Objective To investigate the clinical value of combined detection of serum human epididymis protein 4(HE4),carbo-hydrate antigen 125(CA125)and tumor marker(CEA)in the diagnosis and staging of ovarian cancer.Methods 90 cases of ovarian cancer(ovarian cancer group),120 cases of benign ovarian disease(ovarian benign group)and 60 cases of healthy women(healthy control group)were selected from March 2014 to 2016 March in our hospital.The levels of HE4 and CA125 and CEA were detected by immunochemiluminescence assays,the results of the three groups were compared and analyzed.Results The positive rate of 3 indicators in the ovarian cancer group was significantly higher than that of the ovarian benign group and the healthy control group (P <0.05).The positive rates of combined detection of Ⅰ-Ⅳ in ovarian cancer were 81.2%,92.1%,97.4% and 100.0%,and CEA,CA125 and HE4 joint inspection in different stages of ovarian cancer positive rate is significantly higher than that of single in-dex positive detection rate.Conclusion The clinical value of HE4,CA125,CEA combined test for the diagnosis and staging of ovar-ian cancer is significant,it is worth to be further promoted.

Objective To discuss the occurrence of adverse drug reactions (ADR) induced byDanhong Injection; To provide references for rational clinical medication.Methods Literature related to ADR induced byDanhong Injection was retrieved from CNKI, Wanfang database and CBM database during Jan. 2004 to Dec. 2015. Literature was selected based on inclusion and exclusion criteria. Data were collected and analyzed by metrology.Results 116 cases of ADR induced byDanhong Injection were included. The analysis showed that there was no significant correlation between ADR and gender. Most of ADR cases occurred over the age of 50 and within 30 min after medication. Multiple organs and systems were involved in ADR. Damages in skin tissue, the whole body, and respiratory system were common. Relevant clinical symptoms were mainly itching, skin rash, fever, shiver and shortness of breath. However, anaphylactic shock was needed to be aware of.Conclusion The incidence of ADR induced byDanhong Injection requires great attention in order to standardize medication and improve safety.

Objective To compare methimazole and propylthiouracil affecting liver function by treating hyperthyroidism.Methods Total 80 patients with hyperthyroidism were randomly divided into two groups.Group A (41 cases) was given methimazole,group B (39 cases) was given propylthiouracil.The effect of methimazole and propylthiouracil affecting liver function by treating hyperthyroidism was evaluated by the indexes of thyroid function,liver function,liver damage,and adverse reaction during treatment.Results Before treatment,there were no statistical significance on FT3 and FT4 between two groups.After treatment,the FT3and FT4 were decreased and TSH was increased in two groups (P ＜ 0.05).But there were no statistical significance between two groups.Before treatment,there was no statistical significance on ALT,AST,and GGT between two groups.After treatment,the ALT,AST,and GGT increased in group B and higher than that of group A (P ＜ 0.05).The ALT,AST,and GGT had no change before and after treatment in the group A.During treatment,there were five cases of liver injury in group A and 14 cases in group B.The liver injury rate of group B was higher than that of group A (P ＜ 0.05) and injury time of group B was later than that of group A.During treatment,there was no statistical significance on adverse reaction rate between two groups.Conclusion The efficacy of methimazole was equal to propylthiouracil in treating hyperthyroidism.Compared with propylthiouracil,the methimazole had less injury on liver but induce the liver injury in earlier.It is suggested that the patients should check the liver function regularly during treatment.

Hepatitis B recurrence is one of the most frequent complications that will probably result the treat failure of liver transplantation. As many as 80% of patients with HBV are reinfected by this virus after liver transplantation. This has been the most deadly case that threatens patient survival amongst all problems emerging from liver transplantation executed for Hepatitis B ralated hepatocirrhosis. In recent years a great deal of prophylaxis practices have been adopted, which has greatly reduced the possibility of Hepatitis B recurrence. The present paper reviews the causes and treatment of Hepatitis B recurrence after liver transplantation.

