1.On Teaching Reformation of Advanced Studying Doctors Specialized in Obstetrics and Gynecology
Chinese Journal of Medical Education Research 2006;0(12):-
Aiming at some problems existing in the cultivation of advanced studying doctors,we think that strict selection should be made to guide advanced studying doctors to have correct understanding of their specialty and systemic training to improve the training quality.
2.Discussion of the intervention of social work in hospice
Chinese Journal of Hospital Administration 1996;0(01):-
With the development of the human society, people have come to pay more and more attention not only to their life quality but also to the quality of their life before death. Hence the emergence of hospice. At present there are three types of hospice in China: the family type, the general hospital type, and the special institution type. Each of these types has its own shortcomings. Hence the need for social work to intervene in hospice. The paper discusses the viability and necessity of the intervention through the notion, channels and methods of intervention. The role of social workers in hospice is also discussed.
6.Progress in the study of Her2-targeted cancer therapeutic antibodies.
Liang CHANG ; Chen-hui LI ; Jian GAO
Acta Pharmaceutica Sinica 2015;50(5):516-520
Tumor surface antigen human epidermal growth factor receptor 2 (Her2) is a type I receptor tyrosine kinase, which belongs to human epidermal growth factor receptor family. Her2-overexpression is associated with tumorigenesis and metastasis. Due to significant clinical effects, Her2-targeted cancer therapy especially therapeutic antibody has become the hot spot in the field of cancer treatment. Anti-Her2 antibody drugs include monoclonal antibodies, antibody-drug conjugates, bispecific antibodies and emerging "two in one" antibody. Based on structure and function of Her2, this review focuses on recent advances in active mechanisms and clinical researches of these antibodies.
Antibodies, Bispecific
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therapeutic use
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Antibodies, Monoclonal
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therapeutic use
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Humans
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Immunoconjugates
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therapeutic use
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Neoplasms
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drug therapy
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Receptor, ErbB-2
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immunology
7.The function of Th1/Th2 cells in children with acute Kawasaki disease.
Jian CHANG ; Ji-rong LU ; Dong LIANG
Chinese Journal of Pediatrics 2006;44(5):377-378
Acute Disease
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Case-Control Studies
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Child
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Child, Preschool
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Female
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GATA3 Transcription Factor
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genetics
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Humans
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Infant
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Interferon-gamma
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genetics
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Interleukin-4
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genetics
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Male
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Mucocutaneous Lymph Node Syndrome
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blood
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genetics
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immunology
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RNA, Messenger
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Reverse Transcriptase Polymerase Chain Reaction
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T-Box Domain Proteins
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genetics
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Th1 Cells
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immunology
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Th2 Cells
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immunology
8.Role of Video-assisted Thoracic Surgery in management of Penetrating Thoracoabdominal Injuries
Jian ZHANG ; Liang YU ; Hao CHANG
Chinese Journal of Minimally Invasive Surgery 2005;0(07):-
Objective To evaluate the value of video-assisted thoracic surgery(VATS)for penetrating thoracoabdominal injuries.Methods Under general anaesthesia and double-lumen tracheal intubation,VATS was carried out to examine patients with chest injuries.Those who had mild injuries received VATS combined with mini-incision surgery.Electrocoagulation or suturing was employed to control intraoperative bleeding,and then blood clots were removed.Injured diaphragm muscles were repaired,and organs with hemorrhage or ruptures were sutured or resected.The seriously injured cases underwent open surgery and intra-abdominal exploration instead.Results A total of 18 patients received the operations.Among them,15 patients underwent VATS combined with mini-incision surgery(repair of the diaphragm was performed on 15,controlling intercostal arterial bleeding on 8,repair of the lung on 2,wedge resection of the lung on 2,and coagulated hemothorax removal on 2),the other 3 were converted to open surgery for repairing the diaphragm(3),heart(1),or esophagus(1),or lobectomy(2).Abdominal surgery via the thorax were performed on 13 cases,including repair of the liver in 1,lienectomy in 1,gastrorrhaphy in 1,repair of diaphragmatic hernia in 3,and intra-abdominal exploration in 7.Five patients received open surgery(pancreatic neoplasty in 1,repair of the liver in 1,lienectomy in 1,gastrorrhaphy in 2,and repair of the caul and mesenterium in 3).One patient who had multi-organ penetrating injuries died of hemorrhagic shock,circulatory failure,and DIC after open thoracic and abdominal surgeries.The mean operation time in this series was(125?44)minutes(ranged from 45 to 220),and the mean blood loss was(1089?582)ml(500 to 10 000 ml).Twenty-four hours after the operation,the mean volume of chest drainage was(234?75)ml(100 to 350 ml)in the first 24 hours after the operation.The chest drainage tube was withdrawn 2.5(2 to 5)days postoperation.The patients expelled gas in 1 to 4 days(mean,2 days).Totally,12 patients were followed up for 3 to 12 months(mean,6 months),during which none of them had trauma-related complications.Conclusion VATS combined with mini-incision surgery is safe and effective for patients with thoracoabdominal injuries,if the cases were carefully selected.
9.Thoracoscopic Loop Ligation for Spontaneous Pneumothorax:Report of 90 Cases
Hao CHANG ; Ju WANG ; Jian ZHANG
Chinese Journal of Minimally Invasive Surgery 2005;0(08):-
Objective To evaluate the efficacy of video-assisted thoracoscopic surgery for loop ligation in patients with spontaneous pneumothorax.Methods From April 2004 to December 2006,90 consecutive cases of spontaneous pneumothorax were subjected to video-assisted thoracoscopic surgeries for loop ligation in our department.The pulmonary bullae of the patients(
10.Advance in Tongue Pressure Measurement during Swallowing (review)
Hong CHANG ; Shuqin XIAO ; Jian WU
Chinese Journal of Rehabilitation Theory and Practice 2014;(2):156-158
The measurement of pressure between tongue and the hard palate during swallowing is an evaluation method which is noninvasive and accurately quantitative. This article reviewed the measurement of tongue pressure, the changes of pressure in different poses,bolus types and people, as well as the prediction of dysphagia according to tongue pressure.