No abstract available.
beta-Thalassemia* ; Thalassemia*

No abstract available.
beta-Thalassemia*

No abstract available.
beta-Thalassemia*

Despite having the highest prevalence of thalassemia in Malaysia, studies exploring factors that contribute to high thalassemia births in Sabah is still lacking. This study aimed to explore the reasons that may contribute to mothers in Sabah having multiple children with β-thalassemia major (β-TM). In-depth, semi-structured interview was conducted on 18 mothers with more than one β-TM child in two thalassemia treatment centres in Sabah. Thematic analysis was performed by two researchers and comparison of codes and sub-themes were made to verify the themes emerged. The thematic analysis revealed five core themes for reasons of mothers having multiple children with β-TM: 1) intention to have more children and acceptance towards child’s condition; 2) lack of understanding about thalassemia inheritance pattern; 3) barriers in prenatal screening; 4) barriers in abortion; and 5) ineffective family planning. Early identification of mothers with intention to have more children should be considered for active counselling. Providing continuous informational and financial support may increase uptake in prenatal screening, and involvement of local religious leaders to disseminate information regarding thalassemia prevention measures may improve effort to reduce thalassemia births in Sabah.
beta-Thalassemia

No abstract available.
beta-Thalassemia ; Hematologic Neoplasms

The rate of general population carries the gene of Beta-thalassemia in some countries was high such as North of Italia (20%), Sardinia (11-34%), and Cyprus (5-15%). The frequency of gene carrier of Beta-thalassemia was quite common such as Laos (9.6%), Thailand (6%), and South of China and Cambodia. This rate in Kinh Nation of Vietnam was 1.5-2% higher than other minorities. It was estimated that there were 1.17-1.56 millions of Vietnamese who carry the gene of Beta-thalassemia.
beta-Thalassemia ; epidemiology

50 samples of blood from patients diagnosed as betathalassemia in the center for blood transfussion and cryopreservation at minus 20oC and studied in the Mahidol University, where, DNA extracted by phenol and chloroform and the mutation analysed by technique of PCR and RDBH. The investigation of mutation that caused thalassemia help to establish the Center for the prenatal diagnosis, prevention and control of thalassemia in Vietnam.
beta-Thalassemia ; diagnosis ; mutation

Genotype ; Humans ; beta-Thalassemia

Background: \u03b2-thalassemia is a hereditary disease caused by disorder in \u03b2-globin chain synthesis process. In this research, multiplex-PCR was used in combination with blood chemistry assays and clinical symptoms to detect \u03b2-globin mutations. Objectives: (1) to identify the \u03b2-thalassemia mutation spectrum in the North of Vietnam; (2) to determine the relation between biochemistry values and types of mutations. Subject and methods: Blood samples collected from 60 pediatric patients were used in screening assays (hemoglobin counting, red blood cell counting, hematocrit\ufffd? and multiplex-PCR to detect 6 point mutations with high prevalence in the region. Results: \r\n', u'(1) Of 60 blood samples collected from pediatric patients, 30 (50%) had mutation in codon 17 (A\u2192T), 6 (10%) had a frameshift mutation in codons 41/42 and 4 (6%) had both types of these mutations; (2) The average onset time in patients with FS 41/42 mutation was earlier than that of patients with codon 17 (A\u2192T) mutation, whereas transfusion interval did not differ significantly among these patients; (3) Mean corpuscular volume (MCV) was lower in patients with homozygous mutations (\u03b2o) (average 64.8) than in those with heterozygous mutations (\u03b2+) (average 72.7). Conclusions: (1) multiplex-PCR is an effective technique in identifying the mutation spectrum of \u03b2-globin gene in the North of Vietnam; (2) Biochemistry assays should be associated with molecular techniques in diagnose of \u03b2-thalassemia\r\n', u'\r\n', u'\r\n', u'
beta-Thalassemia ; Thalassemia ; Genetic Diseases ; Inborn ; Mutation

Hemoglobins, Abnormal ; Humans ; alpha-Thalassemia ; complications ; beta-Thalassemia ; complications