Toxic epidermal necrolysis is a reactive erythema of nonstaphylococcal origin characterized by a scalded appearance of the skin. The TEN is widely regarded as a variant of severe erythema multiforme because of its acute course, its freguent common cause, its freguent overlap with Stevens-Johnson disease, and its histologic identity. I present a case of TEN with severe mucosal involvement resembled Stevens-Johnson disease.
Erythema ; Erythema Multiforme ; Skin ; Stevens-Johnson Syndrome*

No abstract available.
Erythema Multiforme* ; Erythema* ; Lymphoma*

A clinical and histopsthological study were done on 1,817 biopsied inflammatory skin diseases among 58,386 out-patients in Dermatologic department of Korea University Hospital during the period of 24 years from January, 1962 to December, 1985. The results were summarized as follows : 1. According to pattern analysis(Ackerman AB), 1,605 cases(88.3%) of inflammatory skin diseases were classified into 9 patterns and by author's modified pattern analysis, additional 437 cases could be classified. 2. Of the 1605 cases which were classified by 9 pattern analysis, 1185 cases(78.8%) of inflammatory skin diseases were diagnosed as individual disease entity. The ratio of accordance between the histopathological diagnosis and clinical diagnosis on the biopsied inflammatory skin diseases was 44.5%, 3. The ratio of accordance between the histopathological diagnosis and clinical diagnosis by the patterns were '. Vasculitis(75.5%), Subepidermal vesicular dermatitis (73.3%), Nodular and diffuse dermatitis(68.2%), etc. 4. The diseases showing above the 70% accordance were scleroderma, erythema induratum, vitiligo, arthropod reaction, etc; and the diseases showing under the 30% accnrdance were erythema multiforme, erythema annulare centrifugum, neurodermatitis, etc.
Arthropods ; Biopsy* ; Dermatitis ; Diagnosis ; Erythema ; Erythema Induratum ; Erythema Multiforme ; Humans ; Korea ; Neurodermatitis ; Outpatients ; Skin Diseases* ; Skin* ; Vitiligo

No abstract available.
Erythema Multiforme*

No abstract available.
Erythema Multiforme*

Erythema induratum and erythema nodosum are both inflammatory disorders of the panniculus. However they are often difficult to distinguish because of clinical variations and similarity of histopathologic features. We investigated the clinical and histopathologic features of 30 cases of erythema induratum and 38 cases of erythema nodosum in order to define discrimination of clinical and histopathologic features. The results show that presence of ulceration is clinically important in differentiating erythema induratum from erythema nodosum. Histopathologic findings which suggest erythema induratum include lobular panniculitis or lobuloseptal panniculitis, necrosis and necrotizing vasculitis while erythema nodosum is characterized by predominantly septal panniculitis without necrosis and necrotizing vasculitis.
Discrimination (Psychology) ; Erythema Induratum* ; Erythema Nodosum* ; Erythema* ; Necrosis ; Panniculitis ; Ulcer ; Vasculitis

Sixty-six cases of erythena nodosum(EN) and erythema induraturn(EI) were examined pathologically and clinically. Pathologically 23 cases were erythema nodosum, 43 cases were erytherna induratum. Pathological diagnosis made without any prior knowledge of the clinical and laboratory data. Clinical manifestations were reviewed on basis of pathological diagnosis. The results are as follows; l. EN and EI mainly occurred in female, age of twenties and during spring season. There was no difference in sex, age and seasonal incidence between EN and EI. 2. Both EN and EI affected chiefly the shins. EI was more common than EN in cases of calf involvement. 3. Tenderness and systemic symptoms developed more often in EN, while ulcers occurred only in EI. 4 EI had relatively long duration. There was no difference in the recurrence rate between EN and EI. 5. Pulmonary tuberculosis was found only in El on chest X-rays. 6. Clinical and pathological diagnosis was identical in almost cases of EN but those were variable in case of EI.
Diagnosis ; Erythema Induratum* ; Erythema Nodosum* ; Erythema* ; Female ; Humans ; Incidence ; Recurrence ; Seasons ; Thorax ; Tuberculosis, Pulmonary ; Ulcer

No abstract available.
Erythema Infectiosum*

BACKGROUND: The clinical and histopathological classification of erythema multiforme(EM) and Stevens-Johnson syndrome (SJS) are difficult due to a lack of clear-cut criteria. In recent studies, some authors suggested that erythema multiforme and Stevens-Johnson syndrome were clinically and histopathologically different disorders. OBJECTIVE: The purpose of this study was to review the clinicopathological characteristics of the EM and SJS and to suggest specific findings for differentiating between the two diseases. METHODS: Fifty four patients with EM and SJS diagnosed in the Department of Dermatology of Dong-San Hcepita1 from January 1987 through to December 1996 were studied retrospectively. RESULTS: The results were summarized as follows. l. In view of causal factors, 54 cases were classified as drug-induced (n=22, 41%), herpes-induced (n=16, 30%), tuberculosis (n= 2, 3%), pneumonia (n=l, 2%), unknown (n=13, 24%). 2. Fifty four cases were clinically classified as SJS (n= 29, 54%), EM minor (n=-15, 2S%) and EM major (n = 10, 18%). 3. Erythema multiforme was found to be more related to herpes (13 of 25 cases) than to drugs (3 of 25 cases), while SJS was more related to drugs (19 of 29 cases) than to herpes (3 of 29 cases). 4. Varying degrees of necroti changes of keratinocytes were found in all the cases. The severity of degree or extent of necrosis was higher in patients with SJS than EM. 5. In demial changes, EM showed differences from SJS by having a denser and deeper lymphocytic infiltrate, and increased amount of extravasated erythrocytes. CONCLUSION: Taken together, although our findings could not provide a defmite clue to determine whether EM and SJS are different distinet entities or not, this study may be useful to differentiate and to understand the pathogenesis of EM and SJS. A prospective large scaled study should be conducted to definitively characterize these entities.
Classification ; Dermatology ; Erythema Multiforme* ; Erythema* ; Erythrocytes ; Humans ; Keratinocytes ; Necrosis ; Pneumonia ; Retrospective Studies ; Stevens-Johnson Syndrome ; Tuberculosis

Terbinafine is now widely used for the treatment of dermatophytic infections of the skin and nails. Cutaneous side effects of terbinafine are rare and mild. They includes erythema, pruritus, urticaria, desqumation, and macular exanthem. In addition, fixed drug eruption, erythema multiforme, Stevens-Johnson syndrome, and erythema annulare centrifugum-like psoriatic drug eruption were recently described in the literatures. Herein, we reported a case of acute generalized exanthematous pustulosis induced by terbinafine.
Acute Generalized Exanthematous Pustulosis* ; Drug Eruptions ; Erythema ; Erythema Multiforme ; Exanthema ; Pruritus ; Skin ; Stevens-Johnson Syndrome ; Urticaria