Advanced non-small cell lung cancer(NSCLC)accounts for all NSCLC 45% . In recent years,chemotherapy combined with radiotherapy has become a new standard for NSCLC. On NSCLC radiothera-py and chemotherapy(CRCT),radiation total dose,fractionation method,different chemotherapy combined with radiotherapy have many details in the efficiency and toxicity tolerance,which are still in the exploration.

Objective: The effects of two fat substitutes, sucrose polyester(SPE) and triglyceride of short fatty acids(TRIS)on lipid metabolism in rats were studied. Methods: Diets containing either SPE or TRIS were fed to rats for 30d. Male Wistar rats were allowed free access to one of three diets: a control diet containing 20% corn oil, SPE group diet containing 10% SPE and 10% corn oil, TRIS group diet containing 20% TRIS. Plasma glucose, TG, TC, HDL C, LDL C, ApoA I, ApoB were analysed. Results: Dietary fat substitutes lowered total energy consumption and body weight 8.1%?4.1%and 12.3% ?16.0% respectively. Two fat substitutes lowered plasma glucose, TG, TC, LDL C, VLDL C, ApoB level and increased HDL C and ApoA I level. TRIS could decrease TC/HDL C, LDL C/HDL C, ApoB/ApoA I more significantly than SPE. Conclusion: TRIS and SPE have the potential benefits on lipid metabolism and energy intake control in rats, TRIS is more efficient than SPE.

Phyllosphere and epiphytes have attracted significant interest of more and more researchers by their unique biological characteristics. Progress of research on phyllosphere and epiphytes was summarized in this paper, and the special emphasis was put on the characteristic of phyllosphere, microbial communities, invasion and the location of bacteria on leaf surfaces. Some ideas for further studies on phyllosphere microbes were also proposed.

Objective To observe the effect of new moist dressings on pressure ulcers after spinal cord injury. Methods 58 spinal cord injured patients complicated with pressure ulcers were divided into observation group (n=29) and control group (n=29). The observation group accepted moist dressings, while the control group accepted routine dry dressings, TDP and ultraviolet irradiation. The incidence of im provement were recorded 2 weeks after treatment, and the time of healing were compared. Results 11 cases cured, 17 cases relieved in the observation group, and it was 5 and 18 cases in the control group, respectively (P<0.05). It spent (26.69±16.48) days to cure in the observa tion group, and (38.24±22.47) days in the control group (P<0.05). Conclusion The moist therapy may promote the cure of pressure ulcers af ter spinal cord injury, and shorten the time of cure.

Interferon ( IFN) plays an essential role in antiviral infection.Interferons are divided into different categories according to their structure and function.People have attached increasing importance to TypeⅠinterferon( IFN-Ⅰ) in light of its unusual antiviral mechanism.This review is intended to shed light on IFN-Ⅰ,including its antiviral function,signal pathway and regulation.

Consumer Product Safety ; legislation & jurisprudence ; Legislation, Food

Objective To study the effects of activation and inhibition agents of protein kinase C on the function and expression of P glycoprotein in drug resistant gastric cancer cells. Methods Immunohistochemical staining and FACS were used to determine the expression of P glycoprotein on drug resistant gastric cancer cells SGC7901/VCR and its parent cells SGC7901, which were treated or not treated by activation or inhibition agents of protein kinase C(PMA or H 7). Double labeled immunoflurescent and laser scan confocal microscopy were used to detect the coexpression of protein kinase C ? and P glycoprotein on drug resistant gastric cancer cells. Rohdamin 123 was used as fluorescent probe to observe the effects of PMA and H 7 on the function of P glycoprotein and drug accumulation in SGC7901/VCR. Results P glycoprotein had positive staining on SGC7901 cells and much stronger staining on SGC7901/VCR cells. Protein kinase C ? and P glycoprotein exhibited coexpression on SGC7901 cells and much higher coexpression level on SGC7901/VCR cells. When treated by PMA, SGC7901/VCR cells showed time dependent decreasing of drug accumulation, enhancing function and decreasing expression of P glycoprotein. When treated by H 7, SGC7901/VCR cells showed time dependent increasing of drug accumulation, weakening function and increasing expression of P glycoprotein.Conclusion Protein kinase C may play a role in multidrug resistance of gastric cancer cells via modulating the expression and function of P glycoprotein.

Objective To evaluate the expression of autoantibodies to cell membrane associated with DNA (mDNA) in systemic lupus erythematosus (SLE).The specificity of these antibodies differs from antibodies to double stranded DNA.Method Using indirect immunofluorescence,serum samples were detected giving a characteristic pattern of peripheral membrane fluorescence on cultured HL60.Results This pattern was observed in 81 of 90 serum samplas of SLE patients,but absent in the serum samples of 35 rheumatoid arthritis,31 ankylosing spondylarthritis and 42 blood donors.In 20 Sjgren syndrome′s patients only one showed a positive test.Conclusion This novel rapid immunofluorescence method may serve as an identification test of SLE patients.Due to the sensitivity (90%) and specificity (98 8%),it is better than the other diagnostic tests such as the detection of antibodies to dsDNA and Sm.