No abstract available.
Indocyanine Green* ; Skin*

No abstract available.
Hydrothorax* ; Indocyanine Green*

BACKGROUND: The indocyanine green (ICG) finger monitoring method is a newly developed noninvasive method for the ICG clearance test. This study was performed to determine its clinical usefulness compared with the conventional blood sampling method. METHODS: The ICG clearance test was performed on 270 patients using both the conventional blood sampling method and the finger monitoring method simultaneously. The plasma disappearance rate of the ICG and the 15-minute retention ratio (ICG R15) were analyzed and compared with the conventional blood sampling method. RESULTS: The plasma disappearance rate using the finger monitoring method was slightly lower than that of the conventional blood sampling method with good correlation (r=0.840, P<0.001). ICG R15 using finger monitoring method was slightly higher than that of the conventional blood sampling method with good correlation (r=0.839, P<0.001). CONCLUSIONS: As there was a good correlation between the conventional blood sampling method and the finger monitoring method, the latter method seemed to be clinically useful due to its convenience and accuracy.
Fingers* ; Humans ; Indocyanine Green* ; Plasma

Humans ; Indocyanine Green ; Liver Cirrhosis ; Liver Failure

Indocyanine green (ICG) is the most commonly used near-infrared fluorescent (NIRF) dye in clinical practice, and its mediated near-infrared fluorescence imaging technology is gradually applied in clinical practice. It has shown great potential in invasive surgery (MIS) and is expected to become the standard technology for surgical diagnosis and treatment of diseases. The clinical application of ICG fluorescence laparoscopy is reviewed here.
Indocyanine Green ; Fluorescence ; Laparoscopy ; Coloring Agents

We examined three patients with multiple evanescent white dot syndrome(MEWDS) using confocal laser scanning indocyanine green angiography(ICGA), and observed two types of hypofluorescent lesion which were very characteristic and diagnostic by themselves. One was dot pattern, dense hypofluorescences which were detected evidently in the late phases, and some of them could be confirmed in the early phases. They clustered in the peripapillary area and dispersed sporadically to the midperiphery. The other was circular pattern, relatively lighter hypofluorescences which were evidently observed in the late phases also. They were crowded and fused in the peripapillary area or in the posterior pole and scattered to the midperiphery in a radiating pattern. These area included clinically observed white dot lesions, but were more widespread distinctively. At the recovery stages, all these hypofluorescent lesions disappeared completely. It is supposed that the former represents blocked fluorescence by inflammatory precipitates and the latter reveals circulatory disturbance in the choriocapillary or pre-capillary arteriole. Previous fluorescein angiographic and electrophysiologic studies have demonstrated the involvement of the retinal pigment epithelium(RPE) and photoreceptors in MEWDS. Our findings on ICGA suggest that the ischemic choroidal circulatory disturbance due to the inflammatory precipitates in the choroid may be the primary change and the RPE and photoreceptors may be involved secondarily.
Arterioles ; Choroid ; Fluorescein ; Fluorescence ; Humans ; Indocyanine Green* ; Retinaldehyde

PURPOSE: To evaluate whether the branching vascular network component of polypoidal choroidal vasculopathy (PCV) could be occluded after photodynamic therapy (PDT). METHODS: A retrospective clinical study based upon indocyanine green angiogram was performed in 26 eyes of 26 patients having PCV and treated with PDT. RESULTS: Of the 19 eyes which received a single session of PDT, none showed complete occlusion of the vascular network and 16 (84%) showed, at least in part, a persisting vascular network. Of the 7 eyes which had two session of PDT, 1 (14%) showed complete occlusion of the vascular network, and 3 (43%) showed, at least in part, a persisting vascular network. Changes in the vascular network could not be evaluated with exactness in 6 eyes. Of the 18 eyes achieving clinical improvement after single PDT, 3 had recurrence of hemorrhagic or exudative changes from new polypoidal lesions which originated from the persisting vascular network. CONCLUSIONS: It is difficult to expect complete occlusion of branching vascular network after PDT, which means future recurrence may not be prevented even though occlusion of polyps accompanied with clinical improvement can be achieved with PDT.
Choroid* ; Humans ; Indocyanine Green ; Photochemotherapy* ; Polyps ; Recurrence ; Retrospective Studies

