Objective To evaluate the association between serum ferritin and the risk of cardiovascular disease among the Chinese population.Methods Based on the data from China Health and Nutrition Survey 2009, we used the Framingham risk score to calculate the 10-year risk of cardiovascular disease and analyzed the association between serum ferritin and the risk of cardiovascular disease in different gender by logistic regression analysis.Results Among 6 551 respondents, 3 035 (46.3%) were males and 3 516 ( 53.7%) were females whose mean age were ( 49.3 ±13.8 ) and ( 49.2 ±13.7 ) years, respectively.The median level of serum ferritin was 75.08 ( 36.71 -138.75 )μg/L.According to the 10-year risk of cardiovascular disease calculated by the Framingham risk score , the low risk group, middle risk group and high risk group were accounted for 79.5%( n=5 207 ) , 15.7% ( n=1 028 ) and 4.8%( n=316), respectively.The median of serum ferritin (121.61 vs.46.14, P<0.01) and the Framingham risk score (8.6 ±6.0 vs.7.3 ±1.6, P<0.01) of males were higher than those of females.The percentages of the middle risk group ( 30.6% vs.2.8%) and high risk group ( 9.8% vs.0.5%) of 10-year risk of cardiovascular disease in males were higher than those in females ( P <0.01 ).The 10-year risk of cardiovascular disease ≥10%increased with the increasing of serum ferritin in females ( trend P<0.01 ) but not in males.Conclusion Serum ferritin levels are positively correlated with the risk of cardiovascular disease in female Chinese.

To analyze the acupuncture treatment for impotence in 130 kinds of classical medical books by computer,and summarize the rules of acupuncture for this disease.The results showed that selection of acupoints along the meridians,selection of acupoints by boay parts,selection ofacupoints by pattern identification are the laws ofacupuncture for this disease.

Animals ; Erythrocytes ; physiology ; Oncorhynchus mykiss ; physiology ; Oxygen ; Water ; chemistry

Animals ; Breast Neoplasms ; metabolism ; Humans ; NF-kappa B ; metabolism ; Neoplasms ; metabolism ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; metabolism ; Proto-Oncogene Proteins c-bcl-2 ; metabolism ; Receptors, Notch ; metabolism ; physiology ; Signal Transduction

OBJECTIVE: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. METHODS: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ET(A)R blocker (BQ-123) group and ET-1+ET(B)R blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. RESULTS: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. CONCLUSION: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

OBJECTIVE: To establish a staging standard for a transplanted hepatoma model in rats, which may be equivalent to the human primary liver cancer. METHODS: A transplanted hepatoma model was made in SD rats by implantation of histologically intact Walker-256 tumor fragment into the left lateral lobe of the liver. The body weight, tumor volume and serum albumin level of the rats were measured and assayed in different periods. Pathological sections were also fabricated to detect the invasion and metastasis of the neighboring tissues. RESULTS: The body weight loss and ascites occurred at the 12th and 18th day separately. The serum albumin level was (35.32+/-2.45) g/L at the 11th day, which showed no statistical difference as compared with the healthy rats (P>0.05), and the albumin level at the 18th day was significantly lower than that at the 11th day (P<0.05). At the 23rd day, 56.25% of the rats developed bloody ascites. CONCLUSION: The period between 5-11 days in the model rats may be correspondent to the early stage of human primary liver cancer, and the biological behavior of the model rats at the18th day may be correspondent to the late stage of human primary liver cancer. This staging standard might be the guideline for model selection in experimental study of primary liver cancer.

Objective To investigate the immune effect and the security after inoculating rabies vaccine in children. Methods To investigate and to detect the antibody level by the way of ELISA among the 337 children wounded by animals and vaccined the rabies vaccine. Results The positive rate of the antibody is 99.7%, the ad-verse effect is moderate. Conclusion Domestic adjuvant-free aqueous rabies vaccine, domestic freeze dried rabies vaccine and peregrinus freeze dried rabies vaccine all have satisfactory immunogenicity and little adverse effect.

Objective To evaluate the value of clinical findings and different diagnostic criteria for the diagnosis of adult onset Still's disease (AOSD). Methods The AOSD patients admitted to Zhongshan Hospital affiliated to Fudan University from 2003 to 2009 were enrolled. Non-AOSD patients with fever were selected. Different diagnostic criteria of AOSD were applied to all patients. Two indenpendent samples t test and wilco-xon test were used for statistical analysis. Results The clinical features such as rash, arthralgia, arthroncus, sore throat, myalgia, lymph node enlargement, hepatomegaly, splenomegaly, leuko-cytosis, neutrophil ≥80% and serum level of ferrin≥ 2000 ng/ml hadhigher specificity (65.87%~98.41%) with 2.00～5.00 of the positive likelihood ratio.High fever ( ≥39.0℃), negative of ANA and RF had higher sensi-tivity (85.25%~93.65%). Combinations of three parameters such as high fever, rash, sore throat, leukocy-tosis, arthralgia had higher positive likelihood ratio. The specificity of ARA criteria was the highest. The sensitivity and accuracy of Yamaguchi criteria were the highest. Conclusion There is no single parameter that could be specific to the identification of AOSD. Combing with several parameters can improve the diagnostic efficiency. The results of this study have shown that the commonly used diagnostic criteria has high specificity.