Objective To establish a scientific and rational nurse scheduling model for saving nursing human resources and schedule time for head nurses. Methods The nurses and the patients were divided into groups respectively. According to the principle of convention and common multiple, the mathematical logic algorithm was used to calculate working hours, rest and backup scheduling. Results ST basic scheduling model was established and the extension model 1, 2, and merge models 1, 2 was added on the basic of ST scheduling. Conclusions Based on the basic model, free combination and extension model, appropriate scheduling model was selected according to the number of patients and disease condition. It′s convenient which saves the scheduling time of the head nurses. At the same time, it standardizes the backup scheduling, fixes the backup nurses, and saves the nursing resources.