1.Relationship between Urine Albumin and Vascular Endothelial Growth Factor in Children with Henoch-Schonlein Purpura
nian-fa, CHEN ; yong-qiang, DUAN
Journal of Applied Clinical Pediatrics 2006;0(21):-
0.05],but significant difference existed in children with HSPN compared with HSP and control group[(3.01?1.52) g/d vs (0.05?0.02) g/d or (0.04?0.02) g/d Pa
2.Effect of Endothelin-1 and C-Reactive Protein on Vascular Endothelial Cell Dysfunction in Simple Obese Children
nian-fa, CHEN ; yong-qiang, DUAN
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To explore the effect of endothelin-1(ET-1) and C-reactive protein(CPR) on vascular endothelial cell dysfunction in simple obese children.Methods Thirty-nine simple obese children in the First Hospital of Huangshi City were chosen from Jan.2006 to Jun.2008 as experimental group (obese group) and 21 healthy children as healthy control group with the same age and gender were enrolled in the study.The levels of plasma ET-1 and serum CRP were tested by radioimmunoassay.Data were analyzed with t test and linear correlation analysis.Results Compared with plasma ET-1 level in healthy control group[(43.5?10.2) ng?L-1],the level in obese group[(57.8?19.7) ng?L-1] had significant difference(t=3.704,P
3. Enlightenment of the orphan drug policy and its effect in America
Chinese Pharmaceutical Journal 2014;49(22):2043-2046
OBJECTIVE: To provide a suggestion for legislation of rare disease in China.
4. Comparisons of the 2015 edition of WHO model list of essential medicines for children and the 2012 edition of list of national essential medicines for children
Journal of International Pharmaceutical Research 2016;43(4):602-607
This study focuses on comparing the 2015 edition of WHO model list of essential medicines for children with the 2012 edition of list of national essential medicines for children in respects of drug categories, dosage forms, specifications and medication information. The number of essential medicines available for children in China roughly equals to that of WHO model list of essential medicines for children. Though China’s list provides more specific and children-agreeable specifications, it lags behind the WHO list with respect to the number of dosage forms and information concerning pediatric weight limitation, drug combination and alternatives. It is recommended that research and development on dosage forms for children should be strengthened to solve the problem of pediatric drugs shortage. Also, more clinical trials should be developed as supporting evidence. Based on adapting to the needs of basic health services of children, essential medicines list for children in China should be established.
5.Correlation of Microinflammation,Nutrition and Common Carotid Arterial Intima-Media Thickness
qian, LI ; gen-fa, WANG ; yong-wei, ZHOU ; wei, CHEN
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(07):-
Objective To study the relationship of microinflammation,nutrition and common carotid artery intima-media thickness(CCA-IMT) for the early prevention and interference of ischemic stroke. Methods(CCA-IMT was) measured by carotid arterial ultrasound in 250 elderly subjects.The levels of serum high-sensitivity C-(reactive) protein(hsCRP),ferritin,albumin,pre-albumin and transferrin were assayed at the same time.According to the results of CCA-IMT,all the subjects were divided into five groups:
6.Effects of continuous sciatic nerve block by tetrodotoxin on growth associated protein-43 expression in dorsal root ganglions of normal and sciatic nerve injury rats.
Chen WANG ; Yong-fa ZHANG ; Xiao-yu HUANG
Chinese Medical Sciences Journal 2007;22(4):264-264
Animals
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GAP-43 Protein
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metabolism
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Ganglia, Spinal
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drug effects
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metabolism
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Nerve Block
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Rats
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Rats, Wistar
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Sciatic Nerve
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drug effects
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injuries
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Tetrodotoxin
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pharmacology
7.Association of angiotensin converting enzyme gene polymorphism with genetic susceptibility to systemic lupus erythematosus
Yong WANG ; Jian-Hua XU ; Dong-Qing YE ; Fa-Ming PAN ; Ke-Chun ZHANG ; Li LIAN ; Hong CHEN ;
Chinese Journal of Rheumatology 2003;0(07):-
Objective The aim of this study is to investigate the role of angiotensin-converting enzyme (ACE)gene susceptibility to systemic lupus erythematosus(SLE)by familial studies.Methods PCR-based re- striction fragment length polymorphism(RFLP)was applied to genotype single nucleotide polymorphism(SNP) G261T of the ACE gene.A total of 119 patients with SLE from 119 families were recruited.In addition,316 family members of these patients were also genotyped.A family-based association study was carried out to ex- plore the association between gene polymorphism and SLE.We studied the SNP encoding non-synonymous substitution in the ACE gene with respect to genetic susceptibility to SLE.Results Among 119 SLE patients. the frequency of ACEG261TG,T alleles was 44.8%.55.2% respectively,the frequency of ACEG261T GG,GT and TT genotypes was 13.9%,62.0%,24.1% respectively,Univariate(single-marker)family-based association test(FBAT)demonstrated that variant alleles at the SNP,rs4303,exon 5 of ACE gene were significantly asso- ciated with genetic susceptibility to SLE in Additive Model(Z=2.877,P=0.004),Dominant Model(Z=2.557, P=0.011).Recessive Model(Z=2.202,P=0.028).Transmission-disequilibrium test(TDT)and sib transmission -disequilibrium test(STDT)showed an excess of the allele of T from heterozygous parents to affected offspring or higher frequency of the allele of T in the patients than their normal siblings(X~2=11.66,P=0.001).Conclu- sion Our findings suggest that the ACE gene may he the susceptible gene to SLE in Chinese population,and the individuals carrying ACE-261T allele is significantly associated with susceptibility to SLE.
