Atropine ; therapeutic use ; Humans ; Organophosphate Poisoning ; Poisoning ; drug therapy ; Quinuclidines ; therapeutic use

ObjectiveTo provide evidence for the education on sychological health for the undergraduates by analyzing the relationship among interpersonal relationship, coping style, self consistency and congruence of local college students. Methods uestionnaires about interpersonal relationship, coping style, and self consis tency and congruence have been carried out on a stratified random sample of 1471 students from four local colle ges. And all the data of the questionnaire scales will be dealt with by the software SPSS15.0. Results①Total scores on interpersonal relationship and self consistency and congruence of male college students( (9.88 ±5.51 );(93.29 ± 13.48 ) respectively) were much higher than the scores of the female college students ( ( 8.84 ± 5.11 );(90.09 ± 12.60) respectively). Total scores of the above two items for the seniors( ( 10.26 ± 5.89 ); ( 96.79 ±12.93) respectively) were obviously higher than the total scores of students of other grades. For the engineering students, whose total scores on the two items( ( 10.26 ±5.86); (93.57 ± 12.83 ) respectively) were remarkably higher than the scores of students of other majors. Regarding the various factors of coping style, there are signifi cant differences in gender, grade and major( P ＜ 0. 01 ). ②Concerning the college students, there were conspicu ous relationship among their interpersonal relationship, coping style, self consistency and congruence ( P ＜ 0.01 ). ③ Self consistency and congruence could be effectively predicted by factors, i.e. total score of interpersonai rela tionship, remorse, problem-solving, rationalizing, fantasy, recoil, help-seeking and grade. ConclusionCollege students' ability of self consistency and congruence is affected by their coping style and interpersonal relationship. To improve the individual' s ability of self consistency and congruence and the condition of their psychological health, the most effective way is to cultivate the capability on interpersonal communication and apply the positively flexible coping style.

?Objective: To study the craniofacial growth in Chinese girls. Methods: The hand wrist radiographs of 282 chinese girls aged 7 to 14 years old were analysed by CHN scoring method to assess their skeletal age. Furthermore, their lateral cephalometric films were taken and analysed with percentile method. The craniofacial growth percentile curves of the girls were made. Results:The fastest craniofacial growth in the girls took place at the age of 11 to 12. The growth of SN was not significant,but the mandibular length(Co-Gn) increased by 17.3 mm.Conclusion: The data may be reference for the jaw growth prediction

Recently, more and more public attention has been paid to nanomaterials in various fields. Especially, the preparation methods of core/shell nanoparticles have been drastically updated and developed. There exists great application prospect for the development of biosensing core/shell nanoparticles. This paper emphatically introduced the operation principle, preparation methods of biosensing core/shell nanopaticles and the latest application progress in electrochemical biosensor, optical biosensor and piezoelectric crystal biosensor.

Drug dependence has been a severe social and health problem,which has caused serious economic losses and social disorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.We have been contributed to the research of neurobiological mechanisms,clinical characteristics,and interventions of craving after withdrawal from addicting drugs.We have systemati-cally studied the change of drug seeking behavior and craving after withdrawal from cocaine,and further investigated the neural anatomic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.According to the situation of dug abuse in China,we investigated the characteristics in the expression of incubation of craving after withdrawal from opiate.We have primarily found the neural anatomic pathways and neural plasticity mechanisms which contribute to the process.We have also demonstrated the psychological characteristics and neurobiological mechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chronobiology and imaging.Our findings have provided evidence for effective inventions on preventing relapse after abstinence in addicts.Abstract:SUMM ARY Drug dependence has been a severe social and health problem,which has caused serious e-conom ic losses and social d isorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.W e have been contributed to the research of neurobiologicalmechanisms,clini-cal characteristics,and interventions of craving afterwithdrawal from add icting drugs.W e have systemati-cally stud ied the change of drug seeking behavior and craving afterwithdrawal from cocaine,and further investigated the neural anatom ic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.Accord ing to the situation of dug abuse in China,we in-vestigated the characteristics in the expression of incubation of craving after withdrawal from opiate.W e have primarily found the neural anatom ic pathways and neural plasticity mechanisms which contribute to the process.W e have also demonstrated the psychological characteristics and neurobiologicalmechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chrono-biology and imaging.Our find ings have provided evidence for effective inventions on preventing relapse after abstinence in add icts.

Objective: To establish the qualitative and quantitative standards for Yejuhua Granules (Flos Chrysanthemi Indici). Methods: The identification was carried out by TLC. Chlorogenic acid in preparation was determined by HPLC. The HPLC conditions were:Hypersil column (4.6nm?250 nm 5?L), mobile phase of acetonitrile-0.04% phosphoric acid solution (13∶87). Results: TLC method for the identification of Yejuhua Granules was specific. HPLC for the determination of chlorogenic acid in preparation was simple and quick, accurate and reliable. Conclusion: These methods can be used for the quality control of Yejuhua Granules.

