Activin is a growth factor belong to the transforming growth factor-? superfamily.Recently,experimental studies have shown that activin and activin A expressed higher in various brain injury models and activin have beneficial roles to neuronal protection.The high correlation of activin and activin A with clinical and biochemical signs of brain injury lead us to suggest that activin and activin A are new possible indicators to predict and treat brain injury.

Objective: To investigate the risk factors for mortality in neonates with congenital esophageal atresia (CEA) and simple congenital heart disease (CHD) including atrial septal defect (ASD), ventricular septal defect (VSD) and patent ductus arteriosus (PDA). Methods The medical records of neonates with CEA and simple CHD who had surgery in Children’s Hospital of Chongqing Medical University from 1998 to 2013, were analyzed retrospectively. Factors including neonatal demographics, laboratory results and complications after surgery were compared between survivor and non-survivor groups. Results Seventy ifve cases were included in this study and the mortality was 10.67%(8/75). There was no signiifcant difference between non-survivor group (n=8) and survivor group (n=67) in factors such as gestational age, birth weight, age of admission, age at surgery, duration of surgery, full blood examination, serum electrolytes, blood gases, prevalence of septicemia, pneumothorax, and cold lesion syndrome. However, the prevalence of respiratory failure and heart failure in non-survivor group was higher than that in survivor group (75%vs. 9%, P=0.000;50%vs. 1.5%, P=0.000, respectively). Conclusions The poor outcome among neonates with CEA plus simple CHD might be associated with respiratory failure and heart failure.

Objective:To observe the expression of nuclear factor kappa B(NF-kB) during the replacement of primary and permanent teeth in dog. Methods:By immunohistochemistry, expression of NF-kB was examined in the tissues around deciduous tooth root at resorption stage in 2 dogs aged 3-4 months.Results:NF-kB positive signals were observed in the osteoclasts up to the permanent tooth germ and in odontoclasts in the medial wall of the pulp cavity of deciduous teeth.Conlusion:NF-kB may involve in the eruption of permanent teeth during the stage of the replacement of primary and permanent teeth.

Adult ; Aged ; Alveolar Ridge Augmentation ; methods ; Dental Implantation ; methods ; Female ; Humans ; Male ; Maxillary Sinus ; surgery ; Middle Aged

Objective To study the clinical characteristics of obstructive sleep apnea-hypopnea syndrome in the aged. Methods Forty-two over 60 patients with obstruction sleep apnea-hypopnea syndrome (OSAHS) diagnosed by polysomnography (PSG) and 42 matched but less than 60 years OSAHS patients were selected, who were admitted to our hospital from February 2003 to December 2005. The clinical presentations and the results of PSG monitoring were analyzed between the two groups. Results The apnea-hypopnea index (AHI) and microarousal index (MAI) in the aged group were significantly lower than that in the younger group (P0.05). The number of severe OSAHS in the aged group was less than in the younger group (P

Objective To explore the clinical characteristics of rosacea in Xinjiang.Methods From Jan 2013 to Jun 2015,clinical data of hospitalized patients who were diagnosed in the People's Hospital of Xinjiang Autonomous Region as rosacea were analyzed retrospectively.Results (1) The onset age of Uygur and Han were similar,while the incidence of Han was higher than Uygur in 41 ～ 50 age group.(2) The ratio of outdoors was higher in Uygur patients than Han patients.(3) Reactive erythema was the mainly feature in Han patients with obviously self-conscious symptoms including burning,drying,and tingling.The Uyghur patients were present with persistent erythema,papules and pustules;and had facial swelling and mild symptoms.(4) Positive rates of thyroid related antibodies and prolactin were higher in patients with rosacea.Conclusions The clinical features of rosacea are different between Uygur and Han nationalities in Xinjiang.

Objective To provide reference for clinical pharmacist participating in management of nausea and vomiting induced by tumor chemotherapy. Methods The process of pharmaceutical care for a patient with severe vomiting caused by adjuvant chemotherapy after gastric cancer operation was described. Antiemetic application and drug adverse reactions were analyzed. A new treatment plan was given by clinical pharmacist. Results The suggestions were adopted by clinician. The vomiting was controlled and drug adverse reactions were dealt with. Conclusion To reduce the risk and improve the income of antiemetic,clinical pharmacists should pay more attention to clinical practice guideline,drug interaction and adverse reactions, provide the most suitable suggestions for clinicians according to pharmacology and evidence-based medicine.

OBJECTIVE:To summarize the types of esophageal stent implantation and explore the clinical application and complications following esophageal stent implantation.METHODS:A computer-based online search of VIP database (http://www.cqvip.com/) was performed for articles about clinical application of esophageal stent implantation,published between January 1998 and October 2009,with the key words "esophageal stent,indication,complication".The data were collected,and the references were reviewed.Inclusion criteria:Type of esophageal stent;clinical application and complications following esophageal stent implantation.Exclusion criteria:repetitive studies.A total of 22 articles were finally included.RESULTS:Esophageal stent implantation as a novel technique has become an important approach for innocent or malignant esophageal stenosis,as well as orificium fistulae.The metal stent with no cover,partially covered stent and fully-covered stent have effectively cure esophageal diseases.However,patients suffer from the complications,such as chest pain,bleeding and perforation,gastroesophageal reflux,stent dislocation or shedding,and restenosis.Reduction of complications can improve quality of life of the patients.CONCLUSION:There are various types of esophageal stents.Therefore,appropriate selection of type,size,and characteristics of stent according to different disease condition,and accurate operation may minimize incidence of complications.

Animals ; Bone Regeneration ; Bone Resorption ; Cells, Cultured ; Disease Models, Animal ; Humans ; Jaw ; metabolism ; Osteoblasts ; Osteoclasts