Antineoplastic Agents ; adverse effects ; Humans ; Integrative Medicine ; Organoplatinum Compounds ; adverse effects ; Peripheral Nervous System Diseases ; chemically induced

Objective To study the factors such as artificial abortion frequency, pregnancy time and so on on development of adeno-myosis (AM). Methods A retrospective analysis was carried in 462 patients who were from the department of gynaecology and obstetrics in Affiliated Hospital of Nantong University and Beijing Aviation Center Hospital from January 2004 to December 2008. The patients were divided into two groups: AM and no - AM. The two groups were compared for abortion frequency, pregnancy time, age, menarche age and so on. Results There were no significant differences between the two groups in age, menarche age, age of the first artificial abor-tion, bearing frequency, IUD with pregnancy and so on(P > 0.05). The proportion of patients with repeated artificial abortion or history of curettage of uterus in AM group was higher than that in the no - AM group. The patients with pregnaney time more than 8 weeks who re-ceived artificial abortion had higher rate of development of AM. Conclusion Repeated artificial abortion, pregnancy time and history of curettage of uterus were the risk factors of development of adenomyosis.

Objective To explore the value of dynamic contrast-enhanced CT for differentially diagnosing benign and malignant the solitary pulmonary nodules. Methods 117 solitary pulmonary nodules proved by histopathological examination were enrolled in this study. Thin-section CT scanning was performed before and 1,2,3,4 and 5 minutes after contrast enhancement. Results The enhanced value of malignant nodules (39.6?15.8)Hu was significantly higher than that of benign nodules (19.18?17.23)Hu (P

0.05).The proportion of patients with repeated artificial abortion or history of curettage of uterus in AM group was higher than that in the no-AM group.The patients with pregnancy time more than 8 weeks who received artificial abortion had higher rate of development of AM.Conclusion Repeated artificial abortion,pregnancy time and history of curettage of uterus were the risk factors of development of adenomyosis.

Objective To study and design a new algorithm of QT interval measurement based on multi-scale morphological derivative transform(MMDT) according to the demands of mobile monitoring platform.Methods After the MMDT of ECG signals by inducing a triangle and a short line as a pair of structure elements,they were classified into four types by their morphological characteristics and the optimal strategy for each type was described to detect the onset of Q-wave.By introducing the "wing" function,two referenced points of T peak were picked out,which was helpful to locate the peak and offset of T wave,and improve the precision and recognition rate of MMDT method when detecting the bifid T wave(90.9%)and biphasic T wave(86.7%).Results Eighty data records from CSE database were used to evaluate the availability.By contrast with the wavelet transform method,the statistical results showed that the proposed algorithm had generally less error and smaller standard deviation especially for abnormal-phase T wave.Conclusion Compared with those algorithms based on wavelet transform and self-adaptive threshold techniques,our algorithm needs less empirical parameters and calculation.It is also suitable for mobile monitoring and HOLTER system,and has a wide prospect of application.

Objective To investigate the water source pollution by parasitic protozoa in small towns and villages in Shenzhen,China,in order to present the data to establish the national hygienic standard for controlling parasitic protozoa pollution.Methods The samples of water source were collected from 8 village level water plants in Shenzhen.Giardia lamblia and Cryptosporidium were detected,according to the EPA methods,by filtering,rinsing,magnetic isolation and staining.Results Giardia lamblia was found in water sources of 6 water plants and Cryptosporidium was found in one water plant.Conclusion At present,some water sources of village level water plants where the reservoirs were used as the water source in Shenzhen have been polluted by Giardia lamblia and Cryptosporidium,that indicates the potentiality of the water-born-diseases in that areas.

Objective To estimate reliability of magnetic resonance elastography (MRE) in measuring liver stiffness of volunteers and patients with chronic liver disease and to assess inter-rater consistency.Methods MRE was performed on a 3.0 T scanner in all subjects,including 24 volunteers (control group) and 64 patients with liver disease (chronic liver disease group).Liver stiffness was measured blindly by two raters.The pathological fibrosis score was applied as a standard reference for liver fibrosis in 22 patients.The intraclass correlation coefficient (ICC) was used to evaluate inter-rater reliability.The differences of liver stiffness between two groups were evaluated using non-parametric MannWhitney U test.Spearman analysis was used to analyze the correlation between fibrosis stages and liver stiffness.Results The intraclass correlation coefficient of liver stiffness was perfect (ICC =0.99,P ＜ 0.01)between two raters.There was significant difference of mean stiffness between control group and patient group (U =90.5,P ＜0.01) with(2.35 ±0.34) kPa and(4.17 ± 0.47) kPa,respectively.The correlation between fibrosis stage (3,3,5,5 and 6 patients in fibrosis stage S0,S1,S2,S3 and S4) and stiffness (2.13,3.25,3.82,5.45 and 7.35 kPa) was very strong (r =0.96,P ＜0.01).Conclusion MRE is a reliable and promising tool to measure liver stiffness and to assess liver fibrosis.

