Combined Modality Therapy ; Disease Progression ; Gastrointestinal Neoplasms ; diagnosis ; therapy ; Humans ; Physicians ; psychology

Haemorrhagic cystitis (HC) is a potentially severe complication,caused by high-dose chemotherapeutic drugs or radiation therapy (RT).It is thought that a defect caused by chemotherapeutic drugs in the glycosaminoglycan (GAG) layer may be the first step in HC development.The pathogenesis of RT-induced cystitis originates as a progressive obliteration of the small blood vessels of the bladder wall.Mesna,hyperhydration and continuous bladder irrigation have been shown effective in preventing HC.However,these preventive protocols do not always satisfactorily protect the patient from bladder injury.In recent years,GAG-replenishment therapy and hyperbaric oxygen therapy have gained some evidence exists.Currently,there is a lack of consensus about the best treatment for patients with chemotherapy and radiatherapy induced HC.Therefore,the prevention and treatment of this complication is still the focus at present.

Background and purpose:It is rare that gastric and colorectal cancer metastasize to the uterine cervix.The study aimed to explore the treatment,prognosis,and the clinical features of metastatases of uterine cervix from gastric and colorectal cancer.Methods:22 patients with metastatic carcinoma to the uterine cervix from gastric and colorectal cancer were treated from 1994 to 2007 in Cancer Hospital of Zhejiang Province.The clinical pathologic parameters and prognosis were analyzed retrospectively.Results:The ages of patients ranged from 29 to 74 years old with mean of 46.7 years.The main symptom of patients was vaginal bleeding(54.5%).The primary tumor was gastric cancer in 10 cases and colorectal cancer in 12 cases.6 cases received operation alone,3 cases received radiotherapy alone,1 case received chemotherapy alone,9 cases were treated by the combination of chemotherapy,operation or radiotherapy,3 cases were not treated.According to clinical pathologic parameters,if the primary tumor was gastric cancer,it metastasesed to endometrium of uterine body;if the primary tumor was colorectal cancer,the serosa and myometrial of uterine body were invaded.In 22 cases,3 cases were still under treatment,with one lost follow-up,and the others died,the mean overall survival was 14.6 months.The mean overall survival were 11.2 months for gastric cancer and 17.9 months for colorectal cancer respectively.The mean overall survival of signet-ring cell carcinoma,mucinous adenocarcinoma and adenocarcinoma(G1-G3)were 10 months,13 months,and 18.1 months respectively.The mean overall survival for the patients treated by either radiotherapy,operation or the combination were 10.7 months,13.2 months and 17.7 months respectively.The mean overall survival for 4 patients treated by radical operation and 5 patients treated by tumor cell reduction-extinction technique were 22.3 months and 7.8 months respectively.Conclusion:The mean overall survival for the patients with metastases of uterine cervix from gastric cancer was worse than that from colorectal cancer.The patients with signet-ring cell carcinoma had the shortest mean overall survival,followed by mucinous adenocarcinoma.The primary lesion of tumor,histological types and treatment modality may be the main factors that affect the prognosis.The strategy of the treatment for the disease should be multidisciplinary therapy including surgery,radiotherapy and chemotherapy.

Objective With the extensive application of vacuum sealing drainage (VSD),vacuum control mode needs to be developed and improved.The aim of this study was to develop ARM-based VSD system.Methods The system was composed of central processing unit,pressure sensing unit and pressure control units.32-bit LJD-e Win7000 was used as central processing unit.X-type silicon pressure sensor was used to sense the pressure.Real time feedback technology was applied to control the solenoid opening and closing in order to accurately control the negative pressure.Results VSD pressure control system was completed.Compared with the measured value,the system had relatively large error in low pressure.With the increase of pressure,the error decreased.Conclusion Through linear correction algorithm,the pressure control system can meet the requirements of VSD machine.

