Objective To explore 3D constructive interference insteady state sequence value of related diseases in trigeminal neuralgia.Methods A retrospective analysis of 62 cases of trigeminal neuralgia as the main symptoms of patients with brain magnetic resonance imaging (MRI) routine scan and 3D constructive interference insteady state (3D-CISS) sequence images,of which 12 cases were enhanced scan,comparative analysis of MRI 3D-CISS sequence and conventional sequence of trigeminal nerve.The lesion showed the condition and was compared with the outcome of the operation.Trigeminal neuralgia-related lesions mainly included the trigeminal nerve brain pool around the vascular compression or transition,solid tumors and tumor-like lesions.Results Preoperative MRI 3D-CISS sequence was used to diagnose the vascular compression or metastasis of the trigeminal nerve pool segment in 46 cases.Forty-five patients were found to be responsible blood vessels.The 3D-CISS sequence showed 95.83％ coincidence with surgical exploration.The routine sequence could not show the trigeminal The brain around the brain was forced or pushed.3D-CISS sequence showed eight cases of solid tumors,routine scan showed six cases of solid tumors.Tumor-like lesions were shown in 6 cases of MRI3D-CISS sequences and routine plain scan sequences.The sensitivity of 3D-CISS sequence to trigeminal neuralgia-related disease was 96.77％,and the sensitivity of MRI routine scan to trigeminal neuralgia was only 19.35％.There was significant difference in the sensitivity of 3D-CISS sequence and conventional plain scan sequence to trigeminal neuralgia-related diseases (P ＜ 0.01).Conclusions MRI 3D-CISS sequence has a significant advantage in trigeminal neuralgia-related disease,and patients with trigeminal neuralgia should routinely use 3D-CISS sequences.

Adult ; Age Factors ; Aged ; Cause of Death ; trends ; China ; Female ; Humans ; Infant ; Male ; Middle Aged ; Neoplasms ; mortality

Orthodontically induced tooth root resorption (OIRR) is a serious complication during orthodontic treatment. Stimulating cementum repair is the fundamental approach for the treatment of OIRR. Parathyroid hormone (PTH) might be a potential therapeutic agent for OIRR, but its effects still lack direct evidence, and the underlying mechanisms remain unclear. This study aims to explore the potential involvement of long noncoding RNAs (lncRNAs) in mediating the anabolic effects of intermittent PTH and contributing to cementum repair, as identifying lncRNA-disease associations can provide valuable insights for disease diagnosis and treatment. Here, we showed that intermittent PTH regulates cell proliferation and mineralization in immortalized murine cementoblast OCCM-30 via the regulation of the Wnt pathway. In vivo, daily administration of PTH is sufficient to accelerate root regeneration by locally inhibiting Wnt/β-catenin signaling. Through RNA microarray analysis, lncRNA LITTIP (LGR6 intergenic transcript under intermittent PTH) is identified as a key regulator of cementogenesis under intermittent PTH. Chromatin isolation by RNA purification (ChIRP) and RNA immunoprecipitation (RIP) assays revealed that LITTIP binds to mRNA of leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) and heterogeneous nuclear ribonucleoprotein K (HnRNPK) protein. Further co-transfection experiments confirmed that LITTIP plays a structural role in the formation of the LITTIP/Lgr6/HnRNPK complex. Moreover, LITTIP is able to promote the expression of LGR6 via the RNA-binding protein HnRNPK. Collectively, our results indicate that the intermittent PTH administration accelerates root regeneration via inhibiting Wnt pathway. The lncRNA LITTIP is identified to negatively regulate cementogenesis, which activates Wnt/β-catenin signaling via high expression of LGR6 promoted by HnRNPK.
Mice ; Animals ; Cementogenesis ; Wnt Signaling Pathway ; beta Catenin/metabolism* ; Heterogeneous-Nuclear Ribonucleoprotein K/metabolism* ; RNA, Long Noncoding/genetics* ; Parathyroid Hormone ; Receptors, G-Protein-Coupled/metabolism*