Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Objective:To investigate the in vivo behavior of colon-targeted thymosin ?1 (T?1) tablets. Methods: Colon-targeted T?1 tablets were labelled with ~(99m)Tc and were given to 6 healthy male volunteers orally. Gamma-scintigraphy was used to monitor the gastrointestinal transit and release site of the labelled drug. Results: The labelled drug became detectable in the colon 6.5 h after administration in 5 volunteers with normal intestinal peristalsis and 4.5 h after administration in 1 with sthenic intestinal peristalsis. The images caused by drug release became notable in the colon with the prolongation of releasing time. Conclusion: T?1 tablets is colon-targeted during drug delivery in human gastrointestinal tract.

AIM: To qualitatively analyse the marker peaks of Shanghuanglian Powder-Injection(Flos Lonicerae Japonicae,Radix Scutellariae,Fructus Forsythiae,etc.) fingerprints and determine their synergy. METHODS: The HPLC-PDA/ELSD fingerprints of Shuanghuanglian Powder Injection were compared with those of component herbs.The relative retention time of each peak,the Ultraviolet spectra providing by PDA and some pure standard substances were used in the analyses. RESULTS: Thirteen marker common peaks of HPLC-PDA(254 nm) fingerprint and HPLC-ELSD fingerprint were confirmed to the three component herbs respectively.Four marker peaks were identified as chlorogenic acid,caffeic acid,baicalin and phillyroside. CONCLUSION: Some marker peaks and their synergy origins can be identified by chromatographic fingerprint technology in the Chinese traditional patent medicine.

Malnutrition is a relatively common clinical problem.Some critically ill children have basic diseases,which lead to the increase of body metabolic rate.As a result,the incidence of malnutrition is higher than that of ordinary children.Malnutrition could decrease the immunity of critically ill children and increase the risk of infection and complications,then may prolong hospitalized course,affect prognosis,and increase mortality.Effective assessment of the nutritional starus of critically ill children as early as possible,detection of the malnutrition state timely,and conduction of clinical nutrition support ways,would promote the recovery of disease,and improve the prognosis.Currently international nutritional assessment methods consist of physical measurements,laboratory examination and nutritional risk screening.However,different nutrition assessment methods have different adaptability,as well as advantages and disadvantages.

Carcinoma, Non-Small-Cell Lung ; diagnosis ; genetics ; pathology ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lung Neoplasms ; diagnosis ; genetics ; pathology ; Oncogene Proteins, Fusion ; genetics ; metabolism ; Reverse Transcriptase Polymerase Chain Reaction

Objective To observe the clinical effect of Buyuan Capsule(Herbal capsule for tonification)and euthyrox on Hashimoto's hypothyroidism.Methods Totally 138 patients who consistent with the diagnostic standard of dysfunctional Hashimoto's thyroditis were randomized into two groups.The treatment group,70 cases,was treated with Buyuan capsule and euthyrox,and the control group,68 cases,was only given euthyrox.The level of thyroid hormone,thyroid antibody,and symptoms scores were assessed before and two months after treatment in both groups.Results Total effective rate in the treatment group was 94.3%,and 80.9% in the control group.A statistical difference existed between two groups(P