Objective To study the cause of blurred vision or cecitas after cardiac or cerebral angiography. Methods Six patients including 4 performed with cerebral angiography and 2 with cardiac angiography were analyzed. Results In those 6 patients, blurred vision happened in 4 cases, and cecitas appeared in 2 cases. Ophthalmologic examination revealed bilateral isocoria, thinning ophthalmic arteries and normal light reflex. Color Doppler flow imaging showed clearly the central retinal arteries. No cerebral infarction and brain hemorrhage were detected under CT. Conclusions Blurred vision and cecitas are the rare complications occurred with cardiac or cerebral angiography, probably with direct relationship to the concentration or dosage of the contrast media used, and the primary diseases of the patients.

Acupuncture Therapy ; Drugs, Chinese Herbal ; pharmacology ; Female ; Humans ; Ovulation ; drug effects ; Ovulation Induction

Breast Neoplasms ; diagnosis ; therapy ; Female ; Humans

Humans ; Rectal Neoplasms ; diagnosis ; therapy

Objective: To analyze the recombination of full-length genomic sequences of novel influenza virus A/H1N1 in 2009 pandemic. Methods: The full-length sequences of the novel A/H1N1 and reference sequences were downloaded from NCBI database. MEGA4.0 software was used to connect, align sequences, and analyze the similarity between the full-length sequences of the novel virus and each of the reference strains. Recombination was analyzed by Simplot software (version 3.5.1). Results: Simplot analysis indicated that the PB1 genes (polymerase B1, PB1) of the novel A/H1N1 viruses might evolve from human H3N2 virus (identity: 93.7%); the PB2 genes (polymerase B2, PB2) and the PA genes (polymerase A, PA) might evolve from avian H5N1 viruses (identity: 89.0%, 89.9%, respectively); the HA genes (hemagglutinin, HA), the NP genes (nucleoprotein, NP) and the NS genes (non-structural protein, NS) showed high similarities with those of swine H1N1 viruses isolated in North America (identity: 91.7%, 93.1%, and 93.1%, respectively); and the NA genes (neuraminidase, NA) and the MP genes (matrix protein, MP) might evolve from European swine H1N1 viruses (identity: 90.5%, 95.5%, respectively). The full-length sequence of the novel A/H1N1 viruses had a highest similarities with swine H1N1 viruses isolated in North America (identity: 83.9%). Conclusion: The novel influenza virus A/H1N1 is a recombinant virus evolving from human H3N2 viruses, swine H1N1 from North America, swine H1N1 from Europe, and swine H5N1 from Asia.

Objective: To investigate the role of HBV subgenotypes B2, C2 in the carcinogenesis, treatment and prognosis of hepatocellular carcinoma (HCC). Methods: HBV genotypes and subgenotypes were detected in 462 HCC patients and 234 chronic hepatitis B (CHB) patients by a multiplex PCR assay, and HCC patients infected with HBV B2 or C2 were followed up for a year after surgical resection, transarterial chemoembolization(TACE) or a combination of both. Results: The HCC patients infected with HBV C2 had a higher chance to receive surgical treatment than those with B2 (P=0.007). Age of 40 years or older (P=0.030), male gender (P= 0.000), and viral load (>10 000 copies/ml) (P=0.017) were the independent risk factors for the carcinoge-nesis of HCC by using multivariate logistic analysis; however, there was no significant difference in the carcinogenesis of HCC between CHB patients with HBV subgenotypes B2 and C2. Age of 50 years or younger (P=0.044), infection with HBV B2 (P=0.027), and non-surgical treatment (P=0.000) were the independent risk factors for the recurrence of HCC. Thick trabecular type was more prevalent in HCC patients infected with HBV B2, C2 and genotype mixture (85.7%, 71.2% and 75.0%, respectively), and the proportions of histopathological types were not significantly different between HCC patients infected with HBV B2, C2 and genotype mixture. HBV subgenotype C2 was found in all HCC patients with rare histopathological type and subgenotype B2 and mixture were no found. Conclusion: There is no significant difference in the carcinogenesis of HCC between CHB patients with HBV subgenotypes B2 and C2. The HCC patients infected with HBV B2 have a lower chance to receive surgical treatment and are more severe than those with C2. HBV B2 is also closely associated with recurrence of HCC.