2.Exercise induced delayed bronchoconstriction in children with asthma.
Eun Jin CHOI ; Hyo Kung SHIN ; Un Ki YOON ; Ji Sub OH
Journal of the Korean Pediatric Society 1992;35(6):769-775
No abstract available.
Asthma*
;
Asthma, Exercise-Induced
;
Bronchoconstriction*
;
Child*
;
Humans
3.Isocyanate-induced occupational asthma: immunologic and challenge studies.
Hae Sim PARK ; Seong Jin KIM ; Nam Soo RHU ; Dong Ill CHO ; Jae Won KIM ; Nan Ho KYUNG
Tuberculosis and Respiratory Diseases 1992;39(6):490-501
No abstract available.
Asthma, Occupational*
4.Assessment of respiratory impairment/disability in occupational asthma.
Tuberculosis and Respiratory Diseases 1992;39(6):484-489
No abstract available.
Asthma, Occupational*
5.Occupational Asthma as a Differential Diagnosis of Adult-Onset Asthma – A Case Report
Malaysian Journal of Medicine and Health Sciences 2019;15(2):145-147
Bronchial asthma causes great morbidity and mortality worldwide. Certain occupations especially those exposed to known triggers of asthma such as animal fur, dusts or solvents may trigger asthma attacks in a previously undiagnosed individual or worsen its’ control in a known asthmatic. This is especially true for adult-onset asthma. This may in turn the health of the affected workers and affect their productivity. Affected workers may be given job reassignment and eligible for medical compensation from Social Security Organisation (SOSCO). This case report will look at how two individuals in very distinct occupation were diagnosed with suspected occupational asthma
Occupational asthma
6.Incidence of Exercise-Induced Asthma in One Elementary School Children.
Eung Won PARK ; Dong Uk KIM ; Won Ho CHOI ; Kwang Woo KIM
Journal of the Korean Pediatric Society 1990;33(11):1557-1561
No abstract available.
Asthma, Exercise-Induced*
;
Child*
;
Humans
;
Incidence*
7.Three cases of occupational asthma induced by urethane paint.
Byung Soon CHOI ; Hae Kwan CHEONG
Korean Journal of Occupational and Environmental Medicine 1992;4(2):212-220
No abstract available.
Asthma, Occupational*
;
Paint*
;
Urethane*
8.Role of Matrix Metalloproteinase in the Pathogenesis of Bronchial Asthma.
Tuberculosis and Respiratory Diseases 2002;53(2):101-112
BACKGROUND: Toluene diisocyanate(TDI) is a leading cause of occupational asthma. However, the pathogenesis of TDI-induced asthma is largely unknown because there is no suitable animal model. METHODS: We developed a murine model of TDI-induced asthma by performing two sensitization with 3% TDI and one challenge with 1% TDI using ultrasonic nebulization. RESULTS: Similar to occupational asthma in humans, murine TDI-induced asthma includes findings 1) increased inflammatory cells, including neutrophils and eosinophils, 2) histologic changes, including infiltration of inflammatory cells around bronchioles, thickened airway epithelium, contraction of bronchioles, and accumulation of mucus and debris in the bronchioles, 3) increased MMP-9 activity in inflammatory cells in the airway lumen, 4) airway hyperresponsiveness. Administration of an MMP inhibitor, MMPI-I, remarkably reduced all these pathophysiological findings. CONCLUSION: Therefore, we conclude that TDI-induced occupational asthma is associated with the induction of MMP-9 in inflammatory cells, and the inhibition of MMP-9 may be a good therapeutic strategy.
Humans
;
Animals
;
Asthma, Occupational
10.Clinical effect of montelukast in exercise-induced asthma.
Ja Hyung KIM ; Uoo Kyung MIN ; Soo Ok CHOI ; Seong Gene LEE ; Soo Jong HONG
Journal of Asthma, Allergy and Clinical Immunology 2002;22(4):720-727
BACKGROUND: Patients with bronchial asthma frequently have exercise-induced bronchocon striction. Exercise-induced bronchoconstriction limits the activities important for physical and social development in children. Leukotriene receptor antagonist has been shown to protect against exercise-induced bronchoconstriction. The purpose of this study is to determine the effect of montelukast in protecting or controlling exercise-induced asthma. METHOD: 22 patients were enrolled and received montelukast(5 mg/day) for 2 months. Exercise challenges were performed before and after treatment and medication was not given for at least 48 hours before follow-up test. The form of exercise was free running for 8 minutes. The respiratory symptom scores, maximum percent fall in FEV1 from pre-exercise baseline and time to recovery of FEV1 to within 10% of pre-exercise baseline were evaluated. RESULTS: The respiratory symptoms score was siginificantly improved after 2 months of therapy(p<0.05). The maximum percent fall in FEV1 after exercise and the time from maximum percent fall in FEV1 to return to within 10 precent of pre-exercise FEV1 were also siginificantly improved after 2 months of therapy(p<0.05). In 3 patients with exercise-induced asthma, the maximum percent fall in FEV1 was decreased after 2 months of therapy, but was increased after follow-up 2 months without therapy. CONCLUSION: Montelukast, a leukotriene-receptor antagonist, is effective for protection and control of exercise-induced asthma in children.
Asthma
;
Asthma, Exercise-Induced*
;
Bronchoconstriction
;
Child
;
Follow-Up Studies
;
Humans
;
Receptors, Leukotriene
;
Running
;
Social Change