No abstract available.
Lithium Chloride* ; Lithium*

No abstract available.
Bismuth* ; Gentamicins* ; Mercuric Chloride*

No abstract available.
Child* ; Humans ; Methacholine Chloride*

No abstract available.
Child* ; Humans ; Methacholine Chloride*

BACKGROUND: Airway hyperreponsiveness is a cardinal feature of asthma. It consists of both an increased sensitivity of the airways, as indicated by a smaller concentration of a constrictor agonist needed to initiate the brochoconstrictor response and an increased reactivity, increments in response induced subsequent doses of constrictor, as manifested by slopes of the dose-response curve. The purpose of this study is to observe the relationship between bronchial sensitivity and reactivity in asthmatic subjects. METHOD: Inhalation dose-response curves using methacholine were plotted in 56 asthmatic subjects. They were divided into three groups(mild, moderate and severe) according to clinical severity of bronchial asthma. PC20 were determined from the dose-response curve as the provocative concentration of the agonist causing a 20% fall in FEV1. PC40 were presumed or determined from the dose response curve, using the PC20 and the one more dose after PC20. Reactivity was calculated from the dose-response curve regression line, connecting PC20 with PC40. RESULTS: PC20 were 1.83mg/ml in mild group, 0.96mg/ml in moderate, and 0.34mg/ml in severe. PC4O were 7.17mg/ml in mild group, 2.34mg/ml in moderate, and 0.75mg/mI in severe. Reactivity were 24.7+/-17.06 in mild group, 46.1+/-22.10 in moderate, and 59.0+/-5.82 in severe. There was significant negative correlation between PC2O and reactivity (r=-0.70, P<0.01). CONCLUSION: Accordingly, there was significant negative correlation between bronchial sensitivity and brochial reactivity in asthmatic subjects. However, in some cases, there were wide variations in terms of the reactivity among the subjects who have similar sensitivity. So both should be assessed when the bronchial response tor bronchoconstrictor agonists is measured.
Asthma* ; Inhalation ; Methacholine Chloride

Due to a failure in communication, the original rather than revised manuscript.
Ganoderma* ; Sodium Chloride* ; Sodium*

The purpose of this study was to assess and evaluate salty taste preferences. Samples for the salty taste test were made by adding sodium chloride to soybean sprout soup at five different concentrations: 0.08% (unsalty); 0.16% (slightly unsalty); 0.31% (neither unsalty nor salty); 0.63% (slightly salty); and 1.25% (salty). Over 4,210 subjects were randomly selected and tested over a three-year period from 2005 to 2007 in Daegu. The results of the taste test were as follows: Fortyfive percent of the subjects preferred soup with a salty taste and slightly salty taste. Most subjects preferred soup with a 0.31% concentration of sodium chloride. There were positive relationships between intensity and preference in 0.08%, 0.16%, and 0.31% concentrations, but there were negative relationships between intensity and preference in 0.63% and 1.25% concentrations (p < 0.01). Upon examining a relationship between the taste assessment results and salty eating attitude scores, it was found that the subjects who preferred slightly salty and salty taste showed higher total scores in terms of habitual preference for/enjoyment of eating salty foods than the other groups. Comparing the taste test results with the subjects' stated preference, it was found that 70.3% of the subjects who were classified as preferring salty taste recognized this preference and 53.3% of the subjects who were classified into the population than tends to eat slightly salty food responded that they also tend to prefer a salty taste. Based on these results, this salty taste assessment study can be used as a practical and useful nutrition education tool for assessing and possibly reducing salt intake.
Eating ; Sodium Chloride ; Soybeans

No abstract available.
Humans ; Methacholine Chloride* ; Rhinitis*

OBJECTIVES: The study was performed to investigate the changes of urinary thiodiglycolic acid (TDGA) concentration in workers exposed to vinyl chloride monomer (VCM) according to the time of sampling urine. METHODS: The personal exposure to airborne VCM was assessed and urinary TDGA concentration was sampled in 31 workers employed in a VCM and polyvinyl chloride (PVC) manufacturing factory. Urinary TDGA was sampled three times: before the start of the shift after 3 days off (TDGA1), after the end of the first-day shift (TDGA2) and before starting the following day shift after completing the oneday shift (TDGA3). Urinary TDGA in 30 workers who had not been exposed to airborne VCM was sampled after the end of the shift. A gas chromatography/pulsed flame photometric detector (GC/PFPD) was utilized to analyze TDGA concentration in urine after the urine was methylated with trimethylsilyldiazomethane(2.0M in diethyl ether). RESULTS: The creatinine level was 0.179+/-0.271 mg/g in the control workers and 0.218+/-0.443 mg/g in the workers before the start of the shift after 3 days off (TDGA1), showing no significant difference (p=0.7035). Urine samples were compared according to sampling time in order to investigate the change of urinary TDGA concentration in the case of continuous exposure to airborne VCM. In VCM-exposed workers, urinary creatinine concentration was 0.434+/-0.623 mg/g in TDGA2 and 0.767+/-1.056 mg/g in TDGA3, which indicated a gradual but significant increase (p=0.024). In terms of the statistical correlation between airborne VCM and urinary TDGA to evaluate exposure dose per day, of the three urinary TDGA concentrations, TDGA3 showed the highest degree of regression (R(2)=0.4215) with 8h-TWA airborne VCM concentration. CONCLUSION: Based on this result, the excretion half-life of urinary TDGA was assumed to be less than 3 days, because the concentration of urinary TDGA at 3 days after exposure to airborne VCM was decreased to the level of urinary TDGA concentration in the control workers. The concentration of urinary TDGA increased in the case of continuous shift, due to the accumulation of residual metabolites of TDGA. It was considered that TDGA3 can be applied as a useful biological index to evaluate the exposure dose of airborne VCM during one day because TDGA3 showed the highest correlation with the exposure dose of airborne VCM in the previous shift day.
Creatinine ; Half-Life ; Humans ; Polyvinyl Chloride ; Vinyl Chloride*

PURPOSE:Bronchial hyperresponsiveness (BHR) to methacholine and exaggerated peak expiratory flow (PEF) variability are hallmarks of asthma. The aims of our study were to evaluate the relationship between PEF variability and BHR to methacholine and which PEF index correlates best with BHR to methacholine. METHODS:Methacholine challenge test was performed in 73 children having mild to moderate asthma. Those subjects recorded PEF morning and evening before and after bronchodilator for 2 weeks. The response to methacholine challenge was measured by PC20 (provocative concentration causing a 20% fall in FEV1), and seven different PEF variability indices(including prebrochodilator amplitude%mean, postbronchodilator amplitude%mean, standard deviation%mean) were calculated. RESULTS:Geometric mean of methacholine PC20 was 1.7 mg/mL. All PEF variability indices were associated with BHR to methacholine. Among PEF variability indices, two indices showed the best correlation with BHR to methacholine: standard deviation%mean (r=-0.45, P<0.001) and postbronchodilator amplitude%mean (r=-0.42, P<0.001). CONCLUSION:Standard deviation%mean provided the strongest correlation with BHR to methacholine. Meanwhile, postbronchodilator amplitude%mean which is counted easily and is more intuitively visualized manifested similar correlation as standard deviation%mean. Methacholine challenge test and PEF variability were correlated significantly but weakly; therefore we supposed that they do not reflect the same pathophysiological process in the airways.
Asthma* ; Child* ; Humans ; Methacholine Chloride*