Postprandial hyperglycemia is one of the characteristics of glucose profiles in Chinese T2DM patients. High-ratio premix insulin analogues with advantages of excellent pharmacokinetic characteristics and flexible and convenient administration provide a comprehensive solution for Chinese T2DM patients to effectively control postprandial glucose and reduce blood glucose fluctuation. This paper is a literature review on its clinical evidence and experience.

Chinese genuine regional herbs are a combination of nature resource and traditional knowledge. Although we can make it to be an intellectual property product through applying geographical indication or certification mark, the value realization of Chinese genuine regional herbs should be supported by the merchant capital. Meanwhile, the merchant capital also disturbs the reasonable market price of Chinese genuine regional herbs. We should combine the merchant capital with Chinese genuine regional herbs, apply permission for sale and set up a new professional cooperation mode to maintain the market credibility and reasonable price of Chinese genuine regional herbs.

Atopic dermatitis is a common chronic recurrent atopic constitution-associated inflammatory skin disease mainly characterized by eczematous lesions and itching. Its etiology and pathogenesis are still not very clear, and there are many controversies about its origin, definition, clinical phenotypes and diagnostic criteria. This review analyzes and discusses these controversies in order to provide a meaningful reference for the diagnosis and treatment of atopic dermatitis.

No absteact available.
Resuscitation*

Adult ; Burns ; etiology ; Humans ; Male ; Occupational Exposure ; Phosphorus ; adverse effects ; Young Adult

Hereditary Autoinflammatory Diseases ; Humans

No abstract available.
Animals ; Embryo Implantation* ; Embryonic Structures* ; Female ; Mice* ; Pregnancy

No abstract available.
Agglutination* ; Alisma* ; Animals ; Erythrocytes* ; Mice* ; Plantago*

Objective To evaluate the clinical value of laparoscopic and open radical gastrectomy for gastric cancer in advanced stage(D2).Methods A retrospective analysis was conducted in 100 patients with advanced gastric cancer who underwent surgical treatment.The patients were randomly divided into laparotomy group (n=44) and laparoscopic group (n=56).The laparotomy group was treated with D2 radical operation for advanced gastric cancer by the conventional laparotomy, while the laparoscopic group underwent laparoscopic radical resection of advanced gastric cancer with D2.The surgery related indicators, as well as intraoperative and postoperative complications etc.were compared between the two groups.All patients were followed up for 24 months.The recurrence, metastasis and mortality of the patients in the two groups were compared.Results The operation time and the amount of bleeding of the laparoscopic group were less than those of the laparotomy group (P=0.020, 0.001).The postoperative intestinal function recovery and hospitalization time of the laparoscopic group were shorter than those of the laparotomy group (P=0.020,0.001).There was no significant difference between the two groups in the number of lymph node dissection (P=0.650).Various complications occurred in the two groups, such as bleeding, spleen injury, vascular injury of colon injury and pancreatic injury, but the difference between the two groups was not statistically significant (P=1.000,0.570,1.000,1.000).There was no significant differences between the two groups in pancreatic fistula, anastomotic leakage, remnant stomach weakness and anastomotic bleeding (P=0.020,0.005,1.000,1.000,0.570).After 24 months of follow-up, there was no significant difference in recurrence, metastasis and mortality between the two groups (P=0.450,0.290,0.530).Conclusion Endoscopic surgery for D2 resection in the treatment of advanced gastric cancer has advantages, such as less trauma, rapid recovery and so on, can reduce the occurrence of postoperative complications.

Objective To investigate the correlation of smokers in wnt/β-catenin signaling pathway activation as well as their correlation with lung squamous cell carcinoma incidence.Methods In the Department of Respiratory Medicine of the People's Hospital of Wuhan University,30 cases lung squamous cell carcinoma patients with a history of smoking,30 cases lung squamous cell carcinoma patients with no history of smoking,30 cases bronchiectasis patients with a history of smoking,30 cases bronchiectasis patients with no history of smoking were chose respectively as A group,B group,C group and D group.After the patients were treated by surgery,the removal of diseased tissue used immunohistochemical staining for CD68 + testing,TNF-α,wnt-2,β-catenin and the expression of TCF-4 were measured by using Western blot hybridization method,then wnt-2,β-catenin,TCF-4 transcription of mRNA concentrations were detected by using RT-PCR method.Results Immunohistochemical studies showed that cells in TNF-α,CD68 + expression of A group,B group,C group and D group were respectively 0.895±0.036 and 0.931±0.237,0.125±0.018 and 0.631±0.064,0.083±0.042 and 0.311±0.062,0.053±0.004 and 0.196±0.020,the differences were statistically significant(P＜0.05).Westblot test Results showed that wnt-2,β-catenin,TCF-4 expression level showed a gradually decreasing trend,the difference was statistically significant(P＜0.05),testing of RT-PCR showed that wnt-2,β-catenin,TCF-4 translation level showed a gradually decreasing trend,the difference was statistically significant(P＜0.05).Conclusion Smoking for body wnt/β-catenin pathway has a cell activation,after cigarette activate wnt/β-catenin signaling pathway in the incidence of lung squamous cell carcinoma of the body will greatly enhance the smoking crowd wnt/β-catenin signaling transduction circumstances.The detection of wnt/beta-catenin signal transduction in smokers can be used to indicate the occurrence of lung squamous cell carcinoma.