No abstract available.
Ophthalmology*

Here, we report 3 cases of mixed tumor of the lacrimal gland. The age of the patients were 43, 26 and 35 respectively. The two of these were male and one female. The most outstanding complaint was exopthalmos. A mass was palpated on the orbit and eye ball deviation in downward position was present in all cases. Pathologic findings were mixed tumor of the lacrimal gland with no evidence of malignancy. These tumors were well encapsulated and any evidence of involving bone and soft tissue was not found. Modified Kroenlein-Berke operation was performed and tumor mass was removed entirely with finger dissection in all cases. The vision was not improved but the cosmetic result was satisfactorr.
Female ; Fingers ; Humans ; Lacrimal Apparatus* ; Male ; Orbit

The tension lowering effects of Diamox and other carbonic anhydrase inhibitors are well known and they are widely used against a various forms of glaucomas. This paper deals with the clinical experiences in normal and glaucomatous human eyes with Diamox-Sequels, kindly supplied by Lederle Laboratories and Yuhan Corp. MATERIALS AND METHODS: Normal healthy persons, 15 females and 20 males, were studied on their 45 eyes. Glaucomatous disease had been ruled out by careful examinations of intraocular pressure, visual fields and fundus. They had been also checked for the diurnal variations of intraocular pressure during the daytime. One capsule (500mg) of Diamox Sequels was given to each individual and the changes in the intraocular pressure were studied at various time intervals up to 53 hours after the administration. Tonometry was carried out by the Goldmann's applanation tonometer. The effects of Diamox Sequels on the glaucomatous eyes were studied in the same way. The glaucomatous eyes included 10 eyes of 7 chronic simple glaucoma patients, 5 eyes of 3 chronic narrow-angle glaucoma patients and 5 eyes of 5 secondary glaucoma subjects. They received one capsule of Diamox Sequels and the intraocular pressure was measured one or two times daily. The results of long-term treatment were also studied by daily administration of one capsule of Diamox Sequels, follow-up periods being from 3 to 19 days. No medication, oral or local, of antiglaucomatous drugs were allowed for at least 3 days prior to this study. The differences due to age, sex and type of glaucoma were not considered here. At the same time, the effects of a single 500mg of ordinary Diamox tablet were studied in normal ~md glaucomatous eyes. RESULTS: (1) Normal eyes. The intraocular pressure began to fall 1 hour after the administration. The tension gradually fell and the maximal reduction of tension occurred after 9.8 hours and the extent of maximal fall was 4.5mm Hg on the average, 29.4 % of the original intraocular pressure. The tension gradually rose and returned to the original level between 23~50 hours (average 43 hours). Side effects were noted in 4 cases, e.g., 11.4 %. (2) Glaucomatous eyes. The effects were noted within the first 1~2 hours and became maximal after 13 hours, the extent of the maximal fall 40.1 % of the original pressure, e.g., 16.2 mmHg. The original tension was restored after 30 hours. By long-term administration of Diamox Sequels, 8 eyes(40 %) showed excellent results, their intraocular pressure maintained below 21 mmHg. Sede-effects were noted in 3 cases(20.0 %). COMMENTS: The effects of Diamox Sequels and Diamox tablet on normal and glaucomatous subjects were summarized in table 1. As shown, Diamox Sequels has the longer duration of hypotensive actions and the time of maximal fall of intraocular pressure delayed considerably, as compared with Diamox tablet. In almost all cases, its action continued for more than 24 hours. In glaucomatous eyes, the time of maximal reduction of ocular tension was slightly later and the maintenance of low tension was slightly shorter than those in normal eyes. The extent of the maximal fall, however, was almost the same after administration of Diamox Sequels and Diamox. Side effects were encountered in 11~20% of cases by Diamox Sequels, and in 40-60% of cases by Diamox. This is one of the most striking advantages of Diamox Sequels over Diamox. Thus it is concluded that Diamox Sequels has the longer hypotensive actions and fewer side effects.
Acetazolamide* ; Carbonic Anhydrase Inhibitors ; Female ; Follow-Up Studies ; Glaucoma ; Glaucoma, Angle-Closure ; Glaucoma, Open-Angle ; Humans ; Intraocular Pressure ; Male ; Manometry ; Strikes, Employee ; Visual Fields

There were many instances in which glaucoma, esp. primary, combined with hearing disturbance. The etiology of these cases has not been known until now. We had 15 primary glaucoma patients for whom pure tone audiometry wa~ performed, and could find the hearing defect in high tone in 5 cases (1/3 among those patients). The audiometric curve was similar to that in the presbycusis, but severer in degree than that occured within the normal physiological aging process. The average age was 62.4 year in the group with the hearing defect, and 45.6 year in the group without the hearing defect. There were no relationship between the hearing defect and intraocular tension, visual field change, glaucomatous cupping, and duration of glaucoma. These results may support the opinion of the authors that the hearing disturbance in glaucomatous patients is related to the arterioscIerotic changes which aggrevate the presbycusis, and not related to glaucoma itself. On the otherhand, however, it is stilI impossible for us to rule out that the pleiotropic and multifactorial genetic factors may play as a common important role in the hearing disturbances and glaucoma. And further studies would be necessary for these problems.
Aging ; Audiometry ; Glaucoma* ; Hearing* ; Humans ; Presbycusis ; Visual Fields