8.Role of stanniocalcin 1 in brain injury of coal-burning-borne fluorosis rats
Xu-yi, CHEN ; Bing, LIANG ; Feng-wu, TANG ; Yong-chun, ZHANG ; Fa, SUN ; Jiang, GU ; Sai, ZHANG
Chinese Journal of Endemiology 2013;(2):129-132
Objective To observe the change of stanniocalcin 1 (STC1) and calcium content in brain of coal-burning-borne fluorosis rats,and to explore the role of STC1 in brain injury of coal-burning-borne fluorosis.Methods Twenty four male SD rats were randomly divided into control,low,medium,and high fluoride groups according to body mass.Control group was fed conventional rat chow(fluorinated 1.3 mg/kg),and low,medium and high fluoride groups fed with fluorinated feed(20.0,40.0,60.0 mg/kg).All rats were given distilled water and feed ad libitum.One hundred and eighty days after modeling,STC1 protein and gene expression in the brain tissue of rats were detected using immunohistochemistry and RT-PCR and calcium content of brain tissue was detected.Results The cell positive rates of STC1 in low,medium,high fluoride groups [(48.10 + 2.11)%,(54.90 ± 1.73)%,(79.30 ± 3.71)%] were significantly higher than that of the control group[(24.70 + 3.53)%,all P < 0.05],the cell positive rate of high fluoride group was significantly higher than that of the low and medium fluoride groups (all P < 0.05).The STC1 mRNA expression of low,medium and high fluoride groups (0.58 ± 0.09,0.85 ± 0.17,1.75 ± 0.04) were significantly higher than that in the control group(0.37 ± 0.12,all P< 0.05),the STC1 mRNA expressions of high fluoride group was significantly higher than that of the low and medium fluoride groups (all P < 0.05).The brain cortex calcium ion concentrations of low,medium and high fluoride groups[(138.62 + 4.19),(167.43 + 6.57),(189.45 + 3.72)nmol/L] were significantly higher than that in the control group [(101.47 + 9.46)nmol/L,all P < 0.05],the brain cortex calcium ion concentrations of high fluoride group was significantly higher than that of the low and medium fluoride groups(all P < 0.05),and the medium fluoride groups was higher than the low groups (P < 0.05).Conclusion STC 1 may be involved in brain damage of coal-burning-borne fluorosis rats through regulating calcium balance.
9.A comparative study on the photoselective vaporization of the prostate and transurethral electrovaporization resection of prostate for the treatment of benign prostatic hyperplasia.
Yong YANG ; Bao-fa HONG ; Wei-jun FU ; Yong XU ; Yao-fu CHEN ; Cui-e ZHANG
Chinese Journal of Surgery 2007;45(14):951-953
OBJECTIVETo compare the therapeutic effects of the greenlight photoselective vaporization of prostate (PVP) and transurethral electrovaporization resection of prostate (TUVP) for the treatment of symptomatic benign prostatic hyperplasia (BPH).
METHODSOne hundred and sixty-three cases of BPH were treated with PVP and TUVP. All patients were followed up with International Prostatic Symptom Score (IPSS), quality of life (QOL), blood loss, operative time, indwelling catheterization, mean Qmax, residual urinary volume (RUV) and operative complications.
RESULTSIPSS, QOL, Qmax and RUV were significantly improved after either of the procedures (P < 0.05), no significant difference in the improvement of subjective symptoms and objective signs had been noted with the different procedure (P > 0.05). Mean operative time was (37 +/- 15) min for TUVP and (45 +/- 28) min for PVP, the resection time was longer for PVP than TUVP (P > 0.05), but the intraoperative bleeding and catheterization time were less for PVP than TUVP (P < 0.05). Postoperative complications were less for PVP than TUVP (P < 0.05). The incidence of hematuria in TUVP group had been 41.4%, and urinary irritation after PVP group was 55.2% (P < 0.05).
CONCLUSIONSPVP has the same therapeutic effect as TUVP and less adverse side effects than TUVP. It is a new technique for the treatment symptomatic BPH.
Aged ; Aged, 80 and over ; Follow-Up Studies ; Humans ; Laser Therapy ; Male ; Middle Aged ; Prostate ; pathology ; surgery ; Prostatic Hyperplasia ; surgery ; Quality of Life ; Transurethral Resection of Prostate ; methods ; Treatment Outcome
10.Measurement Uncertainty Assessment for Determination of Allura Red in Puffed Food by HPLC
Ying CHEN ; Yun ZHAO ; Hua-Ming WANG ; Qing WANG ; Xi CHEN ; Dong-Qun XU ; Tao LI ; Feng YU ; Xiao-Yong WANG ; Jia-Fa LIU
Journal of Huazhong University of Science and Technology (Medical Sciences) 2018;38(2):324-328
This study aimed to assess the measurement uncertainty of a new method for determination of allura redin food by high performance liquid chromatography (HPLC).The uncertainty of mathematical model of allura red is based on Europe for Analytical Chemistry(EURACHEM) guidelines.The sources and components of uncertainty were calculated,including recovery,working solution,sample mass,final volume,response of standard solution,response of sample solution.The expanded uncertainty was 0.0024 (k=2).Uncertainty of working solution was the most significant factor contributing to the total uncertainty,accounting for 86.2%.The uncertainty of volume accounted for the minimum at 0.025%.The developed method is simple and accurate,which can be used for the determination of allura redin puffed samples.