Aged ; Angiofibroma ; metabolism ; pathology ; Desmin ; metabolism ; Diagnosis, Differential ; Female ; Humans ; Inflammation ; Leiomyosarcoma ; pathology ; Neoplasms, Muscle Tissue ; metabolism ; pathology ; Vimentin ; metabolism ; Vulvar Neoplasms ; metabolism ; pathology

When people are walking, they will produce gait signals and different people will produce different gait signals. The research of the gait signal complexity is really of great significance for medicine. By calculating people's gait signal complexity, we can assess a person's health status and thus timely detect and diagnose diseases. In this study, the Jensen-Shannon divergence (JSD), the method of complexity analysis, was used to calculate the complexity of gait signal in the healthy elderly, healthy young people and patients with Parkinson's disease. Then we detected the experimental data by variance detection. The results showed that the difference among the complexity of the three gait signals was great. Through this research, we have got gait signal complexity range of patients with Parkinson's disease, the healthy elderly and healthy young people, respectively, which would provide an important basis for clinical diagnosis.
Aged ; Gait ; Healthy Volunteers ; Humans ; Parkinson Disease ; physiopathology ; Reference Values ; Signal Processing, Computer-Assisted ; Walking

Microbial genome reduction and modification are important strategies for constructing cellular chassis used for synthetic biology. This article summarized the essential genes and the methods to identify them in microorganisms, compared various strategies for microbial genome reduction, and analyzed the characteristics of some microorganisms with the minimized genome. This review shows the important role of genome reduction in constructing cellular chassis.
Genes, Essential ; genetics ; Genetic Engineering ; Genome, Microbial ; genetics ; Synthetic Biology ; methods

The quality of sleep has a great relationship with health and working efficiency. The result of sleep stage classification is an important indicator to measure the quality of sleep, and it is also an important way to diagnose and treat sleep disorders. In this paper, the method of detrended cross-correlation analysis (DCCA) was used to analyze sleep stage classification, sleep electroencephalograph signals, which were extracted from the MIT-BIH Polysomno graphic Database randomly. The results showed that the average DCCA exponent of the awake period is smaller than that of the first stage of non-rapid eye movement (NREM) sleeps. It is well concluded that the method of studying the sleep electroencephalograph with this method is of great significance to improve the quality of sleep, to diagnose and to treat sleep disorders.
Electroencephalography ; Humans ; Signal Processing, Computer-Assisted ; Sleep Stages

OBJECTVEThis study evaluates the expression of interleukin-18 (IL-18) and hypoxia-inducible factor (HIF)-lα in rat periodontitis model exposed to normoxia and chronic intermittent hypoxia (CIH) environments. The possible correlation between periodontitis and obstructive sleep apnea-hypopnea syndrome (OSAHS) was also investigated. Methods: Thirty-two Sprague-Dawley (SD) rats were randomly assigned into four groups: normoxia control, normoxia periodontitis, hypoxia control, and hypoxia periodontitis groups. The periodontitis models were established by ligating the bilateral maxillary second molars and employing high-carbohydrate diets. Rats in hypoxia control and hypoxia periodontitis groups were exposed to CIH treatment mimicking a moderately severe OSAHS condition. All animals were sacrificed after eight weeks, and the clinical periodontal indexes were detected. The levels of IL-18 and HIF-1α in serum and gingival tissues were determined using enzyme-linked immunosorbent assay (ELISA). The correlation between attachment loss (AL) and the levels of IL-18 and HIF-lα in hypoxia periodontitis group was evaluated.

RESULTSThe levels of IL-18 and HIF-lα in hypoxia periodontitis group were significantly higher than that in normoxia periodontitis and hypoxia control groups (P<0.05). Furthermore, the levels of IL-18 and HIF-lα in serum (r-0.792, r=0.753, P<0.05) and gingival tissues (r-0.817, r=0.779, P<0.05) were positively correlated with AL.

CONCLUSIONCIH could aggravate the destruction of periodontal tissues, which is correlated with IL-18 and HIF-lα levels.

Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Gingiva ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Interleukin-18 ; Periodontal Index ; Periodontitis ; Rats ; Rats, Sprague-Dawley ; Serum ; Sleep Apnea, Obstructive

Objective To discuss the detail design of medical linear accelerator room to optimize the layout of radiation shield.Methods According to the optimization principle for medical exposure protection and national radiation protection related documents,the influence of detail design on room quality was analyzed.Optimization design was executed from theaspects of spatial layout,protection,shielding wall,decorating materials,labyrinth,control cabin,protective door,occupancy factor,purification ventilation,tennperature humidity control and etc.Results The design and layout of the roomwere optimized to eliminate hidden risksand reduce the design flaws to prevent adverse consequences due to design errors.Conclusion Detail design contributes to stable operation,enhanced quality and efficiency of medical linear accelerator room.

Objective To investigate the fluconazole capsule combined with Zhibaidihuangwan on Trichomonas vaginitis patients on serum IL-10,TNF-α and clinical effect.Methods 78 cases of trichomonas vaginitis patients were collected in our hospital,randomly divided into two groups: experimental group and control group,with 39 cases in each.After admission,the patients in the control group received fluconazole 0.2g,onetimes aday; patients in the experimental group on the basis of the control group given Zhibai dihuangwan eight pills/time,threetimes a day,continuous treatment for fourweeks.Observation and comparison of two groups of patients before and after treatment of interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),the patient's vaginal health score and the level of clinical efficacy.Results compared with before treatment,IL-10,TNF-α levels were decreased after treatment of the two groups,the difference is statistically significant(P<0.05); Compared with the control group,IL-10,TNF-α is low of patients in the experimental group,the difference has statistical significance(P< 0.05);Compared with before treatment,the patients in the two groups of vagina health score were significantly increased after treatment,the difference is statistically significant(P<0.05); Compared with the control group,the vagina health score is higher in experimental group patients,the difference is statistically significant(P< 0.05); Compared with the control group,the the total efficiency is higher of patients in the experimental group,the difference is statistically significant(P<0.05).Conclusion fluconazole capsule combined with Zhibaidihuangwan can reduce trichomonad vaginitis patients serum IL-10,TNF-α levels,improve clinical symptoms,clinical curative effect is better.

Objective To construct a set of systematic and standardized intermediate and senior assessment table for nursing staff by the guidance of the competency theory. Methods Delphi technique was used to complete this study based on the nurse competency requirements. Results The coefficient of variationin the two rounds of experts consultation were 0.1376-0.1947;the authority coefficient was 0.93; the assessment of project and contents were 9.56%-21.79% and 7.14%-19.27%. Conclusions The intermediate and senior assessment table for nursing staff based on the competency is scientific and practical which can be applied to nursing human resource management.

In recent years, neuro-electrophysiological techniques, as objective evaluation methods, have been gradually used in func-tional evaluation, guiding clinical rehabilitation programs and judging prognosis after stroke. They were proved to judge the integrity of cen-tral nervous system and conduction function and evaluate neuromuscular function. Nerve conduction, needle electromyography, H reflex, F wave, sympathetic skin response, motor-evoked potentials, somatosensory-evoked potentials, brain stem auditory-evoked potentials and sur-face electromyography were reviewed in this article.

Objective To investigate the status of work-family balance,and explore the relationship between work-family balance and well-being of female prison police.Methods 185 female prison police from one of prison of Sichuan province were assessed using the questionnaires of work-family balance ques tionnaire and well-being scale,and the data were analyzed using t test,one-way ANOVA,pearson correlation analysis and logical multiple linear regression analysis.Results The total score of work-family balance was (10.22± 1.32).The dimension score of work-family balance from high to low were:resource sharing(3.44± 0.60),family balance (3.38±0.53) and work balance (3.12±0.60).There was no remarkable difference on work-family balance between stage of age and family monthly income;but work-family balance declined with the increases of marriageable age and working age (F=13.01,8.25,both P＜ 0.01).Work balance,family balance resource sharing,work-family balance had significant positive correlation with well-being and it's dimensions(r=0.15 ～ 0.60,P＜0.05).Regression analysis showed that age,marriageable age had a negative predic tive effect on job satisfaction and emotion satisfaction(β=-0.20,-0.24,both P＜0.01),and work family balance and it's dimensions had a positive predictive effect on well-being(3=0.282～0.679,P＜0.01).Conclusion Work-family balance has a significant predictive effect on well-being of female prison police.