Objective To investigate the related factors of encephalopathy following orthotopic liver transplantation (OLT).Methods The clinical data of 128 patients who underwent liver transplantation consecutively between October 2001 and October 2003 were analyzed retrospectively by SPSS 10.0 . All clinical factors were analyzed by Crosstabs or independent-samples t test. A mutivariative analysis of these significant factors was done by using the Binary Logistic Regression.Results Encephalopathy occurred in 21 cases within the first week after operation, including 19 cases of Child-pugh C and 2 cases of Child-pugh B. There was a higher occurrence in the patients with chronic severe hepatitis or undergoing re-transplantation ( P 0.05 ). In the encephalopathy group the incidence of renal failure after transplantation and infection pre- or postoperation was higher than in control group ( P

The ultrastructure of hepatic fat-storing cells in rat embryos was investigatedwith transmission electron microscope.It is considered that the rat fat-storingcells originate from mesenchymal cells.As the embryo develops,the fat-storing cell decreases in size gradully,this isespecially obvious at the time of birth.This may be related with the function of thistype of cell.In the hepatic fat-storing cell in embryo of 10 to 12 days,the roughendoplasmic reticulum has developed,the cell is rich in free ribosomes,and collagenfibrils may be observed in Disse's spaces.This indicates that the fat-storing cellshave possessed the function of synthesizing collagen.In embryo of 13 to 15 days,fat droplets appear in a few fat-storing cells and smooth endoplasmic reticulum, glycogen granules and pinocytosis may be seen at this time.It is suggested that thefunction of the uptake and storage of vitamin A may appear at that time too.There are desmosomes between the fat-storing cell and the hepatocyte.On the 16to 18 days,desmosomes are also present between the fat-storing cell and endothelialcell.This indicates that fat-storing cells are not free cells,but are bound to hepa-tocytes and endothelial cells via cellular junctions,At that time,microfilaments andmicrotubules are found in fat-storing cells,they are the skeleton of the cells andthey may be related to the regulation of the size of the sinusoids.In thedevelopment of embryo,the number of fat-storing cells and fat droplets have notincreased markedly,therefore,it is thought that they are increased after birth.

Objective:Research on the feasibility and the availability of problem-based learning(PBL) for electrocardiogram(ECG).Method:The experiment group received PBL while the control group took completely traditional teaching method.The evaluation approaches included examination,questionnaire.Results:It is significant difference in the theoretical record and case analysis(t=2.76,P

[Objective]To introduce the traditional application and modern research of Radix Gentianae and to provide reference to developing and researching Radix Gentianae.[Methods]We analyzed the number of representative literature home and abroad and summed them up.[Result]Studies about traditional Chinese medicinal application,traditional Chinese medicinal resources,chemical composition,pharmacodynamics,pharmaceutical preparation and clinic of Radix Gentianae have been generalized.[Conclusion]At present traditional Chinese medicinal resources,chemical composition,pharmacodynamics and clinic of Radix Gentianae have been studied a lot,but studies about quality evaluation,the reason of droping out the market and the dynamic of ecosystem of G.manshurica var.yanchowensis have been relatively carried out a little.And all of them deserve research.

Objective To study the effect of thiazolidinediones on vascular endothelial function in patients with type 2 diabetes mellitus.Methods 50 patients with type 2 diabetes were randomly selected as the research objects,the representative drug pioglitazone application situation for 50 patients were measured before and after the treatment,fasting blood glucose,postprandial 2h blood glucose,total cholesterol,high density lipoprotein cholesterol, low density lipoprotein,total cholesterol,triglyceride,fasting insulin,glycosylated protein and inflammatory factors in red vascular cell adhesion factor were detected.Results the patients after treatment of endothelium dependent vaso-dilatation function improved,compared with those before treatment (P <0.05),fasting blood glucose,patients after the treatment of 2h after meal blood glucose.Conclusion The two thiazolidinediones can effectively improve type 2 diabetes vascular endothelial function,and have a positive effect on the prevention of patients with cardiovascular dis-ease.