Congenital heart disease is the most common birth defect.With the significant improvements of cardiac surgical techniques,the survival of newborns and infants with complex congenital heart disease(CHD) has obviously been increased.However,neurological sequelae are still common and up to 25 ％ ～50％.The most important lesion after CHD surgery is white matter(WM) injury.Recent studies show that periventricular leukomalacia disease characterized by WM injury is common in C-HD infants especially after cardiac surgery.It is previously thought to be due to the cardiopulmonary bypass and surgical operation.However,with the advances in surgery and medical diagnostic technology and development of basic research in recent years,it is discovered that WM injury in infants with CHD is a complex lesion influenced by preoperative,operating and postoperative factors.The movement disorders and the defects of attention,learning and other aspects in the late growth of these children bring a huge economic burden to the family and society,reducing the quality of the population.Therefore,exploring etiology,mechanisms and control methods of WM injury in infants with CHD becomes a hot topic in recent years,and it may also become an important direction for future research,aiming to the significant improvements in CHD children with neurodevelopmental damages.

Objective To study the clinical effect on C-IBS treated with tegaserod and bifico combined. Methods 156 patients were randomly divided into one therapy group (group A) and two control group (group B, group C). Patients in the group A were given tegaserod and bifico therapy, while those in group B were given tegaserod therapy and group C were given bifico therapy. Results After 4 weeks' clinical treatment, the rates of remission were 94.6% in group A,7 9.1 % in group B and 54.2% in group C. There were significant statistical differences among three groups(P

Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; etiology ; Occupational Diseases ; etiology

AIM: To study the effects of chromium rutin synthesized with rutin and chromium (Ⅲ) on metabolism of blood lipid. METHODS: The effects of chromium rutin on metabolism of blood lipid were evaluated by the changes of triglyceride, cholesterol, HDL cholesterol, and LDL cholesterol in normal rats and the rats with high blood lipid. RESULTS: Chromium rutin could increase the blood chromium, decrease the concentrations of triglyceride, cholesterlo and LDL cholestelol,and increase the concentration of HDL cholesterol in normal and the rats with high blood lipid rats. CONCLUSION: Chromium rutin has an effect on the blood lipid in rats.

Cryptococcus neoformans(CN) is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system,resulting in devastating meningitis.The management of cryptococcal meningitis remains challenging because of its high mortality,the toxicity and uncertainty effect of antifungal therapy.In recent years,the study of the mechanism of neurotropism of CN has made a great progress.Many violence factors of this pathogen and several signal pathways of the host involved in this process have been discovered.Combination therapy with immunotherapy to regular antifungal treatment has become an important adjuvant method.The present review will concisely present current progress of pathogenesis and immunotherapy of cryptococcal meningitis.

Objective To investigate the role of endoplasmic reticulum stress ( ERS) in asbestos-induced Alveolar epithelial cell apoptosis.Methods A549 cells were treated with asbestos to observe the expression of ERS proteins and apop-tosis gene by immunofluorescence staining and western blotting.Results Under asbestos exposure, the expression of Bip, GRP94, IRE-1α, BAX and BAK are up-regulated.There is a positive correlativity of the expression of proteins to the ex-posure time of asbestos.Conclusion Endoplasmic reticulum stress takes part in asbestos-induced apoptosis.

Objective To explore the effect of dexmedetomidine on upper limb surgery during brachial plexus block anesthesia and its influence on cognitive function.MethodsFrom May 2015 to May 2016, 60 cases of elbow joint operation patients were studied.The patients were randomly divided into control group (local anesthesia combined with physiological saline) and observation group (using local anesthesia drugs with dexmedetomidine).The mean arterial pressure and heart rate before and after anesthesia in two groups were compared.The changes of anesthesia and cognitive function, and the incidence of adverse reactions were compared between the two groups.ResultsCompared with before anesthesia, the mean arterial pressure and heart rate were significantly lower in the two groups (P<0.05).The mean arterial pressure and heart rate in the observation group were significantly lower than those in the control group (P<0.05).There was no significant difference between the two groups in the onset time of motor block sensory block, while the observation group was significantly longer than the control group (P<0.05).The control group patients with Ramsay score below 3 points, a total of 4 cases, accounting for the observation group of patients with Ramsay score of less than 3 points, a total of 24 cases, accounting for 80%, the observation group was significantly better than the control group (P<0.05) sedative effect.Compared with before anesthesia, two groups of patients with postoperative 20min MMSE score were lower, but the observation group MMSE score was significantly higher than that of the control group (P<0.05).There was no significant difference in adverse reactions between the two groups.ConclusionIn the following surgery, the use of local anesthesia combined with dexmedetomidine anesthesia can prolong the time of nerve tissue, and can obtain better sedation and pain, and has little effect on the cognitive function of patients.

Classroom teaching is the focus of teaching of school and main approach to medicine course,and the quality of classroom teaching is directly related to the development of students.Thus improving classroom teaching is very important to increase integral teaching of school.This paper discusses how to increase the thinking ability of students in classroom teaching.

We have reformed the traditional pathophysiological experimental teaching from improving experimental teaching method,optimizing experimental content,updating experimental teaching material,starting design experimental and founding general examine system.

This paper stated the design of DPK colour LCD module and its application for the medical instrument. The hardware interface between MCS-51 and DPK LCD module is presented and the software driver base on KeilC51 language is introduced in this paper. The LCD module is well used in the "Cerebral oximeter for the newborn".