AIM: To study the clinical efficacy and safety of intravenous immunoglobulin (IVIG) for infant with severe pneumonia.　METHODS: Seventy patients of infant with severe pneumonia were divided into 2 groups. Patinets (n=50) of the trea- tment group (M 30, F 20; age 6 mo± s 5 mo) were treated with IVIG and conventional drugs, IVIG 400 mg*kg-1*d-1 for 3 d. Patinets (n=20) of the control group (M 12, F 8; age 7 mo±7 mo) were treated with conventional drugs.　RESULTS: The duration of fever, tachypnea, high heart rate shortened. The gasp and rales disappeared earlier. The cardiac failure recovered faster than the control group. There was significantly diffference statistically (P<0.05). The level of IgG, IgA raised after treatment. There was significantly difference statistically (P<0.01). The level of CD+3, CD+4, CD+8 after treatment also raised significantly compared with that before treatment (P<0.05). IL-6 and IL-8 after treatment reduced. There was significantly difference statistically (P<0.05).　CONCLUSION: IVIG is safe and effective drug in adjuvant treating severe pneumonia of infant, specially RSV pneumonia.

Objective To develop a new continent cutaneous diversion using a tapered ileum wrapped by rectus abdominis muscular flap. Methods Ten dogs underwent a procedure in which two 6 cm ileal segments were tapered and connected to the U-shaped reservoir which was detubularized by a 30-40 cm ileal segment with end-to-side anastomosis. A continent tube was created by a 6 cm length and 3 cm width rectus abdominis muscular flap with its blood supplied which was penetrated be-tween the mesenteric vessels of one tapered ileum (study tube) and wrapped around its periphery. The other tapered ileum (control tube) was brought out into the abdominal skin directly without any extra-mural support. Urodynamic studies were carried out at 1, 3 and 6 months postoperatively. The data of maximum inner pressure (MIP) and functional pressure length (FPL) of every study and control tubes at every study phase were recorded and statistics analysis were taken. Retrograde radiograms of the ef-ferent tubes were performed prior to sacrifice and histological examinations of study group were carried out after sacrificed. Results The average MIP in experimental group was significantly higher than that in control group at 1, 3 and 6 months post-operatively (P<0.01). However, no significant differences in MIP or FPL were found in study group between empty and full reservoir. In the control group, MIP was found rising significantly (P<0.001) and FPL (P<0.05) decreased sharply com-pared with empty and full reservoir. Retrograde radiograms confirmed that all efferent tubes were pa-tent and positioned straightly beneath the abdominal wall. Histological examination of study group at 6 months postoperatively demonstrated a layer of striated muscle around the serosa of the ileum. Conclusions The continent mechanism of tapered ileum could be enhanced by extramural support from wrapped rectus abdominis muscular flap. This technique could setup a reliable, easy catheterization continent cutaneous efferent tube.

Objective To study the clinical manifestat ions, MR diagnosis and differential diagnosis of sacral meningeal cyst.Methods 25 patients with sacral meningeal cyst proved by operation and pathology, 9 cases of male, 16 cases of female; the age ranged fro m 18 to 56 years old, average age is 40.3. All cases were performed on MR examin ation. Results The shape of cysts in 19 cases were elliptic,long marsupial shape in 3 cases,irregular in 1 case,string shap in 2 cases.The edge of cysts is clear and the wall of cysts is very thin.MR signal in tensity of fl uid in sacral meningeal cysts exhibits similarity to cerebrospinal fluid,which s hows uniform low signal in T 1WI and high signal in T 2WI.There are 8 cases sc an whose MR signal of cysts fluid is much higher than that of cerebrospinal flui d in T 2WI. In 7 cases thin strip nerve root can be found through the cysts in T 1WI and T 2WI. The antrast enhancement was made in 8 cases and there were no any enhancement both in content and wall of cyst.Conclusion MRI is one of the best examing methods for dia gnosiing of sacral meningeal cyst. Correct mastery of MR manifestations can not only help to give right dignosis, but also provide guidance for choices of clini cal treatment.