1.Survey of emergency response capacity of health authorities in Shandong province
Bin GUO ; Lu WANG ; Lingzhong XU ; Qiongwei HU ; Heng WANG
Chinese Journal of Hospital Administration 2015;(5):381-383
Objective To learn the emergency response capacity of health authorities at city level in Shandong province in order to discover loopholes and make improvement. Methods The health emergency questionnaire designed by China Health and Family Planning Commission was used for survey of 1 7 city-level health authorities in Shandong province.Results 52.94% of the health authorities were found with health emergency reserve funding; 100.00% of them with public health emergency contingency plans;94.12% of them having health emergency supplies in kind;100.00% of them having health emergency training for all of the staff;100.00% of them with direct web reporting for public health emergency.Conclusion Such authorities were found with satisfactory health emergency capacity in general.Defects were found with emergency funding shortage,poor training and drilling outcomes, poor material reserves management,and insufficient health emergency personnel.
2.Association of lipoprotein lipase gene Hind Ⅲ and S447X polymorphisms with metabolic syndrome in Kazakh of Xinjiang
Zhiming YANG ; Shuxia GUO ; Jingyu ZHANG ; Heng GUO ; Rulin MA ; Shangzhi XU ; Dongsheng RUI
Chinese Journal of Endocrinology and Metabolism 2010;26(7):555-559
Objective To investigate the association of lipoprotein lipase gene Hind Ⅲ and S447X polymorphisms with metabolic syndrome. Methods PCR-RFLP was used to detect lipoprotein lipase Hind Ⅲ and S447X genotypes in 401 subjects(including 201 controls, 200 metabolic syndrome patients). Results ( 1 ) The levels of waist circumference ( WC ) , hip circumference ( HC ) , waist-to-hip ratio ( WHR ) , body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure ( DBP) , total cholesterol ( TC) , triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and fasting plasma glucose (FPG) were significantly different between metabolic syndrome group and control group (all P< 0.05). (2)The frequencies of H+H+ genotype,H+allele,SS genotype, and S allele for metabolic syndrome were all significantly higher than those for controls( H+H+ genotype:66. 5% vs 54.2% ,P=0.012; H+ allele:78.0% vs 71.4%, P=0.031;SS genotype:89.5% vs 77. 1% , P = 0.001; Sallel:94.5% vs 87. 56% , P = 0.001). (3) The levels of WC, HC, WHR, BMI, SBP, DBP, TG, LDL-C, and FPG in H + H-/H-H- genotype were significantly lower than those in H+H+ genotype, HDL-C was significantly higher than that in H+H+ genotype ( all P<0. 05). The levels of WC, HC, WHR, BMI, SBP, DBP, TC, TG, and FPG in SX/XX genotype were significantly lower than those in SS genotype, HDL-C was significantly higher than that in SS genotype ( all P< 0.05). (4)Multi-way logistic regression analysis suggested that risk factors for metabolic syndrome were smoking, drinking, and SS genotype (OR value was 4.289,2.268, and 2. 597, respectively ). (5) Result of interaction analysis among different factors indicated that the risk for metabolic syndrome in smoker with SS genotype was 3. 996 times of non-smokers with SX/XX genotype. Conclusions The lipoprotein lipase gene S447X polymorphism is associated with metabolic syndrome risk in Kazakh, and SS genotype and S allele may serve as genetic risk factors of metabolic syndrome, H + H-/H-H- and SX/XX genotypes yield beneficial effect for lipid and blood pressure. SS genotype and smoking may exist additive effect.
3.Study on the optimal waist circumference cut-off points of metabolic syndrome in Kazakh
Heng GUO ; Jingyu ZHANG ; Rulin MA ; Dongsheng RUI ; Shangzhi XU ; Fen SUN ; Shuxia GUO
Chinese Journal of Endocrinology and Metabolism 2011;27(1):40-42
Questionnaire-based survey, physical examination, and blood testing were conducted according to cluster random samplings in Kazakh residents in Xinjiang.2 760 samples were collected to analyze the association of different strata of waist circumference and clustering of metabolic syndrome (MS) components.Accoding to International Diabetes Federation standard, the prevalence of ≥1and ≥2 components of MS showed increasing trend with the increase of waist circunference, and odds ratio of clustering of MS components also increased significantly.The distance of receiver operating characteristic curve was the shortest and the prevalence of MS was 22.1% ;22.4% in men, and 21.9% in women;when the waist circumference was ≥91 cm for men, and ≥88 cm for women.
4.Entry of antibiotic ointment into the anterior chamber following sutureless clear corneal incisions phacoemulsification:a case report
Sheng-Li, HAO ; Zhi-Heng, LIU ; Zhi-Guo, GAO ; Guo-Zhi, XU
International Eye Science 2011;11(8):1318-1320
·AIM:To report a case of entry of antibiotic ointment into the anterior chamber following sutureless clear corneal incisions phacoemulsification.·METHODS:A 62-year-old man had uneventful phaco-emulsification with clear corneal incisions with intraocular lens(IOL) implantation. Postoperative medication included antibiotic/steroid ointment; the eye was firmly patched at the end of the procedure. On the first postoperative day, the patient was seen an oily droplet floating in the anterior chamber. Immediate surgical removal of the ointment without IOL exchange was performed.·RESULTS:During follow-up for six months after irrigation/aspiration of the anterior chamber and removal of the oily droplet, visual acuity and intraocular pressure (IOP) were unchanged and anterior segment was formed and quiet.·CONCLUSION:Ophthalmic ointment may ingress into the anterior chamber through unstable clear corneal incisions. The case highlights the importance of appropriate wound construction and integrity, as well as the risk of tight eye patching following placement of ointment.