Objective To explore the effect of serum uric acid ( UA ) level and its change in the incidence of nonalcoholic fatty liver disease( NAFLD) . Methods Subjects who participated in the adult health examination in a Top Three Hospital Medical Center of Guangzhou Province in 2012 and 2015, according to whether they have suffered from NAFLD after 3 years follow?up,were divide into NAFLD incidence group and negative control group. The data of anthropometry, laboratory examination and abdominal ultrasound were retrospective analyzed. Results There were 91 male in NAFLD incidence group and 317 males in negative control group. There were statistical significance in body weight ( Wt ) , BMI, UA, TG, HDL?C at baseline ( t=6. 10,4. 98,4. 21,1. 91,-4. 06;P<0. 05). According to UA<149 μmol/L,more than or equal to 149 to<416μmol/L,more than or equal to 416μmol/L as grouping standard,males detection of NAFLD in each group were 0 case,55 cases ( 19. 1%) , 36 cases ( 30. 3%) , and the difference was statistically significant compared with negative control group(χ2=6. 28,P=0. 012). According to UA<89 μmol/L,more than or equal to 89 to <357μmol/L,more than or equal to 357 μmol/L as grouping standard, females detection of NAFLD in each group were 0 case,91 cases( 20. 0%) ,39 cases( 37. 9%) ,and the difference was statistically significant compared with negative control group(χ2=14. 87,P=0. 001) . Age?adjusted partial correlation analyze showed that serum UA levels were positively correlated with Wt,BMI,SBP,DBP,BUN,SCr,ALT,TG and LDL?C levels,and negatively correlated with HDL?C levels( r=0. 349,0. 248,0. 152,0. 157,0. 201,0. 251,0. 132,0. 191,0. 148,-0. 228,P<0. 05) . There was no statistical significance between the NAFLD incidence group and the negative control group in the change of serum UA( z=0. 811,P=0. 417) . Binary Logistic regression analyze showed that the incidence of NAFLD was closely related to BMI,UA,ALT,TG and HDL?C at baseline,and the changes of Wt,ALT,TG, HDL?C during follow?up ( OR ( 95%CI ): 0. 767 ( 0. 709-0. 830 ) , 0. 996 ( 0. 994-0. 998 ) , 0. 964 ( 0. 937-0. 992),0. 702(0. 516-0. 955),4. 948(2. 414-10. 144),0. 890(0. 852-0. 930),0. 957(0. 937-0. 979), 0. 601(0. 441-0. 818),3. 111(1. 197-8. 080),P<0. 05). Conclusion Serum UA level is closely related to the incidence of NAFLD and its related risk factors, and serum UA level is an independent risk factor for NAFLD.

OBJECTIVE To investigate the infections from semi-permanent intravenous catheter in hemodialysis patients.METHODS Retrospective analysis was applied from the clinical data to investigate the relationship between catheterization duration and infection occurrence in 35 hemodialysis patients who received semi-permanent intravenous catheter from Jan 2007 to Jan 2008.The average length of stay of the patients was 36 days and after discharge from hospital the follow-up was done by telephone.RESULTS Thirty-five cases of hemodialysis patients with semi-permanent intravenous catheter underwent 389 days of follow-up on average(5-26 months),without occurrence of related infections although there were 7 cases of skin redness which disappeared after treatment of sterilization and dressing replacement.CONCLUSIONS To effectively prevent infections,the following measures are important including strict aseptic operation,periodic degermation,dressing replacement,good catheter fixation,good quality of heparin tube closure,as well as the self-care education to patients and family members.

OBJECTIVE: To prepare fumeisong cream and establish its quality control method. METHODS: Ingredients including carbamide, triamcinolone acetonide acetate, camphor, and laurocapram were mixed in an oil-in-water matrix for preparation of fumeisong cream. HPLC was adopted to determine the content of triamcinolone acetonide in the cream. RESULTS: The prepared cream was white in color, with test items all in line with specifications stipulated in 2005 version of China Pharmacopoeia. The linearity concentration range of triamcinolone acetonide was 2.06～20.6 ?g?mL-1(r=0.999 6) and the average recovery rate was 99.6% (RSD=1.0%,n=9). CONCLUSION: The cream is simple and feasible in preparation techniques, and its quality is stable and controllable.

Clinical research progress of Traditional Chinese Medicine(TCM) on treatment of diabetic nephropathy in recent ten years was explained from aspects of pathogen and pathogenesis, patterns classification of TCM, Chinese herbal Compound, single drug and the extractive. And the result showed a good therapeutic effect on early stage of TCM treatment for diabetes mellitus which was worthy to be popularized.