1.Studying homeostasis from interaction between metabolism and immune system:revelation of ying-wei theory based on complexity science
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(10):-
The interaction between immune response and metabolic regulation can be viewed as a central homeostatic mechanism,dysfunction of which will lead to many diseases.This nonlinear interaction,which has the characteristic of super-complexity,can’t be controlled unless it is studied as a holism and the change of condition is researched.To study this homeostasis,bottom-up method used in system biology is limited.Ying-wei theory of TCM uses another method to describe di erent states of metabolic and immune systems e ectively.The unique approaches and rich experiences applied in TCM are of great value.
3.Cutaneous adverse reactions to molecular targeted antitumor drugs and their management
Fang WANG ; Xuhua TANG ; Hui ZHOU
Chinese Journal of Dermatology 2016;49(7):519-523
There are three kinds of molecular targeted antitumor drugs: inhibitors of membrane?associated therapeutic targets, inhibitors of intracellular signaling pathways, and immunomodulators. Inhibitors of membrane?associated therapeutic targets include epidermal growth factor receptor inhibitors (EGFRIs), KIT and BCR?ABL inhibitors, antiangiogenic agents and multikinase inhibitors. Inhibitors of intracellular signals include inhibitors of the RAS?RAF?MEK?ERK pathway, PI3K?AKT?mTOR pathway and Hedgehog signaling pathway. Inhibitors of cytotoxic T lymphocyte associated?antigen(CTLA) and programmed death 1 (PD?1) belong to immunomodulatory agents. Cutaneous adverse effects of different molecular targeted antitumor drugs share some common features, but also differ from each other. Most of the side effects are dose?dependent and reversible. Management strategies should be adjusted according to the severity of skin eruptions. Dose tapering and even discontinuation of antitumor drugs are necessary for very severe cases, but for mild ones, symptomatic treatment might be enough. This article reviews cutaneous adverse reactions to molecular targeted therapy as well as their prevention and management.
4.Report of a case with Paget disease with bilateral progressive hearing loss as the first symptom.
Li MENG ; Hui-Fang ZHOU ; Jian-Ling WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(7):602-603
Aged
;
Female
;
Hearing Loss, Bilateral
;
diagnosis
;
etiology
;
Humans
;
Osteitis Deformans
;
complications
;
diagnosis
8.Primary maxillary sinus tuberculosis misdiagnosed as fungal sinusitis: a case report.
Jian-ling WANG ; Hong ZHU ; Hui-fang ZHOU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(8):685-686
Diagnostic Errors
;
Female
;
Humans
;
Middle Aged
;
Mycoses
;
diagnosis
;
Paranasal Sinus Diseases
;
diagnosis
;
Sinusitis
;
diagnosis
;
Tuberculosis
;
diagnosis
9.Functional endoscopic sinus surgery for the treatment of fungus ball in paranasal sinuses.
Chang-bao NI ; Hui-fang ZHOU ; Jing ZHANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(3):222-223
Aged
;
Endoscopy
;
Female
;
Humans
;
Male
;
Middle Aged
;
Mycoses
;
pathology
;
surgery
;
Paranasal Sinuses
;
microbiology
;
pathology
;
surgery
;
Retrospective Studies
10.Ultrasound and serological diagnosis of TORCH infection in pregnant women
Fang ZHOU ; Wei WANG ; Shuping ZHAO ; Hui ZHANG
International Journal of Laboratory Medicine 2015;(21):3086-3087
Objective To study the use of ultrasound and serological diagnosis of TORCH infection in pregnant women .Methods Enzyme linked immunosorbent assay of serum IgM antibodies specific for TORCH were performed .Biweekly ultrasonic inspec‐tion were also performed to detect fetal development .Results Among 656 cases of pregnant women ,the TORCH infection rate was 19 .36% ,and the positive rates of IgM specific for toxoplasma ,Rubella virus ,cytomegalovirus ,herpes simplex virus were 3 .50% , 2 .13% ,4 .27% and 4 .72% .Among TORCH antibody positive pregnant women ,ultrasound abnormality included 37 cases of omphalocele ,12 cases of cervical lymph hydrocyst ,4 cases of growth‐stopping ,6 cases of hydrocephalus ,9 cases of fetal death ,16 cases of single umbilical artery hydronephrosis ,12 cases of gastroschisis ,24 cases of intrauterine fetal growth retardation ,and the total abnormal rate was 18 .29% .Among 656 cases of pregnant women ,there are 574 cases of normal deliveries ,including 56 cases of TORCH infection ,accounting for 9 .76% ,and 82 cases with adverse pregnancy outcome ,including 43 cases of TORCH infection , accounting for 52 .44% ,which was higher than that in pregnant women with normal deliveries(P<0 .05) .Conclusion Ultrasound and serological diagnosis of TORCH infection could be reliable and effectively improve the quality of the population .