Objective To analyze the clinical characteristics,diagnosis,treatment and prognostic factors of primary hepatic neuroendocrine tumor (PHNET).Methods To analyze the clinical data of 21 patients with PHNET who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2019.There were 11 males and 10 females,with ages which ranged from 36 to 75 years.Log-rank test was used for single-factor analysis of the relationship between clinical and pathological indicators and prognosis.Cox proportional risk model was used for multi-factor analysis.Results Among the 21 PHNET patients,10 presented with central and upper abdominal pain,3 abdominal pain accompanied by nausea and vomiting,5 abdominal distension,and 3 were asymptomatic.Carbohydrate antigen (CA) 19-9 was elevated in 6 patients and CA125 in 7 patients.Abdominal enhanced CT showed solid liver space occupying lesions.Four patients had solitary and 17 had multiple lesions.The mean diameter was 58 mm.Fourteen patients had lymph node metastasis.Five patients underwent radical hepatectomy,2 transcatheter hepatic arterial chemoembolization + chemotherapy,12 chemotherapy,and 2 supportive treatment.Factors which were associated with prognosis of PHNET patients were surgery,tumor grading,cytokeratin positivity and lymph node metastasis.Multivariate Cox regression analysis showed that inoperability (HR =8.99,95％ CI:1.13-71.80) was an independent risk factor of prognosis of PHNET patients.The prognosis in patients who underwent surgical resection was better.Conclusion Patients with PHNET had no specific clinical manifestations.Surgical resection gave the best results in treatment.As surgical resection affected prognosis,it should be carried out if technically feasible.

Objective To investigate the effects of oxycodone hydrochloride combined with propofol on hemodynamics and related indicators in painless fiberoptic bronchoscopy.Methods Ninety patients receiving fiberoptic bronchoscopic examination from January 2016 to May 2017 were selected and divided into the sufentanil+propofol group(group A) and oxycodone hydrochloride+propofol group(group B) according to the random number table method 45 cases in each group.The hemodynamic indicators,intraoperative propofol dosage and incidence rate of adverse reactions in both groups were observed.Results The respiratory rate(RR) in the bronchoscope reaching the glottis(T2) in the group A was significantly higher than that in the group B (P＜ 0.05);mean arterial pressure(MAP),heart rate(HR),blood oxygen saturation(SpO2) and RR at the bronchoscope passing trachea carina(T3) and examination completing(T4) in the group A were significantly higher than those in the group B(P＜0.05).RR at 10 min after the examination completing(T5) in the group A was significantly higher than that in the group B,the difference was statistically significant(P＜0.05).The propofol dosage in the group A was significantlyhigher than that in the group B(P＜0.05);the incidence rate of adverse reactions in the group A was 31.11％,which was significantly higher than 6.67％ in the group B,the difference was statistically significant(P＜0.05).Conclusion Oxycodone hydrochloride combined with propofol can more stabilizes the change of hemodynamic parameters during the bronchofibroscopic examination process compared with sufentanil combined with propofol and can reduce the propofol dosage and incidence rate of adverse reactions.