0.05).Conclusion IPAT sequence can gain super images in less time with more coils.IPAT sequence needs the distance between coil and checkpoint larger than 5 mm.MRI scan for vertebra just fit it.We think cutting scan time is a direct and effective method to decrease constructed defect.

Objective To explore the influence of positive psychological quality on the quality of life of rural left behind elderly. Meth-ods 356 rural left behind elderly in Bengbu and Huaibei cities of Anhui province were investigated with WHO Quality of Life-BREF (WHO-QOL-BREF), Chinese version of the Meaning in Life Questionnaire (C-MLQ), Purpose-in-Life Test (PIL) and Index of Well-Being (IWB). Results The scores of WHOQOL-BREF in physical, psychological, social relations and environment are significantly lower in the rural left behind elderly than in the norm in China (t>3.105, P<0.001). The scores of WHOQOL-BREF of the left behind elderly in rural areas signifi-cantly correlated with the sense of life meaning, life objective and subjective well being (P<0.05). The quality of life of left behind elderly in rural areas was analyzed by regression analysis, age, health status, education and other demographic variables and life goals, life sense, sense of autonomy, etc. entered the regression equation (P<0.05). The structure model analysis showed that the life meaning and purpose of life were the important factors that affected the quality of life of rural left behind old people, in which the subjective well-being played a meditational role. Conclusion The positive psychological quality of life meaning, life purpose and other positive psychological qualities sig-nificantly impact the quality of life of rural left behind elderly, and should carry out targeted mental health guidance.

Objective To explore the effect of psychological intervention on the rehabilitation of depressive patients.Methods 183 depressive patients were randomly divided into study group (n=93) and control group (n=90). The study group was given systemic psychological intervention additional to routine medicine for 12 weeks and the control group was given only medication. The efficacy was measured by Brief Psychiatric Rating Scale (BPRS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS).Results There is no significant difference in SDS, SAS and BPRS ratings between two groups before the intervention (P>0.05). The scores of anxiety-depression, lacking-activity, thinking-disturbance, SAS and SDS were significantly lower in the study group than in the control group 12 weeks after the intervention(P<0.05). Conclusion Psychological intervention can positively improve the rehabilitation of depressive patients.

Objective: To investigate the effects of total paeony glucoside on brain Notch signaling pathway in focal cerebral infarction rats. Methods: Stroke rats were prepared and divided into 5 groups: model group, low dosetotal peony glucoside group, medium dosetotal peony glucoside group, and high dosetotal paeony glucoside group, with 20 rats in each group. All groups received the medication for 20 days. The body weight, brain water content, cerebral infarction size, brain tissue NICD, Hes1 and Hes5 proteins and Hes1 and Hes5 mRNA expressions were measured in each group. Results: There was no significant difference in body weight before administration within these groups (P>0.05). After treatment, compared with those in the control group, the body weight significantly decreased (P<0.05); NICD, Hes1 and Hes5 significantly increased; Hes1 and Hes5mRNA significantly increased in the model group (P<0.05). Compared with those in the model group, the body weight significantly increased (P<0.05); the NICD, Hes1 and Hes5 significantly decreased; Hes1 and Hes5mRNA significantly decreased (P<0.05) in a dose-dependent manner. Conclusion: Total peony glucoside can treat focal cerebral infarction by inhibiting Notch signaling pathway in rat brain tissue.

Objective:To investigate the influential factors of mental health in rural high-school students by structural equation modeling.Methods:447 rural high-school students were tested by Mental Health test,Adolescent Self-rating Life Events Check list,Social Support Scale and Trait Coping Style questionnaire,then theoretical model were established and confirmed for the relationships of life events,social support,coping styles and mental health of rural high-school students.Results:The structural equation modeling fitted the data very well(?2/df=3.56,GFI=0.940,AGFI=0.902,NFI= 0.913,CFI=0.901,RMSEA=0.048),the theoretical model suppose was supported by the use of structural equation modeling.Conclusion:Social supports and coping styles have direct influence on mental health of rural high-school students.Life events have indirect influence on mental health through social supports and coping styles.

Objective To inspect the therapeutic effect and prognosis of treating Unstabled Angina Pectoris (UAP) with drugs and interventional methods.Methods 40 patients were treated randomly with PTCA and stenting or traditional drugs: Beta blockers, Calcium resistants, Ester nitrates, Asprin, Heparin and so on.Compared degrees of angin pectoris, cases of AMI, mortality arising from heart disease or no heart disease before and 8 months after the treatment. Results Happening of AMI and mortality in interventional group were less than those of drugs group. Distinctly improving rate of clinical effect of the former was much more than that of the later.Conclusion In short term interventional treatment (PTCA and stenting) were piror to drugs in therapeutic effects and improving prognosis.