The extensibility of the albino rabbit sclera was measured after cryoapplication and diathermy on the equator of sclera and these extensibilities were compared with normal control. For cryoapplication, 95% alcohol and solid carbon dioxide mixture was used and this cryoprobe was applied on the equator of rabbit sclera of right eye for 3 seconds. Castroviejo apparatus was used for diathermy and nonperforating surface diathermy was performed on the equator of rabbit sclera of left eye for one second with current of 30mA. Immediately after cryoapplication and diathermy, the extension rates of sclera were 2.556% and 6.039%, respectively. The extension rates of one week after cryoapplication and diathermy were 3.234 % and 4.127%, respectively. The extension rate of two weeks after diathermy was 3.489%. Normal control was 3.055%.
Carbon Dioxide ; Diathermy* ; Sclera*

In order to evaluate the incidence of lateral incomitance after monocular recession and resection and compare the amount of correction achieved by monocular recession and resection according to the gaze direction and distance in exodeviations, we measured the angle of deviation in primary, right, left, up, down and near gaze before and after monocular recession and resection. Lateral incomitance was developed in11.4%(9/79) after monocular recession and resection. The amount of correction of the deviation toward the side of operated eye was larger than that of the deviation in primary position(p=0.002), but the amount of correction of the deviation toward the side of non-operated eye, up, down and near gaze was all smaller than that of the deviation in primary position(all, p<0.01).
Exotropia* ; Incidence

Overaction of the inferior oblique(IO) muscle is manifested by elevation of the adducted eye and from the clinical point of view there are two types of overaction. The primary type is of unknown cause, whereas the secondary type is usually related to the palsy of the ipsilateral superior oblique or contralateral superior rectus. An ultrastructural study on the overacting IO muscles was performed compared to normal IO muscles by electron microscopy. Of 16 biopsies of overacting IO muscles, four had primary overacting inferior obliques and twelve had secondary overacting inferior obliques due to paralysis of superior oblique muscle. Additional four IO muscle, obtained from patients with intraocular diseases served as control specimens. The most striking abnormalities were aggregations of mitochondria and degenerating mitochondrial profiles and increased vacuolization in primary and secondary overacting muscles. Many muscle fibers were in different stages of atrophy, and hypertrophy and regeneration of muscle fibers were sometimes visible. The results suggest that the primary overacting IO muscle might be the result of a paresis of the superior oblique muscle.
Biopsy ; Humans ; Mitochondria/ultrastructure ; Ocular Motility Disorders/*pathology ; Oculomotor Muscles/*ultrastructure ; Ophthalmoplegia/pathology ; Vacuoles/ultrastructure

Local anesthetics that are commonly used in ophthalmic surgery(0.5% bupivacaine hydrochloride, 2.0% lidocaine hydrohloride, 0.38% bupivacaine-1.0% lidocaine-1:100,000 epinephrine mixture) were injected into the retrobulbar space of rabbit eyes. Physiologic saline was injected into that spaces in control group in the same manner. All three anesthetics produced degeneration of the extraocular muscles to a varying extent. Muscle degeneration was followed by rgeneration of the damaged muscle fibers. In addition to muscle damage, severe damage to harderian gland was also seen in lidocaine-injected group. The optic nerve was not affected. With these findings in rabbits, it is hypothesized that the temporary diplopia and ptosis sometimes seen in patients after ophthalmic surgery might be due to anestheticsinduced damage to the extraocular muscles.
Anesthesia* ; Anesthetics ; Anesthetics, Local ; Animals ; Bupivacaine ; Diplopia ; Epinephrine ; Harderian Gland ; Humans ; Lidocaine ; Muscles* ; Optic Nerve ; Rabbits

Under the general anesthesia the effect of topical anesthesia on the incidence of oculocardiac reflex was investigated by preoperative instillation of 0.5% tetracaine into the 48 eyes during horizontal strabismus muscle surgery. In all cases, recession was done first. The results were as followings: 1. The incidences of oculocardiac reflex in treated and control group were 33% and 71% respectively and the difference was statistically significant(p<0.025). 2. The reduction in the incidence of oculocardiac reflex was noted both in recession and resection. But there was no statistically significant difference between treated group and control group in resection. 3. The incidence of oculocardiac reflex was not related with age, sex, type of strabismus, kind of muscles and type of surgery.
Anesthesia* ; Anesthesia, General ; Incidence ; Muscles ; Reflex, Oculocardiac* ; Strabismus ; Tetracaine

Horizontal incomitancy is a difference of deviation angle between right and left gaze and monocular recession-resection operation may cause horizontal incomitancy. We reviewed 85 patients of intermittent exotropia without oblique dysfunction and vertical deviation who underwent monocular recession-resection operation. The preoperative horizontal in comitancy was 1.0 delta in average with a range of 0 delta to 5 delta. The postoperative horizontal incomitancy after 7 months (mean) was 4.8 delta in average with a range of 0 delta to 17 delta. The postoperative remained deviation and horizontal incomitancy were significanty smaller in the group of patients who had fusion with worth 4-dot test (p Exotropia ; Humans