OBJECTIVE: To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton. METHODS: Platelets were isolated from zyxin-knockout (Zyx RESULTS: After zyxin gene was knockout, the expressions of cytoskeleton proteins β-actin, α-actinin, filamin A, and myosin Ⅱ A in resting and Jas-induced platelets were significantly increased. In the platelet spreading on fibrinogen surface, F-actin was increased in Zyx CONCLUSION Zyxin significantly regulates the distribution of platelet cytoskeleton, which plays an important role in maintaining platelet cytoskeleton homeostasis.
Actinin ; Actins ; Animals ; Blood Platelets ; Cytoskeleton ; Mice ; Zyxin

Antisperm antibodies can lead to immunological infertility. Further research on the target antigens of antisperm antibodies may help to discover the causal relationship of antisperm antibodies to infertility. This paper summarizes the structure and function of the six target antigens of antisperm antibodies found recently, so as to discover the causal relationship of the antibodies to infertility and provide a basis for screening a vaccine for immunological contraception.
Amyloid beta-Protein Precursor ; chemistry ; immunology ; Antibodies ; immunology ; Antigen-Antibody Reactions ; Cytoskeletal Proteins ; Glycoproteins ; chemistry ; immunology ; Humans ; Infertility, Male ; etiology ; Male ; Nerve Tissue Proteins ; chemistry ; immunology ; Nuclear Pore Complex Proteins ; Nuclear Proteins ; Spermatozoa ; immunology ; Zyxin