Objective Evaluation of the benefit and safety of combined thrombolysis and precutaneous coronary intervention in acute myocardial infarction by retrospective analysis. Methods Precutaneous coronary intervention were performed in 45 patients with acute myocardial infarction immediately after thrombolysis. The clinical and angiographic data were compared with that of 31 patients with thrombolysis alone and 74 patients with primary precutaneous coronary intervention in the same period. Results Angiographic data showed that patients with PCI plus thrombolysis had more frequency of TIMI 3 flow than patients with thrombolysis alone (88.9% vs. 74.2%, P=0.087). Patients with PCI plus thrombolysis and with primary PCI had similar frequency of TIMI 3 flow (88.9% vs. 91.9% P=0.404). Clinical data showed that patients with PCI plus thrombolysis had less major adverse cardiovascular events in hospital than patients with thrombolysis alone (4.4% vs. 12.9%, P=0.181). Patients with PCI plus thrombolysis and with primary PCI had similar major adverse cardiovascular events (4.4% vs. 1.4%, P=0.319). Patients with three strategies of treatment had similar mortality (4.4% vs. 6.5% vs. 4.1%). Patients with three strategies of treatment had similar major bleeding events (4.4% vs. 3.2% vs. 1.4%) in hospital. Conclusion Combined thrombolysis and precutaneous coronary intervention maybe surpass thrombolysis alone, at least similar to primary PCI. This strategy of treatment is safe.

Objective To investigate the genetic damage of human bronchial epithelial cells (HBE) caused by cigarette smoke combined with nano-TiO2.Methods 16-HBE cells were exposed to cigarette smoke extract (CSE) and nano-TiO2(mg/L) at the doses of 0 mg/L CSE+0 mg/L nano-TiO2,50 mg/L CSE+0 mg/L nano-TiO2,75 mg/L CSE+0 mg/L nano-TiO2,100 mg/L CSE+0 mg/L nano-TiO2,0 mg/L CSE+10 mg/L nano-TiO2,50 mg/L CSE+10 mg/L nano-TiO2,75 mg/L CSE+10 mg/L nano-TiO2,100 mg/L CSE+10 mg/L nano-TiO2. After 24 h exposure,HBE viability was evaluated by the methyl thiazolyl tetrazolium (MTT) assay,single cell gel electrophoresis (SCGE,comet assay) was employed to assess DNA damage,chromosomal aberration was measured by micronucleus test. Results Except the group exposed to 10 mg/L nano-TiO2,HBE viability of the other treatment groups were lower than that of the control group and Comet % of the other treatment groups were higher than that of the control group (P

Objective To study the effect of cyclophosphamide pulse therapy combined with leflunomide (LEF) on refractory lupus nephropathy (RLN).Methods Thirty-six patients diagnosed as RLN were selected.Several observation parameters were compared before and after cyclophosphamide pulse therapy combined with LEF.The observation parameters included serum albumin,serum complement C3 and C4,systemic lupus erythematosus (SLE) activity index and urinary protein change.The side effects of cyclophosphamide pulse therapy combined with LEF were observed.Results The serum albumin was (20.17 ± 4.09) g/L,complement C3 was (0.40 ± 0.19) g/L,complement C4 was (0.08 ± 0.03) g/L,SLE activity index was 16.06 ± 4.17,and urinary protein was ( 9.79 ± 3.42 ) g/24 h before treatment and (38.10 ± 5.16) g/L,(0.78 ± 0.11 ) g/L,(0.16 ± 0.13)g/L,4.01 ± 1.24,( 1.14 ± 0.59) g/24 h after treatment,and there were significant differences between before treatment and after treatment (P ＜ 0.01 ).During the therapy,side effects were reported in 22 patients.However,these side effects had no impact on the therapy.After further treatment,these side effects gradually decreased and eventually disappeared.Conclusions Cyclophosphamide pulse therapy combined with LEF is effective in treating RLN.Patients' tolerance to the therapy is generally very good.

Animals ; Humans ; Ischemic Preconditioning, Myocardial ; MicroRNAs ; Myocardial Ischemia ; genetics ; prevention & control