PURPOSE: The authors used a mixture of ICG dye and viscoelastic material to perform continuous curvilinear capsulorhexis (CCC) in white cataract, in order to stain the anterior capsule with the minimal contact with the corneal endothelial cells. METHODS: In 10 eyes with white cataract, CCC was performed under the anterior capsular staining with ICG dye. The ICG solution was prepared by dissolving 25 mg of ICG in 1 mlof an aqueous solvent, which was mixed in 3 ml of balanced salt solution. With a three-way connector, one way was occluded, the other was connected with 1 ml of viscoelastic material, and the third was connected with 4 ml of the prepared ICG solution. One half percent mixture of ICG and viscoelastic material was made by alternate injection. The anterior chamber was filled with viscoelastic material, and then the anterior capsule was stained by slow spread of the prepared ICG mixture between anterior capsule and viscoelastic material. The remains of ICG mixture was removed by infusion and aspiration. The anterior chamber was filled with viscoelastic material again, CCC was performed with cystotome. Corneal edema and anterior chamber reaction was evaluated with slit lamp at 1 day, 1 week and 1 month after surgery. RESULTS: In all cases, CCC was successfully completed under the anterior capsular staining of the desired area with 0.5% ICG dye mixture and there was no contact with the corneal endothelial cells. Mild corneal edema and mild anterior chamber reaction that observed on the 1st postoperative day subsided within 1 week in all cases. CONCLUSIONS: Staining the anterior capsule with 0.5% ICG dye mixture, after the anterior chamber was filled with viscoelastic material, it was helpful to perform CCC in white cataract. Using this technique, we could minimize the contact with the corneal endothelial cells and stain the desired area.
Anterior Chamber ; Capsulorhexis ; Cataract ; Corneal Edema ; Endothelial Cells ; Indocyanine Green*

PURPOSE: To compare the outcomes of indocyanine green (ICG) and triamcinolone (TA) assisted internal limiting membrane (ILM) peeling during idiopathic macular hole surgery. METHODS: Fifty-four eyes of 54 patients with idiopathic macular hole underwent pars plana vitrectomy including peeling of the posterior cortical hyaloid and peeling of the internal limiting membrane. For enhanced visualization of ILM, ICG was used in 25 eyes and TA in the remaining 29 eyes. Postoperative visual acuity was measured and OCT was performed. RESULTS: Anatomical closure was achieved in 25 eyes (100%) in ICG group and 28 eyes (97%) in TA group, Best corrected visual acuity improvement by > or =2 lines was in 15 eyes (60%) in ICG group and 18 eyes (62%) in TA group. Postoperative visual improvement rates by > or =20/50 were 10 eyes (40%) in ICG group and 9 eyes (31%) in TA group. CONCLUSIONS: Peeling of the internal limiting membrane using triamcinolone and indocyanine green was safe and effective for anatomic and functional success in idiopathic macular hole surgery. Further studies of the toxicity of TA, ICG and the result of internal limiting membrane peeling is needed.
Humans ; Indocyanine Green* ; Membranes ; Retinal Perforations* ; Triamcinolone* ; Visual Acuity ; Vitrectomy

PURPOSE: We observed many cases which showed hypofluorescent spots in indocyanine green angiography (ICGA) at the late phase as well as white dot syndrome, so we analyzed for types and causes of these. METHODS: we analyzed the color photographs, fluorescein angiographs (FAG) and ICGA of the 21 patients (39 eyes) who have noted hypofluorescent spots at the late phase retrospectively. RESULTS: The hypofluorescent spots in ICGA could be classified into two types. The first is that which seen hypofluorescence from the early phase and clearly to the late phase and the second, relatively lighter dark spots which appeared after midphase and is seen in the late phase. But when we analyze these together with ophthalmologic findings and FAG, we found out that the lesion could not be found in the retina and FAG or that it is noted as hyperfluorescence or hypofluorescence in the early and late phase of FAG. So the causes were thought to be variable. CONCLUSIONS: We could find hypofluorescent spots in the late phase of ICGA in the lesions which were classified as white dot syndrome in the past as well as presented normal finding in the retina and FAG and they had variable morphologies and causes.
Angiography* ; Fluorescein ; Humans ; Indocyanine Green* ; Retina ; Retrospective Studies