Results: There existed significantly positive correlations between similarities in seven demographic indices and other-oriented OCB dimensions; differences in personality traits correlated significantly negatively with some dimensions of OCB appraisal; age difference had non-liner regression relationship with other-oriented OCB dimensions.Conclusion: Similarities/differences of individual characteristics related closely with OCB appraisal.

By mean of the isolated perfused working heart model, the changes of myocardial contractile and relaxation functions, ventricular cell action potentials, myocardial oxygen and glucose consumptions etc. were observed at 1st,3rd, 8th and 24th h after burn injury in the guinea-pigs inflictedly III degree burn injury on 35% TBA. The results indicate that. 1 ) The contractile and relaxation functions go through a time course of 'normal-decrease-recover', i.e. the cardiac functions show a normal level within 1 h after burn injury. Then they are depressed gradually,and to the lowest at 8th h or so, after burn injury. The cardiac functions recover partly at 24th h after burn injury. It suggests that there is a repaired mechanism by itself in heart of the burn animal; 2 ) The depression of myocardial contractile and relaxation functions are related with depression of the oxygen consumption rather than reduce of intaking in nutrients; 3) the influencing factors of burn injury on the coronary flow and electrical activity of myocardial cells could be removed easily by the perfusate. It shows that these effects may be result from the extracardiac neurohumoral factors.

OBJECTIVE:To discuss the characteristics of drug-induced eye impairment.METHODS:206 cases of drug-induced eye impairment reported in internal medical journals published from Jan.1998 to Dec.2005 were analyzed statistically.RESULTS:The drug-induced eye impairment was mostly induced by anti-infective drugs,hormones,nervous system drugs.The impairment was manifested predominantly by glaucoma,keratitis,scleritis;retinopathy,hyphema,xeroma,damage of corneal epithelium and visual disorder etc.CONCLUSION:Clinicians should pay great attention to the drug-induced eye impairment for it can lead to a decline in eyesight or even loss of eyesight.

Objective To explore the relative factors and prognosis of upper gastrointestinal bleeding in patients with hepatic cirrhosis. Methods The clinical data of upper gastrointestinal bleeding of 502 inpatients from January 1990 to September 2004 were statistically analyzed. Results Males and middle-aged patients with hepatic cirrhosis occurred upper gastrointestinal bleeding more frequently, and the most commom causes were vessel rupture of esophage or gastric varices, portal hypertensive gastropathy, and peptic ulcer. The most common complications of upper gastrointestinal bleeding were severe bleeding shock, hepatic encephaopathy, hepatorenal syndrome,etc. Drinking wine and NSAIDs were the most common inducements of upper gastrointestinal bleeding. The efficient rate of medical management was 89.84%,the death rate was 10.16%, and the most common death causes were shock of severe bleeding, hepatic encephalopathy, and hepatorenal syndrome. Conclusion Sex,age, and season,etc. were related to upper gastrointestinal bleeding in patients with hepatic cirrhosis. Bleeding causes, liver function, complications, and age, etc. were factors affecting prognosis.

Idiopathic orbital inflammatory pseudotumor (IOIP) is a common ophthalmic disease that severely damages the visual acuity and countenance of the patient,its etiology and pathogenesis are unclear.Many hypotheses have been proposed,including infection,autoimmunity and neuroendocrine mechanism,etc..These hypotheses reflect certain aspects of the etiology and pathogenesis of IOIP and provide information for further understanding of the disease.The research progression in the etiology and pathogenesis of IOIP was reviewed.

In recent years,immunoglobulin G4-related disease (IgG4-related disease) has received increasingly attention in medical community as a novel clinical entity.Although its clinical manifestation varies,high serum IgG4 concentration and numerous IgG4-positive plasma c(c)ll infiltration are the common characteristics.IgG4-related disease involves many human organs,and most one is pancreas,followed by parotid gland,bile duct,liver,lung,lymph node and so on,and orbital involvement is relatively rare.Current initial research shows that there is certain association between orbital disease with IgG4,and these diseases mainly include benign lymphoepithelial lesion,idiopathic orbital inflammatory pseudotumor,Castleman ' s disease,xanthogranuloma,Rosai-Dorfman disease etc..The researching progression in the relationship between IgG4 and orbital diseases is reviewed.

Idiopathic orbital inflammatory pseudotumor (IOIP) is a common ophthalmic disease with uncertain etiology and pathogenesis.It charactarized by chronic inflammatory cell infiltration and connective tissue proliferation.At present,its clinical treatments mainly include pharmacotherapy,radiation therapy and surgery,and the primary treating drugs include glucocorticosteroids and immunosuppressive agents.The mainstay of therapy is systemic glucocorticosteroids,although there is an increasing trend toward the use of alkylating agents,antimetabolites,monoclonal antibodies and other immunosuppressive agents.The progress in clinical treatment of IOIP was reviewed.

Bacterial cellulose iunique and promising material aimplantand scaffoldin tissue engineering study.Iicomposed of pure cellulose nanofibemesh spun by bacteria.Aithigh watecontenand purity,iimore biocompatible fomultiple medical applications.In addition,iieasy to control itmechanical strength,chemical structure and morphology,therefore iimore suitable to be used abiomedical material in vivo.Bacterial cellulose habeen applied atissue engineering material in clinical medical aspects,foexample,wound dressingalternatives,artificial skin,artery eluting stent,bone tissue engineering scaffold,artificial blood vessel,artificial hearvalve prosthesis.The application of bacterial cellulose ialso extended to the construction of tissue engineering corneal stromand corneal contaclens.Thipapereviewthe progresin the applying spectrum of bacterial cellulose in corneal tissue engineering and othemedical field.