Objective To observe the curative effect of abdominal acupuncture on postoperative pain of patients with mixed hemorrhoid after Milligan-Morgan hemorrhoidectomy.Methods A total of 100 mixed hemorrhoid patients with postoperative pain after Milligan-Morgan hemorrhoidectomy under spinal anaesthesia from September of 2014 to December of 2015 were included into the study.The patients were evenly randomized into trial group and control group.The trial group was treated with abdominal acupuncture at acupoints of Shuifen,Guanyuan,Qihai,Sanxing needles under Qihai,lower Fengshi,Tianshu for 15-30 min.The control group was treated with intramuscular injection of Tramadol Injection 0.1 g.Before treatment and 0.5,1,2,3 hours after treatment,the pain visual analogue scale (VAS) scores and body activity scores were recorded.Results (1) After treatment,pain VAS scores of the two groups at different time points were obviously decreased(P ＜ 0.05 compared with those before treatment),and the decrease of pain VAS scores of the treatment group 0.5 hours after treatment was superior to that of the control group (P ＜ 0.05),but there was no significant difference between the two groups at other time points (P ＞ 0.05).(2) After treatment,body activity scores of the two groups at different time points were obviously decreased(P ＜ 0.05 compared with those before treatment),but the difference was insignificant between the two groups(P＞ 0.05).(3) The average dose of Tramadol Injection used in the trial group was 0.013 ± 0.034 1 g,while was 0.103 ± 0.017 7 g in the control group,the difference being significant (P ＜ 0.05).Conclusion The analgesic effect of abdominal acupuncture is similar to that of Tramadol Injection.For its safety,and being cheap,practical and painless,abdominal acupuncture can be expected to be another option of effective analgesic method for the postoperative pain of patients with mixed hemorrhoid after Milligan-Morgan hemorrhoidectomy.

This study examined the effect of integrin cytoplasmic domain-associated protein 1α (ICAP-1α) and its mutatants T38A and I138A on the adhesion, migration and tube formation of 2H-11 cells. rAAV-ICAP-1α, rAAV-T38A and rAAV-I138A were constructed. After infection, the expression of ICAP-1α and p-ERK1/2, p-c-Jun protein was measured by Western blotting. Adhesion ability was evaluated by using MTT. Cell migration was determined by using Boyden chamber method. Tube formation test was conducted on Matrigel. The results showed that in ICAP-1α, T38A and I138A groups, ICAP-1α protein expression was increased. In T38A and I138A groups, phospho-ERK1/2, phospho-c-Jun protein expressions were significantly increased as compared with the control group and the GFP group. ICAP-1α group protein expression was obviously decreased when compared with the control group and the GFP group. Cell adhesion ratio was 0.1429±0.0080 in control group, 0.1434±0.0077 in GFP group and the ratio in T38A and I138A groups increased to 0.3210±0.0082 and 0.3250±0.0079, respectively. In ICAP-1α group, the ratio was decreased to 0.1005±0.0073. In T38A and I138A groups, the number of migrating 2H-11 cells was increased to 31.45±3.20 and 33.10±5.40 against 18.51±2.80 in control group and 20.47±3.12 in GFP group. In ICAP-1α group, the number was decreased to 12.06±1.72. The number of tube-like structures was increased to 20.41±2.54 in T38A and to 22.26±3.07 in I138A groups as compared to those of control group 12.45±1.84 and GFP group 13.63±2.71. In ICAP-1α group, the number of tube-like structures was decreased to 8.32±1.24. It was suggested that rAAV-T38A and rAAV-I138A transfection can substantially increase 2H-11 cell adhesion, migration and angiogenisis, while rAAV-ICAP-1α can greatly inhibit the effect. These effects might be correlated with ERK1/2 and c-Jun protein phosphorylation.

Objective To observe the change of platelet activity marker in hypertensive patients complicated with ischemic cardiovascular and cerebrovascular disease ,and assess it s value in the happening of thrombotic disease. Method The platelet activity marker (CD62p,CD63) were measured by flow cytometry in 40 hypertensive patients complicated with ischemic cardiovascular and cerebrovascular disease (group C ),46 hypertensive patients not complicated with ischemic cardiovascular and cerebrovascular disease (group B),and 30 cases of healthy control (group A). Comparison between three groups were made. The serum fibrinogen were measured at the same time. Result serum level of CD62p, and CD63 in group B,C are higher than group A.(P

We investigated the epidemiological characteristics of diarrheagenic Escherichia coli (E.coli) infection in Fujian Province,providing reference for the prevention and control of diarrhea epidemic and outbreak.Yanping and Yongan areas were selected as surveillance sites from year 2010 to 2015,where 1 950 samples were collected from the sentinel hospitals,and then samples were isolated and cultured on MacConkey agar plates.Suspected strains were identified by routine and molecular diag nosis technique methods.Results were analyzed by SPSS 17.0 software package.A total of 129 strains of diarrheagenic E.coli were isolated with a total detection rate of 6.62％.The detection rates of enteropathogenic E.coli(EPEC),enterotoxigenic E.coli(ETEC) and enteroadhesive E.coli(EAEC) were 3.33％,1.64％ and 1.64％ respectively (including 61 strains of atypical EPEC,4 strains of typical EPEC,and 32 strains of ETEC and EAEC for each),while EHEC and EIEC were not found.There was no significant difference between the detection rates of male and female.All the patients were divided into five groups according to the age,and there were no significant differences between the detection rates of EPEC,EAEC and ETEC in the 5 groups.The detection rates were the highest in August and September.There was no significant difference between the detection rates of rural area and uban area.There was also no significant difference between the composition ratio of diarrheagenic E.coli (DEC) in the two surveillance sites.In conclusion,there were three kinds of DEC in Fujian Province,and EPEC was the dominant.August and September were the months with the highest detection rates.Children age less than five and adult aged 20 59 years were the high risk groups with DEC infection.More attention should be attached on the rational treatment by antibiotic for DEC.