5.Signaling pathways in pathogenesis of diffuse large B-cell lymphoma.
Fen ZHANG ; Fang-Ping XU ; Yan-Hui LIU ; Heng-Guo ZHUANG
Chinese Journal of Pathology 2011;40(4):282-285
Apoptosis
;
Fas Ligand Protein
;
metabolism
;
Germinal Center
;
pathology
;
Humans
;
Janus Kinases
;
metabolism
;
Lymphoma, Large B-Cell, Diffuse
;
etiology
;
genetics
;
metabolism
;
pathology
;
NF-kappa B
;
metabolism
;
Positive Regulatory Domain I-Binding Factor 1
;
Proto-Oncogene Proteins c-bcl-6
;
genetics
;
metabolism
;
Repressor Proteins
;
metabolism
;
STAT3 Transcription Factor
;
metabolism
;
Signal Transduction
;
Translocation, Genetic
;
fas Receptor
;
metabolism
6.Antigen retrieval for immunohistochemistry performed on destained paraffin sections.
Xin-lan LUO ; Jie XU ; Yan-hui LIU ; Heng-guo ZHUANG
Chinese Journal of Pathology 2007;36(1):59-60
Antigens
;
analysis
;
immunology
;
Antigens, CD
;
analysis
;
immunology
;
Formaldehyde
;
Hot Temperature
;
Humans
;
Immunohistochemistry
;
methods
;
Neoplasms
;
metabolism
;
pathology
;
Paraffin Embedding
;
methods
;
Staining and Labeling
;
Tissue Fixation
;
methods
7.Function and mechanism of tumor suppressor gene FBW7 in tumorigenesis.
Hui-jie HUANG ; Fang ZHENG ; Fang-ping XU ; Yan-hui LIU ; Heng-guo ZHUANG
Chinese Journal of Pathology 2013;42(3):214-216
Animals
;
Carcinogenesis
;
Cell Cycle Proteins
;
genetics
;
metabolism
;
Cyclin E
;
metabolism
;
F-Box Proteins
;
genetics
;
metabolism
;
F-Box-WD Repeat-Containing Protein 7
;
Gene Silencing
;
Genes, Tumor Suppressor
;
Humans
;
Mutation
;
Myeloid Cell Leukemia Sequence 1 Protein
;
metabolism
;
Neoplasms
;
genetics
;
metabolism
;
pathology
;
Proto-Oncogene Proteins c-myc
;
metabolism
;
Receptors, Notch
;
metabolism
;
Signal Transduction
;
TOR Serine-Threonine Kinases
;
metabolism
;
Ubiquitin-Protein Ligases
;
genetics
;
metabolism
8.Effects of pH9.0 Tris-EDTA and pH6.0 citrate on antigen retrieval.
Xin-Lan LUO ; Yan-Hui LIU ; Heng-Guo ZHUANG ; Xiu-Ling CAI ; Jie XU
Chinese Journal of Pathology 2005;34(11):749-751
Antigens
;
analysis
;
Cervical Intraepithelial Neoplasia
;
metabolism
;
Citric Acid
;
Cyclin-Dependent Kinase Inhibitor p21
;
analysis
;
Edetic Acid
;
Formaldehyde
;
Hot Temperature
;
Humans
;
Hydrogen-Ion Concentration
;
Immunohistochemistry
;
Intestinal Mucosa
;
immunology
;
Ki-67 Antigen
;
analysis
;
Microwaves
;
Palatine Tonsil
;
metabolism
;
Proto-Oncogene Proteins c-bcl-6
;
analysis
9.Genetic classification of adenocarcinoma of lung.
Fang-Ping XU ; Yan-Hui LIU ; Heng-Guo ZHUANG
Chinese Journal of Pathology 2008;37(3):190-192
Adenocarcinoma
;
classification
;
genetics
;
pathology
;
Forecasting
;
Humans
;
Lung
;
pathology
;
Lung Neoplasms
;
classification
;
genetics
;
pathology
10.Angioimmunoblastic T cell lymphoma with Reed-Sternberg-like cells.
Yan-hui LIU ; Heng-guo ZHUANG ; Dong-lan LUO ; Xin-lan LUO ; Jie XU
Chinese Journal of Pathology 2006;35(4):249-250
Aged
;
Antigens, CD20
;
analysis
;
Gene Rearrangement
;
Humans
;
Immunoblastic Lymphadenopathy
;
genetics
;
metabolism
;
pathology
;
Immunoglobulin Heavy Chains
;
genetics
;
Immunohistochemistry
;
Lymph Nodes
;
metabolism
;
pathology
;
Lymphoma, T-Cell
;
genetics
;
metabolism
;
pathology
;
Male
;
Polymerase Chain Reaction
;
RNA, Viral
;
analysis
;
Receptors, Antigen, T-Cell, gamma-delta
;
genetics
;
Reed-Sternberg Cells
;
metabolism
;
pathology