Introduction: Low 25-hydroxyvitamin D [25(OH)D] levels have not been consistently associated with bone mineral density (BMD). It has been suggested that calculation of the free/bioavailable 25(OH)D may correlate better with BMD. We examined this hypothesis in a cohort of Malaysian women. Materials and Methods: A cross-sectional study of 77 patients with rheumatoid arthritis (RA) and 29 controls was performed. Serum 25(OH)D was measured using the Roche Cobas E170 immunoassay. Serum vitamin D binding protein (VDBP) was measured using a monoclonal enzymelinked immunosorbent assay (ELISA). Free/bioavailable 25(OH)D were calculated using both the modified Vermuelen and Bikle formulae. Results: Since there were no significant differences between RA patients and controls for VDBP and 25(OH)D, the dataset was analysed as a whole. Calculated free 25(OH)D by Vermeulen was strongly correlated with Bikle (r = 1.00, p < 0.001). A significant positive correlation was noted between measured total 25(OH)D with free/bioavailable 25(OH) D (r = 0.607, r = 0.637, respectively, p < 0.001). Median free/bioavailable 25(OH)D values were significantly higher in Chinese compared with Malays and Indians, consistent with their median total 25(OH)D. Similar to total 25(OH)D, the free/bioavailable 25(OH)D did not correlate with BMD. Conclusion: In this first study of a multiethnic female Malaysian population, free/bioavailable 25(OH)D were found to reflect total 25(OH)D, and was not superior to total 25(OH)D in its correlation with BMD. Should they need to be calculated, the Bikle formula is easier to use but only calculates free 25(OH)D. The Vermuelen formula calculates both free/bioavailable 25(OH)D but is more complex to use.
bone mineral density

Introduction: Ankylosing Spondylitis is a chronic rheumatic arthritis with specifically related to lumbar spine and femoral neck. The disease is more common in young men. Inflame and inactive condition of patients with Ankylosing Spondylitis leads to a low bone mineral density. Determining osteomalacia has clinical significance because of the relation to bone density.\r\n', u'Objectives: To study the prevalence of osteoporosis and osteopenia in Ankylosing Spondylitis and to investigate correlation between bone mineral density and age at the beginning of the disease, BASDAI, BMI\r\n', u'Subjects and methods:119 male patients with ankylosing spondylitis, mean age of 29.0 \xb1 10.8 as defined by New York criteria modified in 1984. Bone mineral density was measured at the lumbar spine and hip with Unigamma X ray - Plus. Results: 26.1 % of patients had lumbar spine osteopenia and osteoporosis, while 41.2% had femoral neck osteopenia and osteoporosis. The beginning of the disease was 22.1 \xb1 7.8 and had correlation with bone density in lumbar spine. Low BMI group had decreased bone density in lumbar spine and femoral neck (BMI < 18.5), (p=0.0001 and p=0,005, respectively). Patients with active disease had lower bone density than those with stable disease.\r\n', u'Conclusion: Ankylosing spondylitis patients have decreased BMD values at both the spine and femur. Bone mineral density at lumbar spine and femoral neck had correlation with the BMI, Bone mineral density at femoral neck had correlation with BASDAI. \r\n', u'
Ankylosing spondylitis ; Bone mineral density ; Osteoporosis ; DXA.

No abstract available.
Bone Density*

No abstract available.
Bone Density*

No abstract available.
Bone Density*

Introduction: Citrate is commonly used as an anti¬coagulant during plateletpheresis procedure. The calcium chelating property of citrate may cause hypocalcaemia when the anticoagulated blood are returned to the donor’s circulation after selective removal of platelet. This study aims at investigating how regular plateletpheresis affects calcium level and bone density in the donors. Methods: A cross-sectional study was conducted among healthy donors at National Blood Centre, Kuala Lumpur, from 15th January till 31st March 2016. Donors were divided into two groups based on the frequency of plateletpheresis donation: low frequency group - donors who had donated less than 20 times, high frequency group - donors who had donated more than 50 times. Dual emission X-ray absorptiometry (DEXA) scan was performed to assess bone density. Pre-donation blood sampling was taken for albumin level. Calcium and magnesium levels were measured before and after donation. Results: Fifty donors participated in this study where the median age of participants was 35.0 years for low frequency and 45.2 years for high frequency group. There was no significant difference in the corrected calcium for both groups before and after plateletpheresis. However, the magnesium levels were significantly reduced in both arms (P<0.05). The albumin level and DEXA scan showed no significant differences between the groups. Conclusion: This study did not show any significant difference in calcium levels, albumin and bone density; but donors’ magnesium levels were reduced in low and high frequency donors after plateletpheresis.
Bone density

Background: Post-menopausal women experiences changes in estrogen levels affecting body metabolism, which may lead to weight gain and obesity. Moreover, one of the most prevalent diseases among this group is osteoporosis. However, the relationship between fat mass and its protective property remains unclear. This study assesses the correlation of fat mass with bone mineral density (BM) and 10-year FRAX based fracture probability among Filipino women. Methods: A cross-sectional review of records of post-menopausal Filipino women who underwent whole body bone mineral densitometry scans via dual-energy X-ray absorptiometry (DXA) between January 1, 2015, and December 31, 2018 in the Radioisotope Laboratory of the Philippine General Hospital was done. Pearson correlation and simple linear regression analyses were done to determine the correlation between the two outcomes – BMD and 10-year FRAX based fracture probability. Results: A total of 258 postmenopausal women were included in the analysis. There was a weak positive correlation of fat mass with BMD of L1-L4 vertebrae (R-score of 0.318), BMD of femoral neck (R-score of 0.3937) and hips (R - score of 0.3031). The 10-year FRAX based fracture probability for both hip and osteoporotic had very weak and weak negative correlation, respectively (R-score of - 0.06752 and - 0.29017). Conclusion Despite having varying available, data on the protective effects of fat mass on fracture protection, this study showed that fat mass has a poor correlation with BMD and reduction in FRAX probability.
Postmenopause ; Bone Density ; Fractures, Bone

No abstract available.
Bone Density ; Humans ; Male

No abstract available.
Bone Density ; Humans ; Male

Although exercise is effective to prevent or to treat osteoporosis, it is not certain how much exercise is needed. Therefore the amount of exercise should be dependent on the individual's ability to exercise and the bone mineral density, and the type and method of exercise should be individualized. Patients with osteoporosis should be careful not to fall or slip down and should avoid strenuous spinal motion. The goal of treatment of osteoporosis is not only to increase bone mineral density but also to improve general body health.
Bone Density ; Humans ; Osteoporosis*